Detalhe da pesquisa
1.
Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35131851
2.
Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
PLoS Pathog
; 14(3): e1006935, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29509814
3.
3D-e-Chem-VM: Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine.
J Chem Inf Model
; 57(2): 115-121, 2017 02 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28125221
4.
Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry.
Angew Chem Int Ed Engl
; 56(12): 3309-3313, 2017 03 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28194834
5.
Involvement of a Hydrophobic Pocket and Helixâ 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor.
Chembiochem
; 16(18): 2668-77, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26449282
6.
Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs).
Mol Pharm
; 12(11): 4048-55, 2015 Nov 02.
Artigo
Inglês
| MEDLINE | ID: mdl-26412035
7.
Discovery of small molecule CD40-TRAF6 inhibitors.
J Chem Inf Model
; 55(2): 294-307, 2015 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-25622654
8.
In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.
Chem Res Toxicol
; 27(5): 873-81, 2014 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-24713091
9.
Influence of azide incorporation on binding affinity by small papain inhibitors.
Bioorg Med Chem
; 22(20): 5593-603, 2014 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24972724
10.
High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 9): 1798-807, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23999303
11.
RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models.
Vaccines (Basel)
; 11(3)2023 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36992257
12.
Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen.
NPJ Vaccines
; 8(1): 176, 2023 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37952003
13.
From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters.
Chemistry
; 18(30): 9246-57, 2012 Jul 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22736391
14.
Pharmacophore fingerprint-based approach to binding site subpocket similarity and its application to bioisostere replacement.
J Chem Inf Model
; 52(8): 2031-43, 2012 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22830492
15.
Stabilizing the closed SARS-CoV-2 spike trimer.
Nat Commun
; 12(1): 244, 2021 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33431842
16.
Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT.
Chembiochem
; 10(4): 716-27, 2009 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-19199329
17.
High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.
Chemistry
; 15(41): 10809-17, 2009 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-19746363
18.
Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.
Front Cell Infect Microbiol
; 9: 364, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31709196
19.
Molecular interaction fingerprint approaches for GPCR drug discovery.
Curr Opin Pharmacol
; 30: 59-68, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27479316
20.
Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity.
Sci Rep
; 5: 14533, 2015 Sep 29.
Artigo
Inglês
| MEDLINE | ID: mdl-26416158