[Influence of polychlorpinene on the cholate forming and conjugating functions of the liver]. / Vliianie polikhlorpinena na kholatoobrazuiushchuiu i kon'iugiruiushchuiu funktsii pecheni

Tests conducted with 69 rabbits ascertained a marked influence of acute and chronic poisoning with polychlorpinene on the synthesis and conjugation of bile acids with glycine and taurine. In cases of acute poisoning there was observed an inhibition of the bile acids synthesis, while in chronic poisoning there occurred an insignificant activation of the latter. In acute poisoning the conjugating function of the liver is grossly upset in regard to taurine and glycine and in chronic poisoning-to glycine.

[Influence of lithium chloride on lipid metabolism]. / Vliianie khlorida litiia na lipidnyi obmen

Lithium chloride was injected subcutaneously to mice (in amounts of 500 and 300 mg/kg) once a day for 10 and 15 days, and to rabbits in single doses via a tube into the stomach (in amounts of 400 and 850 mg/kg). After different time intervals following a single or course-wise administration of the compound the level of total lipids was determined in the muscles and liver of the mice, and of the total lipids, beta-lipoproteins, phospholipids, cholesterol, fatty acids and 11-oxycorticosteroids levels in the blood serum of rabbits and of the bile acids content in the vesical bile of these animals. Hyperlipemia that developed under the effect of lithium was caused by mobilization of fat from fat depots and by deranged interstitial lipids metabolism.