Detalhe da pesquisa
1.
KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation.
Int J Mol Sci
; 25(2)2024 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38256028
2.
Synergistic effect of compounds directed to triosephosphate isomerase, a combination to develop drug against trichomoniasis.
Arch Pharm (Weinheim)
; 355(6): e2200046, 2022 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-35332589
3.
Leukocyte Nuclear Morphology Alterations in Dilated Cardiomyopathy Caused by a Lamin AC Truncating Mutation (LMNA/Ser431*) Are Modified by the Presence of a LAP2 Missense Polymorphism (TMPO/Arg690Cys).
Int J Mol Sci
; 23(21)2022 Nov 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36362411
4.
Laccases: structure, function, and potential application in water bioremediation.
Microb Cell Fact
; 18(1): 200, 2019 Nov 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31727078
5.
KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer.
BMC Cancer
; 18(1): 1299, 2018 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30594165
6.
The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo.
BMC Cancer
; 18(1): 1056, 2018 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30382908
7.
A new nucleocytoplasmic RhoGAP protein contributes to control the pathogenicity of Entamoeba histolytica by regulating EhRacC and EhRacD activity.
Cell Microbiol
; 18(11): 1653-1672, 2016 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-27107405
8.
Discovery of Entamoeba histolytica hexokinase 1 inhibitors through homology modeling and virtual screening.
J Enzyme Inhib Med Chem
; 29(3): 325-32, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23534932
9.
Inhibition and biochemical characterization of methicillin-resistant Staphylococcus aureus shikimate dehydrogenase: an in silico and kinetic study.
Molecules
; 19(4): 4491-509, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24727420
10.
Antineoplastic effect of compounds C14 and P8 on TNBC and radioresistant TNBC cells by stabilizing the K-Ras4BG13D/PDE6δ complex.
Front Oncol
; 14: 1341766, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38571493
11.
Hen lysozyme fibrillogenesis, molten globule intermediate and effect of copper salts.
J Biomol Struct Dyn
; 41(2): 423-434, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34821199
12.
Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer.
Life Sci Alliance
; 6(12)2023 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37813486
13.
Consequences of two naturally occurring missense mutations in the structure and function of Bruton agammaglobulinemia tyrosine kinase.
IUBMB Life
; 64(4): 346-53, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22378381
14.
Conformational dynamics of L-lysine, L-arginine, L-ornithine binding protein reveals ligand-dependent plasticity.
Proteins
; 79(7): 2097-108, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21538545
15.
Triosephosphate isomerase as a therapeutic target against trichomoniasis.
Mol Biochem Parasitol
; 246: 111413, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34537286
16.
Design of thermostable beta-propeller phytases with activity over a broad range of pHs and their overproduction by Pichia pastoris.
Appl Environ Microbiol
; 76(19): 6423-30, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20693453
17.
A plasmid encoding parts of the dengue virus E and NS1 proteins induces an immune response in a mouse model.
Arch Virol
; 155(6): 847-56, 2010 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-20390312
18.
Enthalpically-driven ligand recognition and cavity solvation of bovine odorant binding protein.
Biophys Chem
; 257: 106315, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31841862
19.
Engineering and directed evolution of a Ca2+ binding site A-deficient AprE mutant reveal an essential contribution of the loop Leu75-Leu82 to enzyme activity.
J Biomed Biotechnol
; 2009: 201075, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-19710937
20.
Selective inactivation of triosephosphate isomerase from Trypanosoma cruzi by brevifolin carboxylate derivatives isolated from Geranium bellum Rose.
Bioorg Med Chem Lett
; 19(20): 5936-9, 2009 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19733070