Determination of Fat-Free Mass Density and its Components in Older Hispanic Adults by In Vivo Methods.

The densitometry method estimates body composition based on cadaver reference values, mainly the fat-free mass density value of 1.100 g/cm3. However, several changes in fat-free mass components by aging, ethnicity, and excess adiposity could influence their density and affect body composition estimations. The present study aimed to compare the mean fat-free mass component values in older Hispanic adults to cadaver reference values. This cross-sectional study included a sample of 420 subjects aged ≥60 yr from northern Mexico. Fat-free mass was determined by the four-compartment model using air displacement plethysmography, the deuterium dilution technique, and dual-energy X-ray absorptiometry for body density, aqueous and mineral fractions of body weight, respectively. A 1-sample t test was used to compare the fat-free mass density and aqueous, mineral, and residue fractions of fat-free mass from subjects in the study to the assumed cadaver reference values. The mean fat-free mass density value for the total sample of older Hispanic adults (1.096 ± 0.011 g/cm3) was significantly (p < 0.001) lower than the assumed value of 1.100 g/cm3, except in obese older men. The mean aqueous fraction of fat-free mass (74.8 ± 3.3%) was higher than the assumed value of 73.8%, and the mean residue fraction of fat-free mass value was lower (18.3 ± 3.4%) than the reference value of 19.4%. Indeed, only the mean mineral fraction of fat-free mass value (6.8 ± 0.8%) was similar to the reference value. In the total sample, all characteristic mean fat-free mass values in these older Hispanic adults differed from cadaver reference values, except the mineral fraction of fat-free mass value.

Predicting novel microRNA: a comprehensive comparison of machine learning approaches.

MOTIVATION: The importance of microRNAs (miRNAs) is widely recognized in the community nowadays because these short segments of RNA can play several roles in almost all biological processes. The computational prediction of novel miRNAs involves training a classifier for identifying sequences having the highest chance of being precursors of miRNAs (pre-miRNAs). The big issue with this task is that well-known pre-miRNAs are usually few in comparison with the hundreds of thousands of candidate sequences in a genome, which results in high class imbalance. This imbalance has a strong influence on most standard classifiers, and if not properly addressed in the model and the experiments, not only performance reported can be completely unrealistic but also the classifier will not be able to work properly for pre-miRNA prediction. Besides, another important issue is that for most of the machine learning (ML) approaches already used (supervised methods), it is necessary to have both positive and negative examples. The selection of positive examples is straightforward (well-known pre-miRNAs). However, it is difficult to build a representative set of negative examples because they should be sequences with hairpin structure that do not contain a pre-miRNA. RESULTS: This review provides a comprehensive study and comparative assessment of methods from these two ML approaches for dealing with the prediction of novel pre-miRNAs: supervised and unsupervised training. We present and analyze the ML proposals that have appeared during the past 10 years in literature. They have been compared in several prediction tasks involving two model genomes and increasing imbalance levels. This work provides a review of existing ML approaches for pre-miRNA prediction and fair comparisons of the classifiers with same features and data sets, instead of just a revision of published software tools. The results and the discussion can help the community to select the most adequate bioinformatics approach according to the prediction task at hand. The comparative results obtained suggest that from low to mid-imbalance levels between classes, supervised methods can be the best. However, at very high imbalance levels, closer to real case scenarios, models including unsupervised and deep learning can provide better performance.

Identification of Amino Acids and Polyphenolic Metabolites in Human Plasma by UHPLC-ESI-QTOF-MS/MS, after the Chronic Intake of a Functional Meal in an Elderly Population.

Novel foods especially formulated and targeted for the elderly population should provide sufficient nutrients and bioactive ingredients to counteract the natural age-related deterioration of various organs and tissues. Dietary protein and phenolic compounds achieve this goal; however, older adults have alterations in their gastrointestinal system that may impact their bioavailability and few studies have been aimed at this population. Since phenolic compounds are the subject of multiple biotransformations by host and microbiome enzymes during the digestion process, identification of their bioavailable forms in human plasma or tissues represents a considerable analytical challenge. In this study, UHPLC-ESI-QTOF/MS-MS, chemometrics, and multivariate statistical methods were used to identify the amino acids and phenolic compounds that were increased in the plasma of elderly adults after a 30-day intervention in which they had consumed an especially formulated muffin and beverage containing Brosimum alicastrum Sw. seed flour. A large interindividual variation was observed regarding the amino acids and phenolic metabolites identified in the plasma samples, before and after the intervention. Three phenolic metabolites were significantly increased in the population after the intervention: protocatechuic acid, 5-(methoxy-4'-hydroxyphenyl) valerolactone, and phloretic acid. These metabolites, as well as others that were not significantly increased (although they did increase in several individuals), are probably the product of the microbiota metabolism of the major phenolic compounds present in the B. alicastrum Sw. seed flour and other food ingredients. A significant decrease in 4-ethyl-phenol, a biomarker of stress, was observed in the samples. Results showed that the incorporation of foods rich in phenolic compounds into the regular diet of older adults contributes to the increase in bioactive compounds in plasma, that could substantially benefit their mental, cardiovascular, and digestive health.

Predictive equations for fat mass in older Hispanic adults with excess adiposity using the 4-compartment model as a reference method.

BACKGROUND: Predictive equations are the best option for assessing fat mass in clinical practice due to their low cost and practicality. However, several factors, such as age, excess adiposity, and ethnicity can compromise the accuracy of the equations reported to date in the literature. OBJECTIVE: To develop and validate two predictive equations for estimating fat mass: one based exclusively on anthropometric variables, the other combining anthropometric and bioelectrical impedance variables using the 4C model as the reference method. SUBJECTS/METHODS: This is a cross-sectional study that included 386 Hispanic subjects aged ≥60 with excess adiposity. Fat mass and fat-free mass were measured by the 4C model as predictive variables. Age, sex, and certain anthropometric and bioelectrical impedance data were considered as potential predictor variables. To develop and to validate the equations, the multiple linear regression analysis, and cross-validation protocol were applied. RESULTS: Equation 1 included weight, sex, and BMI as predictor variables, while equation 2 considered sex, weight, height squared/resistance, and resistance as predictor variables. R2 and RMSE values were ≥0.79 and ≤3.45, respectively, in both equations. The differences in estimates of fat mass by equations 1 and 2 were 0.34 kg and -0.25 kg, respectively, compared to the 4C model. This bias was not significant (p < 0.05). CONCLUSIONS: The new predictive equations are reliable for estimating body composition and are interchangeable with the 4C model. Thus, they can be used in epidemiological and clinical studies, as well as in clinical practice, to estimate body composition in older Hispanic adults with excess adiposity.

The Symbiosis Between Lactobacillus acidophilus and Inulin: Metabolic Benefits in an Obese Murine Model.

Obesity is defined as having an excess of adipose tissue and is associated with the development of diabetes, hypertension, and atherosclerosis, which are the main causes of death worldwide. Research shows that probiotics and prebiotics reduce the metabolic alterations caused by high-fat diets. Therefore, this work evaluated the effect of the incorporation of Lactobacillus acidophilus (probiotic) and inulin (prebiotic) in the diet through obesity markers (biochemical, anthropometric, and molecular markers) in an obese murine model. Four treatments were administered: (1) hypocaloric diet (HD), (2) HD + L. acidophilus, (3) HD + inulin, and (4) DH supplemented with L. acidophilus + inulin for 8 weeks. After treatment, glucose, triglycerides, total cholesterol, HDL-C, and LDL-C in plasma were determined. In addition, the total body weight and adipose tissue were taken to calculate the body mass index. Following RNA extraction from adipose tissue, the expression of PPAR gamma, PPAR alpha, and transforming growth factor beta 1 (TGF1ß) was evaluated by semiquantitative PCR. All treatments showed an improvement in biochemical markers compared to the values of the obese model (p < 0.05). Optimal values for blood glucose (133.2 ± 14.3 mg/dL), triglycerides (71 ± 4.6 mg/dL), total cholesterol (48.9 ± 6 mg/dL), HDL-C (40.9 ± 4.8 mg/dL), and LDL-C (8.4 ± 1.7 mg/dL) were obtained in the mixed treatment. Regarding fat mass index (FMI), prebiotic treatment caused the greatest reduction. On the other hand, mixed treatment increased the gene expression of PPARα and TGF1ß in adipose tissue with DH with L. acidophilus and inulin treatment. This work demonstrates that the use of L. acidophilus and inulin as a complementary treatment is a viable alternative for prevention and action as a complementary treatment for obesity given the reduction in biochemical parameters and anthropometric indices; these reductions were greater than those found in the classic treatment of obesity due to the induction of the expression of genes related to lipid metabolism and anti-inflammatory cytokines, which contribute to reducing the high levels of glucose, triglycerides, and cholesterol caused by obesity.

[Effect of prebiotics, probiotics, and symbiotics on molecular markers of inflammation in obesity.] / Efecto de los prebióticos, probióticos y simbióticos sobre marcadores moleculares de inflamación en la obesidad.

OBJECTIVE: Obesity is an inflammatory disease that is widely distributed in the world's population and is related to the leading causes of death. The use of prebiotics and probiotics can be an alternative treatment against obesity. Although there have been found physiological and biochemical effects of its use, the molecular mechanism remains unclear. The present review analyzed articles that suggested the activation of pathways related to the metabolism of the fatty acids, as well as the impact on anti-inflammatory mechanisms, as part of the mechanism of action of prebiotics and probiotics, to know therefore the possible pathways activated by the prebiotics and probiotics. METHODS: Exhaustive research was made on articles included in the period 2005-2021 related to the effect of prebiotics and probiotics in obesity, inflammatory diseases, and metabolic diseases. Identifying an effect on anti-inflammatory cytokines and PPAR modulation, with a consequent decrease in inflammation and fat degradation. RESULTS: A total of sixty-three articles were obtained, which were classified as basic information on molecular markers of obesity, the effect of prebiotics and probiotics in obesity, and articles related to anti-inflammatory effects and fatty acid metabolism observed in obesity and other inflammatory diseases. CONCLUSIONS: The effect of prebiotics and probiotics in obesity can be linked to the anti-inflammatory mechanism produced, and this effect leads to an increase in the expression of genes related to fatty acid metabolism.

OBJETIVO: La obesidad es una enfermedad ampliamente distribuida en el mundo y resulta una de las principales causas de mortalidad. El uso de prebióticos y probióticos promete una alternativa en el tratamiento de la obesidad, a pesar de los efectos fisiológicos y bioquímicos encontrados, aunque no está aún esclarecido el mecanismo molecular. Por lo que, en la presente revisión, se analizaron artículos que sugerían la activación de vías relacionadas al metabolismo de grasas y azúcares, así como el impacto en los mecanismos antinflamatorios, como parte del mecanismo de acción de los prebióticos y probióticos, con la finalidad de conocer las posibles vías de acción por las cuales se puede obtener el efecto observado. METODOS: Fue realizada una búsqueda exhaustiva de artículos comprendidos en el periodo 2005-2021 relacionados con el efecto de los prebióticos y probióticos en la obesidad y las enfermedades tanto inflamatorias como metabólicas. RESULTADOS: Fueron obtenidos un total de sesenta y tres artículos, los cuales fueron clasificados en: información básica de marcadores moleculares de obesidad; efecto de prebióticos y probióticos en la obesidad; artículos de relación efectos antinflamatorios y metabolismo de grasas observados en la obesidad y otras enfermedades inflamatorias. Se identificó un efecto sobre las citoquinas antinflamatorias y la modulación de los PPAR, con consecuente disminución de la inflamación y degradación de grasas. CONCLUSIONES: El efecto de los prebióticos y probióticos en la obesidad se sugiere está ligado al mecanismo antinflamatorio que producen, lo que a su vez conlleva a un aumento en la expresión de genes relacionados con el metabolismo de grasas.

Association of a Mediterranean Diet and Fruit and Vegetable Consumption with Subjective Well-Being among Adults with Overweight and Obesity.

Recent evidence suggests that among behavioral-lifestyle factors, adherence to a healthy dietary pattern such as the Mediterranean Diet (MedDiet) is linked not only to better psychological health and mental positive status but also to increased subjective well-being (SWB). Nevertheless, this association has been unexplored among individuals with excessive weight. This study explored whether adherence to the MedDiet and the intake of healthy foods such as fruits and vegetables (FV) are associated with increased happiness and life satisfaction among Spanish adults with overweight or obesity when weight, body image, and body satisfaction are also considered. A convenience sample of adult individuals with excessive weight completed self-reports on the study variables, and weight and BMI were measured by bioimpedance. No evidence of a relationship with SWB indicators was obtained for MedDiet global indicators, probably due to the low adherence to a healthy diet by these individuals. In contrast, FV intake, as a powerful indicator of healthy eating, was associated with life satisfaction when BMI and body image dimensions were considered, among which body satisfaction had a key role. Moreover, life satisfaction fully mediated the relationship between FV consumption and happiness. Our findings are expected to make a relevant contribution to knowledge on the positive correlates or protective factors for overall well-being in obesity, including dietary habits and body appreciation. Our results may inform obesity management actions focused on inclusive, positive aesthetic models and promoting a healthy lifestyle for happiness in obesity.

Psychosocial and Diet-Related Lifestyle Clusters in Overweight and Obesity.

This study explored intraindividual multidimensional profiles integrating psychosocial factors, namely, body image and satisfaction, weight-related self-stigma, positivity, and happiness, and behavioural-lifestyle factors, namely, adherence to a healthy diet, among Spanish adults with overweight or obesity. We further aimed to investigate the association of excess weight (i.e., measured body mass index, BMI) with the abovementioned multidimensional configurations. A convenience sample of 100 adult individuals (60% females) with excessive weight (69% overweight; 31% obesity) was recruited. They completed self-reports regarding the study variables, and their weight and height were measured. With a perspective centered on the individual, a cluster analysis was performed. Three distinct intraindividual psychosocial and diet-related profiles were identified: a group of healthy individuals with excess weight (46%); a group of individuals who were negatively affected by their excessive weight and showed the most distressed profile (18%); and a group of dysfunctional individuals who seemed to be excessively unrealistic and optimistic regarding their excessive weight and unhealthy lifestyles, but were troubled by their weight (36%). Furthermore, individuals in the affected cluster had higher obesity (mean BMI ± SD = 32.1 ± 3.7) than those in the clusters of healthy (28.0 ± 3.0) and dysfunctional individuals (28.1 ± 3.3) (p < 0.05). The results showed that there are specific psychosocial and lifestyle profiles in the adult population with excess weight and that there are relationships among psychological, behavioural, and body-composition factors. For clinical application purposes, it is important to account for the heterogeneity within individuals who are obese and to individualize the interventions, with a focus from weight change to the individual's overall well-being.

Agreement between laboratory methods and the 4-compartment model in assessing fat mass in obese older Hispanic-American adults.

BACKGROUND/OBJECTIVES: Densitometry (Siri's and Brozek's equations), hydrometry (by the deuterium dilution technique), and dual-energy X-ray absorptiometry (DXA) are three methods for estimating body composition. However, because they are all based on certain assumptions, they may not be applicable to aged and obese subjects due to changes in their body composition. Hence, the validity of these "laboratory methods" could be affected in obese older people. The main aim was to assess the agreement between densitometry, hydrometry, and DXA with the 4-compartment (4C) model to estimate fat mass (FM) in obese older Hispanic-American adults. As secondary goals, we explored whether the bias in densitometry and hydrometry results could be improved by modifying the assumptions regarding fat-free mass (FFM) density and hydration factor (HF) values, respectively. In the case of DXA, we explored the factors that contribute to bias. SUBJECTS/METHODS: This is a cross-sectional study based on a sample of 171 obese subjects aged ≥60 years from 3 regions of northern Mexico. Body composition was assessed by the 4C model as the reference method and by all three laboratory methods. Agreement of the latter with the 4C model was probed by Bland and Altman analysis, a paired sample t-test, and simple linear regression analyses. In addition, the mean FFM density estimated in this sample, and HF values (published previously) of 0.737 and 0.753 for obese older Hispanic-American men and women, respectively, were considered as ethnic- and gender-specific values. These values were used to modify the densitometric and hydrometric equations in order to improve their bias. Finally, we tested whether the hydration status and indirect markers of adiposity are contributing factors to the bias of DXA using multiple linear regression analysis. RESULTS: Siri's equation overestimated FM by 0.57 kg (p < 0.01), while Brozek's equation, hydrometry, and DXA underestimated it by 1.24 kg, 0.89 kg, and 0.79 kg (p < 0.01), respectively, compared to the 4C model. The bias in the densitometry and hydrometry results was eliminated by substituting the ethnic- and gender-specific values into the equations. Finally, we found that hip circumference contributes to the bias in DXA. CONCLUSION: The densitometry, hydrometry, and DXA methods are not interchangeable with the 4C model for assessing fat mass in obese, older Hispanic-American adults. The lack of agreement could indicate that the assumptions of each method do not apply to this population.

Functionality of Bread and Beverage Added with Brosimum alicastrum Sw. Seed Flour on the Nutritional and Health Status of the Elderly.

Physiological changes in elderly individuals (EI) can contribute to nutritional deterioration and comorbidities that reduce their quality of life. Factors such as diet can modulate some of these effects. The aim was to evaluate the functionality of foods added with Brosimum alicastrum Sw. seed flour in EI. EI (n = 23) living in nursing home conditions agreed to participate. A control stage was carried out (30 days) and subsequently, an intervention stage (30 days) was realized in which a muffin and a beverage, designed for EI, were added to the participants' their usual diet. In both stages, anthropometric parameters, body composition, nutritional status, dietary intake, sarcopenic status, cognitive and affective states, biometric parameters, and total phenolic compounds (TPC), and antioxidant capacity in foods and plasma of EI were determined. The results showed that the consumption of the foods improved the energy intake and preserved the muscle reserves of the EI. The EI gained body weight (+1.1 kg), increased their protein (+18.6 g/day; 1.5 g/kg BW/day), dietary fiber (+13.4 g/day), iron (+4.4 mg/day), zinc (+1.8 mg/day), folic acid (+83.4 µg/day) consumption while reducing their cholesterol (-66 mg/day) and sodium (-319.5 mg/day) consumption. LDL-C lipoproteins reduced (14.8%) and urea (33.1%) and BUN (33.3%) increased. The TPC increased (7.8%) in the plasma, particularly in women (10.7%). The foods improve the EI nutritional status, and this has a cardiovascular protective effect that can benefit the health of the EI.

Considering BMI, Body Image and Desired Weight Change for Suitable Obesity Management Options.

With prevalence of obesity increasing worldwide, understanding body image in individuals with excessive weight is important, as unawareness of weight excess can prevent weight loss attempts. We explored the associations among measured and self-reported body mass index (BMI), body image and body satisfaction among Spanish females and males with overweight or obesity, with a special focus in discriminating individuals who are and are not satisfied with their body and wish or not to change their appearance. Just unifying all individuals with excessive weight may lead to uncover or deny different realities and to develop unfitted clinical management options. Updating findings for the Spanish population, we found that most participants correctly estimated their weight, but 3 in 10 underestimated it. Similarly, their body images corresponded to adults with overweight or obesity who desired to be thinner, but in average they reported a perceived body just slightly overweight and a moderate satisfaction with their body. Complementing the existing evidence, BMI and sex-gender interacted for influencing body weight estimation and desired weight change. In addition, three different subgroups were found for desired change of weight and size, depending on their BMI and body satisfaction. Discovering and considering different subjective realities and corporeal experiences among individuals with weight excess will help professionals to develop appropriate therapeutic interventions. Thus, the personal experiences that individuals have with obesity, instead of obesity itself, should be considered for disentangling management efforts.

Body Satisfaction, Weight Stigma, Positivity, and Happiness among Spanish Adults with Overweight and Obesity.

Although previous evidence suggests that happiness is lower among individuals with obesity, research on the correlates of subjective well-being (SWB) is warranted to increase our knowledge. We aim to explore excess weight (i.e., measured and self-reported body mass index (BMI)), body image and satisfaction, self-stigma, positivity, and happiness among Spanish adults with overweight or obesity. We further aim to investigate the predictors of SWB in this sample. A convenience sample of 100 individuals with excess weight completed self-reports on the study variables and were weighed and their height measured. On average, the participants reported body perceptions revealing minor excessive weight, moderate body satisfaction, low-to-moderate weight-related stigma, and elevated positivity and happiness. BMI and gender/sex independently affected these variables, but there were no significant interaction effects. Furthermore, individuals with overweight or obesity with higher body satisfaction and elevated positivity were more likely to report being happy, independent of their age, gender/sex, weight, and weight-related stigma. Mediation effects were found for body satisfaction and positivity in the relationship between weight and happiness. Moreover, positive orientation suppressed the pervasive influence of stigma on SWB. Our findings confirm the key role of body image dimensions and weight-related stigma for happiness and add support to the relevance of positivity for overall well-being of individuals with excess weight. These results may inform obesity management actions focused on inclusive aesthetic models, combating social stigmatization and enhancing positivity for a flourishing and fulfilling life.

[Consumption of phenolic compounds in the elderly population]. / Ingestión de compuestos fenólicos en población adulta mayor.

INTRODUCTION: Introduction: currently, the elderly population is increasing and with it, the presence of diseases. Phenolic compounds are substances that have antioxidant properties which can impact on the prevention of oxidative damage, closely related to the onset of various diseases. Most phenolic compounds are bioaccessible and bioavailable through mechanical, enzymatic and chemical routes. However, during aging these factors are modified, affecting the absorption of these compounds. Objective: to know the recent information related to the consumption of phenolic compounds and implications for health in the elderly. Methods: a search was made in different academic bases and/or search engines (EBSCOHOST, PubMed and Science Direct) about total phenol consumption in older adults. This information was analyzed and subclassified considering chronic diseases. Results: older adults have an intake of phenolic compounds ranging from 280 ± 130 to 2,771 ± 1,552 mg/day and the amount that reflects a benefit against cardiovascular diseases, metabolic syndrome and diabetes in older adults ranges from 322 ± 153 to 2,861 mg/day. Conclusion: in some cases, the consumption of polyphenols in the elderly is not enough to generate a prevention against different diseases, so increasing their quantity is recommended. There are different situations that modify bioaccessibility and bioavailability, including the deficiency of polyphenol transporters, so the amount needed is modified to carry out its action in the body. There are few studies of this type in this population, so more research is recommended.

INTRODUCCIÓN: Introducción: en la actualidad, la población adulta mayor se encuentra en aumento y, con ello, la presencia de enfermedades. Los compuestos fenólicos son sustancias que tienen propiedades antioxidantes y pueden impactar en la prevención del daño oxidativo, muy relacionado con el inicio de diversas enfermedades. La mayoría de los compuestos fenólicos son bioaccesibles y biodisponibles mediante vías mecánicas, enzimáticas y químicas. Sin embargo, durante el envejecimiento se modifican estos factores afectando la absorción de estos compuestos. Objetivo: conocer la información reciente relacionada con el consumo de compuestos fenólicos y sus implicaciones para la salud en los adultos mayores. Métodos: se realizó una búsqueda en diferentes bases académicas y/o motores de búsqueda (EBSCOHOST, PubMed y Science Direct) sobre consumo total de fenoles en adultos mayores. Esta información fue analizada y subclasificada considerando enfermedades crónicas. Resultados: los adultos mayores tienen una ingesta de compuestos fenólicos que oscila de 280 ± 130 a 2.771 ± 1.552 mg/día y la cantidad que refleja un beneficio frente enfermedades cardiovasculares, síndrome metabólico y diabetes en adultos mayores oscila de 322 ± 153 a 2.861 mg/día. Conclusión: en algunos casos, el consumo de polifenoles en el adulto mayor no es suficiente para generar una prevención frente a diferentes enfermedades, por lo que se recomienda incrementar su cantidad. Existen diferentes situaciones que modifican la bioaccesibilidad y biodisponibilidad, entre ellas la deficiencia de transportadores de polifenoles, por lo que la cantidad necesaria se modifica para llevar a cabo su acción en el organismo. Además, existen pocos estudios de este tipo en esta población, por lo que se recomienda realizar más investigaciones.

High Hydration Factor in Older Hispanic-American Adults: Possible Implications for Accurate Body Composition Estimates.

Age- and obesity-related body composition changes could influence the hydration factor (HF) and, as a result, body composition estimates derived from hydrometry. The aim of the present study was to compare the HF in older Hispanic-American adults to some published values. This cross-sectional study included a sample of 412 subjects, men and women, aged ≥60 years from northern Mexico. HF values were calculated based on the ratio of total body water-using the deuterium dilution technique-to fat-free mass, derived from the four-compartment model. The mean HF value for the total sample (0.748 ± 0.034) was statistically (p ≤ 0.01) higher than the traditionally assumed value of 0.732 derived from chemical analysis, the "grand mean'' value of 0.725 derived from in vivo methods, and the 0.734 value calculated for older French adults via the three-compartment model. The HF of the older women did not differ across the fat mass index categories, but in men the obese group was lower than the normal and excess fat groups. The hydration factor calculated for the total sample of older Hispanic-American people is higher than the HF values reported in the literature. Therefore, the indiscriminate use of these assumed values could produce inaccurate body composition estimates in older Hispanic-American people.

Food neophobia, Mediterranean diet adherence and acceptance of healthy foods prepared in gastronomic workshops by Spanish students.

INTRODUCTION: food neophobia can affect dietary variety and hedonic acceptance due to rejection of healthy foods. OBJECTIVE: to evaluate the impact of dietary neophobia on adherence to the Mediterranean diet and on the hedonic acceptance of healthy foods made in gastronomic workshops by schoolchildren. METHODOLOGY: descriptive cross-sectional study of Primary (8-11) and Secondary (12-18) schoolchildren from Murcia, Spain, participating in gastronomic workshops, where two recipes were prepared and tasted (vegetables + blue fish and fruits). Food neophobia (FN) and adherence to the Mediterranean diet (KIDMED) were identified and each participant assessed the acceptance of each recipe using a hedonic scale (seven points). RESULTS: a total of 1,491 students (49.5% girls) participated in the study; 13.5% were neophobic and 61.1% presented optimal diet quality. A linear inverse relationship between the degree of neophobia and the quality of the diet (ρ[rho] = -0.31, p = 0.001) was found. High adherence to the Mediterranean diet was associated with lower neophobia and better hedonic scores, compared to intermediate or low adhesions (p < 0.0001). Neophobic schoolchildren presented significantly worse results in vegetable consumption, especially at the Secondary level, and in the acceptance of healthy preparations (p < 0.05). A good acceptance of the prepared preparations was associated with the usual adequate consumption of fruits, vegetables, fish and legumes. CONCLUSION: food neophobia affects the adherence to the Mediterranean diet and the acceptance of healthy foods elaborated in gastronomic workshops by Spanish schoolchildren.

Efecto de los prebióticos, probióticos y simbióticos sobre marcadores moleculares de inflamación en la obesidad / Effect of prebiotics, probiotics, and symbiotics on molecular markers of inflammation in obesity

FUNDAMENTOS: La obesidad es una enfermedad ampliamente distribuida en el mundo y resulta una de las principales causas de mortalidad. El uso de prebióticos y probióticos promete una alternativa en el tratamiento de la obesidad, a pesar de los efectos fisiológicos y bioquímicos encontrados, aunque no está aún esclarecido el mecanismo molecular. Por lo que, en la presente revisión, se analizaron artículos que sugerían la activación de vías relacionadas al metabolismo de grasas y azúcares, así como el impacto en los mecanismos antinflamatorios, como parte del mecanismo de acción de los prebióticos y probióticos, con la finalidad de conocer las posibles vías de acción por las cuales se puede obtener el efecto observado. MÉTODOS: Fue realizada una búsqueda exhaustiva de artículos comprendidos en el periodo 2005-2021 relacionados con el efecto de los prebióticos y probióticos en la obesidad y las enfermedades tanto inflamatorias como metabólicas. RESULTADOS: Fueron obtenidos un total de sesenta y tres artículos, los cuales fueron clasificados en: información básica de marcadores moleculares de obesidad; efecto de prebióticos y probióticos en la obesidad; artículos de relación efectos antinflamatorios y metabolismo de grasas observados en la obesidad y otras enfermedades inflamatorias. Se identificó un efecto sobre las citoquinas antinflamatorias y la modulación de los PPAR, con consecuente disminución de la inflamación y degradación de grasas. CONCLUSIONES: El efecto de los prebióticos y probióticos en la obesidad se sugiere está ligado al mecanismo antinflamatorio que producen, lo que a su vez conlleva a un aumento en la expresión de genes relacionados con el metabolismo de grasas.(AU)

BACKGROUND: Obesity is an inflammatory disease that is widely distributed in the world’s population and is related to the leading causes of death. The use of prebiotics and probiotics can be an alternative treatment against obesity. Although there have been found physiological and biochemical effects of its use, the molecular mechanism remains unclear. The present review analyzed articles that suggested the activation of pathways related to the metabolism of the fatty acids, as well as the impact on anti-inflammatory mechanisms, as part of the mechanism of action of prebiotics and probiotics, to know therefore the possible pathways activated by the prebiotics and probiotics. METHODS: Exhaustive research was made on articles included in the period 2005-2021 related to the effect of prebiotics and probiotics in obesity, inflammatory diseases, and metabolic diseases. Identifying an effect on anti-inflammatory cytokines and PPAR modulation, with a consequent decrease in inflammation and fat degradation. RESULTS: A total of sixty-three articles were obtained, which were classified as basic information on molecular markers of obesity, the effect of prebiotics and probiotics in obesity, and articles related to anti-inflammatory effects and fatty acid metabolism observed in obesity and other inflammatory diseases. CONCLUSIONS: The effect of prebiotics and probiotics in obesity can be linked to the anti-inflammatory mechanism produced, and this effect leads to an increase in the expression of genes related to fatty acid metabolism.(AU)

Abdominal obesity is strongly associated to blood pressure in young Mexicans.

OBJECTIVE: The objective of this study was to determine associations between abdominal obesity (AOb) and the other components of metabolic syndrome (MetS) in young Mexicans in a cross-sectional survey completed during a 4 year period. METHODS: This cross-sectional study reports on components and prevalence of MetS by using Alberti et al. (16) criteria, as well as association between AOb and elevated blood pressure (BP) of 2,993 Mexican university students, ages 17 to 25 years (66% women) from central and northern Mexico, over a 4-year survey (2010-2013). RESULTS: The most prevalent MetS components in the total sample were low HDL-C concentration (43.6%) and AOb (41.1%). MetS prevalence was 11.8%, more men than women were classified with MetS (14.3% vs. 10.5%, p < 0.01). BP was the MetS component with the lowest prevalence (8.6%). A strong association between AOb and altered BP with in both men and women was found (OR 4.3, IC95% 2.5-7.4). CONCLUSIONS: Even BP was the component with the lowest prevalence, AOb was more strongly associated with it. This fact, could explain the prevalence of hypertension among young Mexican adults.

[Not Available]. / Adherencia a la dieta mediterránea y su relación con la calidad del desayuno en estudiantes de la Universidad de Murcia.

Introducción y objetivos: la evolución que ha experimentado en los últimos años la sociedad española ha originado una serie de cambios sociológicos y/o culturales que afectan claramente a los hábitos y preferencias alimentarias. El objetivo del presente trabajo ha sido evaluar la adherencia a la dieta mediterránea (DM) de la población universitaria en la ciudad de Murcia y la calidad de su desayuno, estableciendo la relación existente entre estas dos variables entre sí, y otras variables sociológicas analizadas.Métodos: se evaluó la adherencia a la DM en una muestra de 312 estudiantes mediante el test KIDMED, cuestionario de 16 preguntas. La calidad del desayuno fue determinada en función de la ingesta de los distintos grupos de alimentos (lácteos, cereales y frutas), de forma que se establecieron las siguientes categorías de calidad: pésima, mala, regular y buena. De cada encuestado se registraron los datos personales, lugar de origen, zona geográfica y tipo de residencia, sexo, edad, titulación universitaria, curso y las variables antropométricas (peso, altura, perímetro de cintura y cadera).Resultados: la muestra estuvo formada por 238 mujeres y 74 hombres todos ellos estudiantes universitarios de distintos títulos de grado. El 7,85% de los universitarios mostró una baja adherencia a la DM, el 48,4% media y el 43,8% alta. Los estudiantes de grado en Educación Primaria mostraron una mayor adherencia media a la DM; los estudiantes de grado en Enfermería tomaron más de una ración de verdura al día; y los de Ciencia y Tecnología de los Alimentos consumían una pieza de fruta al día. Teniendo en cuenta el sexo de los participantes, el 37,8% de las mujeres tomaban más de una verdura diaria y el 91,5% desayunaba bollería industrial; mientras que el 54,1% de los hombres tomaban frutos secos (al menos 2 o 3 veces por semana) y el 74,5% desayunaba todos los días. El 1,15% de los estudiantes mostró una calidad del desayuno pésima, el 17,65% mala, el 60,65% regular y el 20,45% buena, coincidiendo la buena calidad con el consumo de fruta en esta comida. Además, se observó una asociación significativa entre el tiempo y la calidad del desayuno, ya que aquellos estudiantes que dedicaban más de diez minutos a desayunar tomaban un desayuno de buena calidad.Conclusión: en este estudio se ha visto que la calidad del desayuno está estrechamente relacionada con el grado de adherencia al patrón dietético mediterráneo.

Ingestión de compuestos fenólicos en población adulta mayor / Consumption of phenolic compounds in the elderly population

Introducción: en la actualidad, la población adulta mayor se encuentra en aumento y, con ello, la presencia de enfermedades. Los compuestos fenólicos son sustancias que tienen propiedades antioxidantes y pueden impactar en la prevención del daño oxidativo, muy relacionado con el inicio de diversas enfermedades. La mayoría de los compuestos fenólicos son bioaccesibles y biodisponibles mediante vías mecánicas, enzimáticas y químicas. Sin embargo, durante el envejecimiento se modifican estos factores afectando la absorción de estos compuestos. Objetivo: conocer la información reciente relacionada con el consumo de compuestos fenólicos y sus implicaciones para la salud en los adultos mayores. Métodos: se realizó una búsqueda en diferentes bases académicas y/o motores de búsqueda (EBSCOHOST, PubMed y Science Direct) sobre consumo total de fenoles en adultos mayores. Esta información fue analizada y subclasificada considerando enfermedades crónicas. Resultados: los adultos mayores tienen una ingesta de compuestos fenólicos que oscila de 280 ± 130 a 2.771 ± 1.552 mg/día y la cantidad que refleja un beneficio frente enfermedades cardiovasculares, síndrome metabólico y diabetes en adultos mayores oscila de 322 ± 153 a 2.861 mg/día. Conclusión: en algunos casos, el consumo de polifenoles en el adulto mayor no es suficiente para generar una prevención frente a diferentes enfermedades, por lo que se recomienda incrementar su cantidad. Existen diferentes situaciones que modifican la bioaccesibilidad y biodisponibilidad, entre ellas la deficiencia de transportadores de polifenoles, por lo que la cantidad necesaria se modifica para llevar a cabo su acción en el organismo. Además, existen pocos estudios de este tipo en esta población, por lo que se recomienda realizar más investigaciones

Introduction: currently, the elderly population is increasing and with it, the presence of diseases. Phenolic compounds are substances that have antioxidant properties which can impact on the prevention of oxidative damage, closely related to the onset of various diseases. Most phenolic compounds are bioaccessible and bioavailable through mechanical, enzymatic and chemical routes. However, during aging these factors are modified, affecting the absorption of these compounds. Objective: to know the recent information related to the consumption of phenolic compounds and implications for health in the elderly. Methods: a search was made in different academic bases and/or search engines (EBSCOHOST, PubMed and Science Direct) about total phenol consumption in older adults. This information was analyzed and subclassified considering chronic diseases. Results: older adults have an intake of phenolic compounds ranging from 280 ± 130 to 2,771 ± 1,552 mg/day and the amount that reflects a benefit against cardiovascular diseases, metabolic syndrome and diabetes in older adults ranges from 322 ± 153 to 2,861 mg/day. Conclusion: in some cases, the consumption of polyphenols in the elderly is not enough to generate a prevention against different diseases, so increasing their quantity is recommended. There are different situations that modify bioaccessibility and bioavailability, including the deficiency of polyphenol transporters, so the amount needed is modified to carry out its action in the body. There are few studies of this type in this population, so more research is recommended

Neofobia alimentaria y trastornos de conducta alimentaria: Impacto en la adherencia a la dieta mediterránea de universitarios españoles / Food neophobia and eating disorders: Impact on adherence to the Mediterranean diet of Spanish university students

RESUMEN Este estudio evaluó la actitud de los universitarios murcianos hacia los nuevos alimentos y su relación con la adherencia a la dieta mediterránea, el riesgo de alteraciones de la conducta alimentaria y su asociación con la masa corporal. Participaron estudiantes de la Universidad de Murcia a los cuales se realizaron mediciones antropométricas, peso y talla, para estimar el índice de masa corporal y se estableció su condición nutricional, y se aplicaron las encuestas para identificación de trastornos de conducta alimentaria y neofobia alimentaria. Participaron un total de 300 universitarios con un promedio de edad de 21.3 años. Sólo el 14% de las mujeres y 35% de los hombres presentaron exceso de peso. Un 44% presentan buena adherencia a la dieta mediterránea. La Neofobia fue ligeramente mayor en mujeres que en hombres. Entre los resultados se identificó que existen más conductas de trastornos de conducta alimentaria (15.5%) que neofobia (11.5%), impactando negativamente a la adherencia a la dieta mediterránea. Los universitarios de la Región de Murcia, presentan una puntuación en trastorno de la conducta alimentaria inferior a la reportada por otros autores, no existiendo diferencias significativas entre esta y el sexo, la adherencia a la dieta mediterránea o el IMC.

ABSTRACT The study was designed to evaluate the attitude of Spanish undergraduates towards new foods and its impact on adherence to the Mediterranean diet, risk of altered eating behavior and its association with body mass. Undergraduates of the University of Murcia were invited to participate. Anthropometry (weight and height) was measured to estimate body mass and nutritional status and surveys were administered to identify eating disorders and food neophobia. A total of 300 undergraduates participated, with a mean age of 21.3 years. Only 14% of the women and 35% of the men were overweight; 44% had good adherence to the Mediterranean diet. Neophobia is slightly higher in females than males. We observed more eating disorder behaviors (15.5%) compared to food neophobia (11.5%) and that both negatively impacted the adherence to the Mediterranean diet. Undergraduates from the Murcia Region, reported an eating disorder values lower than that reported by other authors. No significant differences were found between this and sex, adherence to the Mediterranean diet or BMI.