Detalhe da pesquisa
1.
PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.
Mol Cell
; 60(4): 571-83, 2015 Nov 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26481663
2.
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
J Am Chem Soc
; 141(21): 8450-8461, 2019 05 29.
Artigo
Inglês
| MEDLINE | ID: mdl-31059257
3.
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Am J Respir Cell Mol Biol
; 58(5): 585-593, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29019702
4.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(6): 452-8, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27110680
5.
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Bioorg Med Chem
; 26(8): 1727-1739, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29555419
6.
Structure activity relationships of human galactokinase inhibitors.
Bioorg Med Chem Lett
; 25(3): 721-7, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25553891
7.
Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(8): 656, 2016 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-27434767
8.
Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections".
ACS Cent Sci
; 8(9): 1362, 2022 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-36188352
9.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
J Med Chem
; 64(8): 4913-4946, 2021 04 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33822623
10.
Total synthesis of (+/-)- and (-)-actinophyllic acid.
J Am Chem Soc
; 132(13): 4894-906, 2010 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-20218696
11.
Total synthesis of (+)-nankakurines A and B and (±)-5-epi-nankakurine A.
J Org Chem
; 75(22): 7519-34, 2010 Nov 19.
Artigo
Inglês
| MEDLINE | ID: mdl-20958075
12.
EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.
Mol Cancer Ther
; 19(7): 1520-1529, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32371575
13.
Total synthesis of (+/-)-actinophyllic acid.
J Am Chem Soc
; 130(24): 7568-9, 2008 Jun 18.
Artigo
Inglês
| MEDLINE | ID: mdl-18491907
14.
Enantioselective total syntheses of nankakurines A and B: confirmation of structure and establishment of absolute configuration.
J Am Chem Soc
; 130(34): 11297-9, 2008 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-18680252
15.
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Sci Rep
; 7(1): 12758, 2017 10 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28986582
16.
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
ACS Med Chem Lett
; 7(5): 465-9, 2016 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27190594
17.
Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.
ACS Chem Biol
; 11(11): 3214-3225, 2016 11 18.
Artigo
Inglês
| MEDLINE | ID: mdl-27552339