Venus: mapping the surface reflectivity by radar interferometry.

The surface reflectivity of Venus obtained by radar interferometry at a wavelength of 3.8 centimeters has been mapped for a region extending approximately from -80 degrees to 0 degrees in longitude (Carpenter's definition) and from -50 degrees to +40 degrees in latitude. The map is free from the twofold range-Doppler ambiguity because the interferometer fringe pattern makes possible the separation of two points of equal range and Doppler shift. The map presents many new features and clearly delineates features already observed. Most notably, the map shows large circular regions of significantly lower reflectivity than their surroundinigs.

Martian craters and a scarp as seen by radar.

Radar observations of Mars with a surface resolution of 1.3 degrees in latitude and 0.8 degrees in longitude have been carried out during the opposition of 1971. With a precision in surface height measurement approaching 75 meters in regions of high reflectivity, it has been possible to measure the detailed characteristics of a number of craters. Many of these can be identified with craters shown in Mariner photographs of Mars. In addition, a scarp has been seen at 41 degrees west, 14 degrees south with an average slope of about 6 degrees extending over about 40 kilometers.

Venus: radar determination of gravity potential.

We describe a method for the determination of the gravity potential of Venus from multiple-frequency radar measurements. The method is based on the strong frequency dependence of the absorption of radio waves in Venus' atmosphere. Comparison of the differing radar reflection intensities at several frequencies yields the height of the surface relative to a reference pressure contour; combination with measurements of round-trip echo delays allows the pressure, and hence the gravity potential contour, to be mapped relative to the mean planet radius. Since calibration data from other frequencies are unavailable, the absorption-sensitive Haystack Observatory data have been analyzed under the assumption of uniform surface reflectivity to yield a gravity equipotential contour for the equatorial region and a tentative upper bound of 6 x 10(-4) on the fractional difference of Venus' principal equatorial moments of inertia. The minima in the equipotential contours appear to be associated with topographic minima.

Detection of a Compact Radio Source near the Center of a Gravitational Lens: Quasar Image or Galactic Core?

By use of a new, very sensitive interferometric system, a faint, compact radio source has been detected near the center of the galaxy that acts as the main part of a gravitational lens. This lens forms two previously discovered images of the quasar Q09S7+561, which lies in the direction of the constellation Ursa Major. The newly detected source has a core smaller than 0.002 arc second in diameter with a flux density of 0.6 +/- 0.1 millijansky at the 13-centimeter wavelength of the radio observations. This source could be the predicted third image of the transparent gravitational lens, the central core of the galaxy, or some combination of the two. It is not yet possible to choose reliably between these alternatives.

Spectral line interferometry with independent time standards at stations separated by 845 kilometers.

An upper limit of 0.02 second of arc has been determined for a hydroxyl radical (OH) emission region associated with the radio source W3, with the use of a Michelson interferometer consisting of two radio telescopes 845 kilometers apart. Timing was provided at the stations by independent atomic frequency standards. The 1665-megahertz radiation was translated to video frequency and recorded digitally on magnetic tapes which were later processed by computer, yielding fringe phase and amplitude as a function of frequency over the received bandwidth.

Transcontinental baselines and the rotation of the Earth measured by radio interferometry.

Nine separate very-long-baseline interferometry (VLBI) experiments, carried out in 1972 and 1973 with radio telescopes 3900 kilometers apart, yielded values for the baseline length with a root-mean-square deviation about the mean of less than 20 centitneters. The corresponding fractional spread is about five parts in 10(8). Changes in universal time and in polar motion were also detertnined accurately from these data; the root-mean-square scatter of these results with respect to those based on optical methods were 2.9 milliseconds and 1.3 meters, respectively. Solid-earth tides were apparently detected, but no useful estimate of their amplituide was extracted.

Quasars: Millisecond-of-Arc Structure Revealed by Very-Long-Baseline Interferometry.

Observations with the Goldstone-Haystack radio interferometer of the quasars 3C 279 and 3C 273 have disclosed the presence of fine structure in their radio emissions. Although the interpretation is not unique, the fringe-amplitude data for quasar 3C 279 are quite consistent with emissions from two points, each contributing equally to the correlated flux. The separation of the two points is estimated to be (1.55 +/- 0.05) x 10(-3) arc second, or about 20 light years at the distance of 3 x 10(9) light years inferred from optical red-shift data. The formal uncertainty in the right-ascension component of the separation is about 6 x 10(-6) arc second; differential proper motion in this direction at half the speed of light could be discerned within a year. The fringe-amplitude data of quasar 3C 273 allow similar, but less definitive, interpretations.

Quasars revisited: rapid time variations observed via very-long-baseline interferometry.

Recent Goldstone-Haystack radio interferometric observations of the quasars 3C 279 and 3C 273 reveal rapid variations in their fine structure. Most notably, the data for 3C 279, interpreted in terms of a symmetric double-source model and the accepted red-shift distance, indicate differential proper motion corresponding to an apparent speed about ten times that of light. A number of possible mechanisms that might give rise to such an apparent speed are considered; although several may be plausible, no definitive choice can be made on the basis of present evidence. More interferometric observations of quasars are clearly needed to clarify their structure and internal kinematics.

Precision Geodesy via Radio Interferometry.

Very-long-baseline interferometry experiments, involving observations of extragalactic radio sources, were performed in 1969 to determine the vector separations between antenna sites in Massachusetts and West Virginia. The 845.130-kilometer baseline was estimated from two separate experiments. The results agreed with each other to within 2 meters in all three components and with a special geodetic survey to within 2 meters in length; the differences in baseline direction as determined by the survey and by interferometry corresponded to discrepancies of about 5 meters. The experiments also yielded positions for nine extragalactic radio sources, most to within 1 arc second, and allowed the hydrogen maser clocks at the two sites to be synchronized a posteriori with an uncertainty of only a few nanoseconds.

Interferometric observations of an artificial satellite.

Very-long-baseline interferometric observations of radio signals from the TACSAT synchronous satellite, even though extending over only 7 hours, have enabled an excellent orbit to be deduced. Precision in differenced delay and delay-rate measurements reached 0.15 nanosecond ( approximately 5 centimeters in equivalent differenced distance) and 0.05 picosecond per second ( approximately 0.002 centimeter per second in equivalent differenced velocity), respectively. The results from this initial three-station experiment demonstrate the feasibility of using the method for accurate satellite tracking and for geodesy. Comparisons are made with other techniques.

Very long baseline interferometric observations made with an orbiting radio telescope.

An orbiting spacecraft and ground observatories have been used to obtain interferometric observations of cosmic radio sources. The Tracking and Data Relay Satellite System (TDRSS) was used as the orbiting observatory in conjunction with two 64- meter radio telescopes at ground observatories, one in Australia and one in Japan. The quasars 1730-130 (NRAO 530), 1510-089, and 1741-038 were observed at a frequency of 2.3 gigahertz, and a maximum projected baseline of 1.4 earth diameters was achieved. All quasar observations for which valid data were acquired resulted in detected fringes. Many of the techniques proposed for a dedicated very long baseline interferometry observatory in space were used successfully in this experiment.

Very-Long-Baseline Radio Interferometry: The Mark III System for Geodesy, Astrometry, and Aperture Synthesis.

The Mark III very-long-baseline interferometry (VLBI) system allows recording and later processing of up to 112 megabits per second from each radio telescope of an interferometer array. For astrometric and geodetic measurements, signals from two radio-frequency bands (2.2 to 2.3 and 8.2 to 8.6 gigahertz) are sampled and recorded simultaneously at all antenna sites. From these dual-band recordings the relative group delays of signals arriving at each pair of sites can be corrected for the contributions due to the ionosphere. For many radio sources for which the signals are sufficiently intense, these group delays can be determined with uncertainties under 50 picoseconds. Relative positions of widely separated antennas and celestial coordinates of radio sources have been determined from such measurements with 1 standard deviation uncertainties of about 5 centimeters and 3 milliseconds of arc, respectively. Sample results are given for the lengths of baselines between three antennas in the United States and three in Europe as well as for the arc lengths between the positions of six extragalactic radio sources. There is no significant evidence of change in any of these quantities. For mapping the brightness distribution of such compact radio sources, signals of a given polarization, or of pairs of orthogonal polarizations, can be recorded in up to 28 contiguous bands each nearly 2 megahertz wide. The ability to record large bandwidths and to link together many large radio telescopes allows detection and study of compact sources with flux densities under 1 millijansky.

A toxicologic and dermatologic assessment of cyclic acetates when used as fragrance ingredients.

An evaluation and review of a structurally related group of fragrance materials.

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

Expression of nuclear factor-kappaB (NF-kappaB)/Rel transcription factors has recently been found to promote cell survival, inhibiting the induction of apoptosis. In most cells other than B lymphocytes, NF-kappaB/Rel is inactive, sequestered in the cytoplasm. For example, nuclear extracts from two human untransformed breast epithelial cell lines expressed only very low levels of NF-kappaB. Unexpectedly, nuclear extracts from two human breast tumor cell lines displayed significant levels of NF-kappaB/Rel. Direct inhibition of this NF-kappaB/ Rel activity in breast cancer cells induced apoptosis. High levels of NF-kappaB/Rel binding were also observed in carcinogen-induced primary rat mammary tumors, whereas only expectedly low levels were seen in normal rat mammary glands. Furthermore, multiple human breast cancer specimens contained significant levels of nuclear NF-kappaB/Rel subunits. Thus, aberrant nuclear expression of NF-kappaB/Rel is associated with breast cancer. Given the role of NF-kappaB/Rel factors in cell survival, this aberrant activity may play a role in tumor progression, and represents a possible therapeutic target in the treatment of these tumors.

A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients.

An evaluation and review of a structurally related group of fragrance materials.

A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients.

An evaluation and review of a structurally related group of fragrance materials.

A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients.

An evaluation and review of a structurally related group of fragrance materials.

Hepatic prolactin binding in female Sprague-Dawley rats fed a diet high in corn oil.

The relationship between dietary fat content and hepatic prolactin (PRL) binding during the four stages of the estrous cycle was examined. Serum 17 beta-estradiol, PRL, and progesterone were also monitored in the same animals. Female SD rats were fed 5 or 24% corn oil in nutritionally balanced diets, given 2.5 mg 7,12-dimethylbenz[a]anthracene [(DMBA) CAS: 57-97-6] or vehicle by gavage at 8 weeks of age, and decapitated at noon on 1 of the 4 days of the estrous cycle 2-5 weeks later. Analysis of hepatic PRL binding data by Scatchard plots revealed no effect of diet or DMBA. PRL binding was lowest at proestrus, increased at estrus, remained elevated at metestrus, and declined at diestrus. Diet also had no effect on serum hormone concentrations, which showed the expected pattern during the estrous cycle in all treatment groups. Results reported by others of an effect of dietary corn oil content on hepatic PRL binding may have been due to use of control diets low in essential fatty acids.

Effect of BCG on dimethylhydrazine induction of colon tumors in rats.

The effect of BCG injection into the colon wall on the induction of colon tumors by 1,2-dimethylhydrazine dihydrochloride (DMH) was assessed in male rats. Persistent, generalized BCG infection followed the intracolonic injection of 6.7 times 10(6) organisms in otherwise untreated rats. In rats given DMH (30 mg/kg/wk) intragastrically for 5 weeks and then infected with BCG, colon tumors developed at the same rate and in the same incidence as in uninfected rats, but more tumors were mucinous adenocarcinomas and metastasized to the abdominal lymph nodes. In a few rats with large, established colon tumors, the injection of BCG into tumors induced no apparent change in them when examined at autopsy 1-22 weeks later.

Immunologic aspects of 1, 2-dimethylhydrazine-induced colon tumors in rats.

Investigation of immunologic aspects of colon tumors induced in rats by 1,2-dimethylhydrazine demonstrated that: 1) An antigen in an extract of colon tumors was not detected in the normal colon. It was related to antigens in rat fetuses and did not cross-react immunologically with carcinoembryonic antigen. 2) Mucinous adenocarcinomas of the colon were significantly associated spatially with lymphoid follicles.