Detalhe da pesquisa
1.
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.
Nature
; 539(7627): 107-111, 2016 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27595393
2.
Targeting renal cell carcinoma with a HIF-2 antagonist.
Nature
; 539(7627): 112-117, 2016 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27595394
3.
3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.
J Med Chem
; 62(15): 6876-6893, 2019 08 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31282155
4.
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).
J Med Chem
; 61(21): 9691-9721, 2018 11 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30289716
5.
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Cancer Res
; 76(18): 5491-500, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27635045
6.
Multiple active site corrections for docking and virtual screening.
J Med Chem
; 47(1): 80-9, 2004 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-14695822
7.
Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.
ACS Med Chem Lett
; 5(1): 78-83, 2014 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24900776
8.
Spirocyclic ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid ß in a higher species.
J Med Chem
; 56(8): 3379-403, 2013 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-23537249