Detalhe da pesquisa
1.
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
Bioorg Med Chem Lett
; 24(6): 1466-71, 2014 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24582987
2.
Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.
Bioorg Med Chem Lett
; 24(8): 1968-73, 2014 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24666646
3.
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.
Bioorg Med Chem Lett
; 24(3): 1000-1004, 2014 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24412070
4.
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead.
Bioorg Med Chem Lett
; 20(24): 7421-5, 2010 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21044843
5.
Quality control procedures for dose-response curve generation using nanoliter dispense technologies.
J Biomol Screen
; 12(6): 891-9, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17517899
6.
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J Med Chem
; 56(6): 2294-310, 2013 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23379595
7.
Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.
J Med Chem
; 54(20): 7334-49, 2011 Oct 27.
Artigo
Inglês
| MEDLINE | ID: mdl-21942426
8.
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
J Med Chem
; 54(12): 4092-108, 2011 Jun 23.
Artigo
Inglês
| MEDLINE | ID: mdl-21608528