Pesquisa | Secretaria de Estado da Saúde

1.

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

McMillan, Elizabeth A; Ryu, Myung-Jeom; Diep, Caroline H; Mendiratta, Saurabh; Clemenceau, Jean R; Vaden, Rachel M; Kim, Ju-Hwa; Motoyaji, Takashi; Covington, Kyle R; Peyton, Michael; Huffman, Kenneth; Wu, Xiaofeng; Girard, Luc; Sung, Yeojin; Chen, Pei-Hsaun; Mallipeddi, Prema L; Lee, Joo Young; Hanson, Jordan; Voruganti, Sukesh; Yu, Yunku; Park, Sunho; Sudderth, Jessica; DeSevo, Christopher; Muzny, Donna M; Doddapaneni, HarshaVardhan; Gazdar, Adi; Gibbs, Richard A; Hwang, Tae-Hyun; Heymach, John V; Wistuba, Ignacio; Coombes, Kevin R; Williams, Noelle S; Wheeler, David A; MacMillan, John B; Deberardinis, Ralph J; Roth, Michael G; Posner, Bruce A; Minna, John D; Kim, Hyun Seok; White, Michael A.

Cell ; 173(4): 864-878.e29, 2018 05 03.

Artigo Inglês | MEDLINE | ID: mdl-29681454

2.

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.

Kim, Hyun Seok; Mendiratta, Saurabh; Kim, Jiyeon; Pecot, Chad Victor; Larsen, Jill E; Zubovych, Iryna; Seo, Bo Yeun; Kim, Jimi; Eskiocak, Banu; Chung, Hannah; McMillan, Elizabeth; Wu, Sherry; De Brabander, Jef; Komurov, Kakajan; Toombs, Jason E; Wei, Shuguang; Peyton, Michael; Williams, Noelle; Gazdar, Adi F; Posner, Bruce A; Brekken, Rolf A; Sood, Anil K; Deberardinis, Ralph J; Roth, Michael G; Minna, John D; White, Michael A.

Cell ; 155(3): 552-66, 2013 Oct 24.

Artigo Inglês | MEDLINE | ID: mdl-24243015

3.

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.

Wang, May-Yun; Yu, Xinxin; Lee, Young; McCorkle, Sara Kay; Chen, Shiuhwei; Li, Jianping; Wang, Zhao V; Davidson, Jaime A; Scherer, Philipp E; Holland, William L; Unger, Roger H; Roth, Michael G.

Proc Natl Acad Sci U S A ; 114(25): 6611-6616, 2017 06 20.

Artigo Inglês | MEDLINE | ID: mdl-28584109

4.

Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation.

Díaz-Martínez, Laura A; Karamysheva, Zemfira N; Warrington, Ross; Li, Bing; Wei, Shuguang; Xie, Xian-Jin; Roth, Michael G; Yu, Hongtao.

EMBO J ; 33(17): 1960-76, 2014 Sep 01.

Artigo Inglês | MEDLINE | ID: mdl-25024437

5.

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.

Wang, May-Yun; Yan, Hai; Shi, Zhiqing; Evans, Matthew R; Yu, Xinxin; Lee, Young; Chen, Shiuhwei; Williams, Annie; Philippe, Jacques; Roth, Michael G; Unger, Roger H.

Proc Natl Acad Sci U S A ; 112(8): 2503-8, 2015 Feb 24.

Artigo Inglês | MEDLINE | ID: mdl-25675519

6.

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.

Lee, Young; Berglund, Eric D; Yu, Xinxin; Wang, May-Yun; Evans, Matthew R; Scherer, Philipp E; Holland, William L; Charron, Maureen J; Roth, Michael G; Unger, Roger H.

Proc Natl Acad Sci U S A ; 111(36): 13217-22, 2014 Sep 09.

Artigo Inglês | MEDLINE | ID: mdl-25157166

7.

Glucagon therapeutics: Dawn of a new era for diabetes care.

Davidson, Jaime A; Holland, William L; Roth, Michael G; Wang, May-Yun; Lee, Young; Yu, Xinxin; McCorkle, Sara K; Scherer, Philipp E; Unger, Roger H.

Diabetes Metab Res Rev ; 32(7): 660-665, 2016 10.

Artigo Inglês | MEDLINE | ID: mdl-26729301

8.

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.

Mata, Miguel A; Satterly, Neal; Versteeg, Gijs A; Frantz, Doug; Wei, Shuguang; Williams, Noelle; Schmolke, Mirco; Peña-Llopis, Samuel; Brugarolas, James; Forst, Christian V; White, Michael A; García-Sastre, Adolfo; Roth, Michael G; Fontoura, Beatriz M A.

Nat Chem Biol ; 7(10): 712-9, 2011 Sep 11.

Artigo Inglês | MEDLINE | ID: mdl-21909097

9.

Synthetic lethal screen identification of chemosensitizer loci in cancer cells.

Whitehurst, Angelique W; Bodemann, Brian O; Cardenas, Jessica; Ferguson, Deborah; Girard, Luc; Peyton, Michael; Minna, John D; Michnoff, Carolyn; Hao, Weihua; Roth, Michael G; Xie, Xian-Jin; White, Michael A.

Nature ; 446(7137): 815-9, 2007 Apr 12.

Artigo Inglês | MEDLINE | ID: mdl-17429401

10.

Small molecule glucagon release inhibitors with activity in human islets.

Kalwat, Michael A; Rodrigues-Dos-Santos, Karina; Binns, Derk D; Wei, Shuguang; Zhou, Anwu; Evans, Matthew R; Posner, Bruce A; Roth, Michael G; Cobb, Melanie H.

Front Endocrinol (Lausanne) ; 14: 1114799, 2023.

Artigo Inglês | MEDLINE | ID: mdl-37152965

11.

Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.

Wu, Cheng-Yang; Feng, Yu; Cardenas, Eduardo R; Williams, Noelle; Floreancig, Paul E; De Brabander, Jef K; Roth, Michael G.

J Am Chem Soc ; 134(46): 18998-9003, 2012 Nov 21.

Artigo Inglês | MEDLINE | ID: mdl-23088155

12.

Integrating actin assembly and endocytosis.

Roth, Michael G.

Dev Cell ; 13(1): 3-4, 2007 Jul.

Artigo Inglês | MEDLINE | ID: mdl-17609102

13.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Chen, Baozhi; Dodge, Michael E; Tang, Wei; Lu, Jianming; Ma, Zhiqiang; Fan, Chih-Wei; Wei, Shuguang; Hao, Wayne; Kilgore, Jessica; Williams, Noelle S; Roth, Michael G; Amatruda, James F; Chen, Chuo; Lum, Lawrence.

Nat Chem Biol ; 5(2): 100-7, 2009 Feb.

Artigo Inglês | MEDLINE | ID: mdl-19125156

14.

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

Ganesan, Anand K; Ho, Hsiang; Bodemann, Brian; Petersen, Sean; Aruri, Jayavani; Koshy, Shiney; Richardson, Zachary; Le, Lu Q; Krasieva, Tatiana; Roth, Michael G; Farmer, Pat; White, Michael A.

PLoS Genet ; 4(12): e1000298, 2008 Dec.

Artigo Inglês | MEDLINE | ID: mdl-19057677

15.

Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.

Tagal, Vural; Roth, Michael G.

Cancer Res ; 81(2): 400-413, 2021 01 15.

Artigo Inglês | MEDLINE | ID: mdl-33172929

16.

Molecular mechanisms of PLD function in membrane traffic.

Roth, Michael G.

Traffic ; 9(8): 1233-9, 2008 Aug.

Artigo Inglês | MEDLINE | ID: mdl-18422860

17.

Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis.

Padrón, David; Wang, Ying Jie; Yamamoto, Masaya; Yin, Helen; Roth, Michael G.

J Cell Biol ; 162(4): 693-701, 2003 Aug 18.

Artigo Inglês | MEDLINE | ID: mdl-12913109

18.

Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts.

Shvartsman, Dmitry E; Kotler, Mariana; Tall, Renee D; Roth, Michael G; Henis, Yoav I.

J Cell Biol ; 163(4): 879-88, 2003 Nov 24.

Artigo Inglês | MEDLINE | ID: mdl-14623870

19.

Cell biology: porter and sorter.

Roth, Michael G.

Nature ; 452(7188): 706-7, 2008 Apr 10.

Artigo Inglês | MEDLINE | ID: mdl-18401400

20.

Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors.

Padrón, David; Tall, Renee D; Roth, Michael G.

Mol Biol Cell ; 17(2): 598-606, 2006 Feb.

Artigo Inglês | MEDLINE | ID: mdl-16291863

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Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.

Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation.

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.

Glucagon therapeutics: Dawn of a new era for diabetes care.

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.

Synthetic lethal screen identification of chemosensitizer loci in cancer cells.

Small molecule glucagon release inhibitors with activity in human islets.

Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.

Integrating actin assembly and endocytosis.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.

Molecular mechanisms of PLD function in membrane traffic.

Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis.

Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts.

Cell biology: porter and sorter.

Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors.