Effects of Different Periodization Strategies of Combined Aerobic and Strength Training on Heart Rate Variability in Older Women.

ABSTRACT: Rodrigues, JAL, Santos, BC, Medeiros, LH, Gonçalves, TCP, and Júnior, CRB. Effects of different periodization strategies of combined aerobic and strength training on heart rate variability in older women. J Strength Cond Res 35(7): 2033-2039, 2021-The preservation of autonomic function has been proposed to be a key determinant of health and longevity. Periodization in combined training (CT) (strength plus aerobic exercise in the same session) might improve autonomic modulation. However, the specific influences of nonperiodized (NP), flexible nonlinear periodized (FNLP), and nonlinear periodized (NLP) strategies of CT on heart rate variability (HRV) are currently unknown. Therefore, we investigated the effects of NP, FNLP, and NLP strategies of CT on HRV in physically active women. In total, 54 physically active older women (61.6 ± 6.3 years) previously engaged in a regular exercise training were randomly allocated into 3 groups: NP, FNLP, and NLP. All the subjects performed 12 weeks of training, 3 times per week, with the sessions divided into aerobic (bicycle or treadmill) and strength exercises. Before and after the exercise training, we examined anthropometric, body composition, and HRV measures (low-frequency [LF], high-frequency [HF], LF/HF, and root mean square successive difference of RR intervals [RMSSD]) during rest, a maximum exercise test, and recovery post-test. Mixed-model measures were used, and statistical significance was set at α = 0.05. The waist circumference reduced only in the NP group (∆ = -2.01%). The RMSSD increased in the NLP (∆ = 76.5%) and LF/HF ratio increased in the FNLP (∆ = 34.51%) during the rest period. There were no differences during the exercise test and recovery after test for LF, HF, LF/HF, or RMSSD. In active women, nonlinear periodization strategies of CT improved one of the cardiovascular health outcomes because HRV is a direct predictor of cardiovascular risk.

Fasted condition in multicomponent training does not affect health parameters in physically active post-menopausal women.

Diet and exercise are the main modifiable factors for cardiovascular disease and may be particularly important in older adults. We investigated the effects of fasting during 12 weeks of multicomponent training in the context of the aging process in physically active post-menopausal women. METHOD: 25 women (60.6 ± 8.9 years) were randomized into two groups: fed (FED, n=12) or fasted (FASTED, n=13) and submitted to multicomponent training. The participants underwent anthropometric, body composition, blood pressure, biochemical blood and physical fitness assessments. RESULTS: There was a reduction in both groups for waist circumference [FED: 100.4±6.8 and 99.1±7.1 cm before and after the intervention, respectively; F = 4.214, p = 0.048; FASTED: 93.1±10.2 and 92.2±8.4 cm before and after the intervention, respectively; p = 0.039]. No significant changes were observed for the other outcomes. DISCUSSION: The current research results, the first in the context of aging, agree with previous studies that analyzed chronic effects of fasting, showing that fasted exercise training did not improve anthropometric measurements, body composition, or blood markers compared to the fed condition after long-term exercise training. Together, these findings suggest that fasting during multicomponent training does not affect health parameters in physically active post-menopausal women.

Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia.

The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact this disease. The aim of this study was to verify the relationship between the FTO gene and the hsa-miR-150-5p expression with overweight/obesity, lipid profile, and fast blood glucose. Men and women (18 years older or above), with body mass index ≥ 18.5 kg/m2, were enrolled in the present study and the FTO gene and hsa-miR-150-5p expression, biochemical parameters of blood and anthropometric measurements were analyzed. The results highlight that the FTO gene expression is associated to obesity (p 0.029), LDL-C (p 0.02) and fasting blood glucose (p 0.02), but not with triglycerides (p 0.69), total cholesterol (p 0.21), and HDL-C (p 0.24). The hsa-miR-150-5p is not associated to obesity (p 0.84), triglycerides (p 0.57), total cholesterol (p 0.51), HDL-C (p 0.75), LDL-C (p 0.32), and fasting blood glucose (p 0.42). The FTO gene expression is related to obesity, LDL-C and blood fasting glucose, representing a good molecular marker for obesity.

Important differences between hypertensive middle-aged women and men in cardiovascular autonomic control-a critical appraisal.

BACKGROUND: Normotensive premenopausal women show a vagal predominance of cardiac autonomic modulation, whereas age-matched men show a predominance of sympathetic modulation. However, some women develop systemic arterial hypertension (SAH) even with preserved ovarian function. Our hypothesis is that these women may have cardiovascular autonomic parameters similar to those of hypertensive men, even when subjected to pharmacological treatment. We aimed to investigate cardiovascular autonomic control and baroreflex sensitivity (BRS) in hypertensive premenopausal women and age-matched men. METHODS: One hundred volunteers between 18 and 45 years of age were assigned to two groups (50 participants each): a hypertensive group including patients with a history of SAH for at least 6 months (25 men and 25 women), who were under treatment with monotherapy (losartan, 25-50 mg/kg); and a normotensive group (25 men and 25 women). Anthropometric, hemodynamic, metabolic, and autonomic cardiovascular assessments were performed focusing on BRS, autonomic modulation of heart rate variability (HRV), and blood pressure variability (BPV). RESULTS: On HRV analysis, women showed higher values of high-frequency (HF) oscillations in absolute and normalized units, lower values ​of low-frequency (LF) in normalized units, and lower LF/HF ratio, as compared with men. When the normotensive and hypertensive groups were compared, hypertensive groups showed lower values ​of total variance and of LF and HF bands in absolute units. On BRS, hypertensive groups showed lower values than the normotensive group. CONCLUSION: Regardless of blood pressure control through pharmacological treatment, hypertensive patients continued to have reduced HRV compared to normotensive, and hypertensive men had more autonomic impairment than hypertensive premenopausal women.

Study of heart rate recovery and cardiovascular autonomic modulation in healthy participants after submaximal exercise.

Heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS) provide important information on cardiovascular autonomic control. However, little is known about the reorganization of HRV, BPV, and BRS after aerobic exercise. While there is a positive relationship between heart rate (HR) recovery rate and cardiorespiratory fitness, it is unclear whether there is a relationship between cardiorespiratory fitness and reorganization of cardiovascular autonomic modulation during recovery. Thus, this study aimed to investigate whether cardiorespiratory fitness influences the cardiovascular autonomic modulation recovery, after a cardiopulmonary exercise test. Sixty men were assigned into groups according to their cardiorespiratory fitness: low cardiorespiratory fitness (LCF = VO2: 22-38 mL kg-1 min-1), moderate (MCF = VO2: 38-48 mL kg-1 min-1), and high (HCF = VO2 > 48 mL kg-1 min-1). HRV (linear and non-linear analysis) and BPV (spectral analysis), and BRS (sequence method) were performed before and after a cardiopulmonary exercise test. The groups with higher cardiorespiratory fitness had lower baseline HR values and HR recovery time after the cardiopulmonary exercise test. On comparing rest and recovery periods, the spectral analysis of HRV showed a decrease in low-frequency (LF) oscillations in absolute units and high frequency (HF) in absolute and normalized units. It also showed increases in LF oscillations of blood pressure. Nonlinear analysis showed a reduction in approximate entropy (ApEn) and in Poincare Plot parameters (SD1 and SD2), accompanied by increases in detrended fluctuation analysis (DFA) parameters α1 and α2. However, we did not find differences in cardiovascular autonomic modulation parameters and BRS in relation to cardiorespiratory fitness neither before nor after the cardiopulmonary test. We concluded that cardiorespiratory fitness does not affect cardiovascular autonomic modulations after cardiopulmonary exercise test, unlike HR recovery.