Detalhe da pesquisa
1.
A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study).
Clin Infect Dis
; 73(11): e4539-e4548, 2021 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32785589
2.
Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 65(12): e0089521, 2021 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34516243
3.
Ceftolozane/Tazobactam in Neonates and Young Infants: The Challenges of Collecting Pharmacokinetics and Safety Data in This Vulnerable Patient Population.
Am J Perinatol
; 38(8): 804-809, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31910460
4.
Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin.
Br J Clin Pharmacol
; 86(5): 944-957, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31856304
5.
Ceftolozane-Tazobactam Population Pharmacokinetics and Dose Selection for Further Clinical Evaluation in Pediatric Patients with Complicated Urinary Tract or Complicated Intra-abdominal Infections.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30962340
6.
Population pharmacokinetics of tazobactam/ceftolozane in Japanese patients with complicated urinary tract infection and complicated intra-abdominal infection.
J Infect Chemother
; 25(3): 182-191, 2019 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-30528208
7.
Exploring the Pharmacokinetic/Pharmacodynamic Relationship of Relebactam (MK-7655) in Combination with Imipenem in a Hollow-Fiber Infection Model.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29507068
8.
Intrapulmonary Pharmacokinetics of Relebactam, a Novel ß-Lactamase Inhibitor, Dosed in Combination with Imipenem-Cilastatin in Healthy Subjects.
Antimicrob Agents Chemother
; 62(3)2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29311084
9.
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Relebactam, a ß-Lactamase Inhibitor, in Combination with Imipenem and Cilastatin in Healthy Participants.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29914955
10.
Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection.
Antimicrob Agents Chemother
; 60(10): 6234-43, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27503659
11.
Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid.
Br J Clin Pharmacol
; 81(6): 1113-23, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26852277
12.
Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid.
Pharm Res
; 33(4): 856-67, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26626793
13.
Raltegravir has a low propensity to cause clinical drug interactions through inhibition of major drug transporters: an in vitro evaluation.
Antimicrob Agents Chemother
; 58(3): 1294-301, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24295974
14.
Molnupiravir: Mechanism of action, clinical, and translational science.
Clin Transl Sci
; 17(2): e13732, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38593352
15.
Erratum for Rhee et al., "Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Relebactam, a ß-Lactamase Inhibitor, in Combination with Imipenem and Cilastatin in Healthy Participants".
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30478180
16.
Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans.
Pharm Res
; 35(2): 26, 2018 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29368211
17.
Factors Influencing COVID-19 Risk: Insights From Molnupiravir Exposure-Response Modeling of Clinical Outcomes.
Clin Pharmacol Ther
; 113(6): 1337-1345, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37017631
18.
Imipenem/cilastatin/relebactam efficacy, safety and probability of target attainment in adults with hospital-acquired or ventilator-associated bacterial pneumonia among patients with baseline renal impairment, normal renal function, and augmented renal clearance.
JAC Antimicrob Resist
; 5(2): dlad011, 2023 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-36880088
19.
Population pharmacokinetics of molnupiravir in adults with COVID-19: Lack of clinically important exposure variation across individuals.
CPT Pharmacometrics Syst Pharmacol
; 12(12): 1859-1871, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37798914
20.
Pharmacokinetics and pharmacodynamics of once-daily versus twice-daily raltegravir in treatment-naive HIV-infected patients.
Antimicrob Agents Chemother
; 56(6): 3101-6, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22430964