RESUMO
Fibrochondrogenesis is a rare, neonatally lethal rhizomelic chondrodysplasia distinguished from other forms of lethal dwarfism by broad long-bone metaphyses, pear-shaped vertebral bodies, and by microscopic changes of cartilage with unique interwoven fibrous septa and fibroblastic dysplasia of chondrocytes. We report the second and third well-documented cases of this apparently autosomal recessive disorder and discuss the differential diagnosis.
Assuntos
Osteocondrodisplasias/genética , Cartilagem/patologia , Feminino , Genes Letais , Genes Recessivos , Lâmina de Crescimento/ultraestrutura , Humanos , Recém-Nascido , Osteocondrodisplasias/diagnóstico por imagem , Osteocondrodisplasias/patologia , RadiografiaRESUMO
Sixty seven patients with coexistent tuberculosis and hepatitis were given a 3 drug regimen of streptomycin (SM), isonicotinic acid hydrazide (INH) and ethambutol (ETB) and observed for a period of 15 days. Total bilirubin as well as SGPT were repeated weekly and these showed a significant drop in a majority of patients when observed over this period. No patient developed any signs of fulminant hepatic failure. We conclude that a regimen of SM, INH and ETB can be given to patients who suffer from combined pathologies of pulmonary tuberculosis and active hepatitis without incurring the danger of increasing hepatocellular dysfunction/damage.