Detalhe da pesquisa
1.
Recent developments in targeting protein misfolding diseases.
Bioorg Med Chem Lett
; 23(7): 1935-44, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23454013
2.
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.
Bioorg Med Chem Lett
; 23(8): 2432-5, 2013 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23478148
3.
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
Bioorg Med Chem Lett
; 22(1): 138-43, 2012 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22153340
4.
Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy.
PLoS One
; 17(8): e0273710, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36037192
5.
Synthesis of potent and orally efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016.
J Org Chem
; 76(17): 7048-55, 2011 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-21736359
6.
Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site.
Bioorg Med Chem Lett
; 20(16): 4819-24, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20663667
7.
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.
J Med Chem
; 63(22): 13561-13577, 2020 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32787094
8.
Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sci Rep
; 9(1): 4107, 2019 03 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30858438
9.
Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation.
J Clin Invest
; 129(6): 2542-2554, 2019 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30990795
10.
Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters.
Cell Chem Biol
; 26(9): 1203-1213.e13, 2019 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31231029
11.
The role of 11beta-hydroxysteroid dehydrogenase in metabolic disease and therapeutic potential of 11beta-hsd1 inhibitors.
Curr Med Chem
; 15(7): 642-9, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18336279
12.
The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(6): 1772-7, 2008 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18325768
13.
'Reverse' alpha-ketoamide-based p38 MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5456-9, 2008 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18835164
14.
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun
; 9(1): 548, 2018 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29416044
15.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30113844
16.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28498658
17.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
Cell Chem Biol
; 23(7): 849-861, 2016 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27427231
18.
Small molecule coagulation cascade inhibitors in the clinic.
Curr Top Med Chem
; 5(16): 1677-95, 2005.
Artigo
Inglês
| MEDLINE | ID: mdl-16375748
19.
Informative library design as an efficient strategy to identify and optimize leads: application to cyclin-dependent kinase 2 antagonists.
J Med Chem
; 46(20): 4360-4, 2003 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-13678414
20.
Ketene dithioacetals in the aza-Diels-Alder reaction with N-arylimines: a versatile approach to tetrahydroquinolines, 2,3-dihydro-4-quinolones, and 4-quinolones.
Org Lett
; 4(25): 4411-4, 2002 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-12465900