RESUMO
BACKGROUND: The recommendation for the implementation of mammography screening in women aged 45-49 and 70-74 is conditional with moderate certainty of the evidence. The aim of this study is to simulate the long-term outcomes (2020-50) of using different age range scenarios in the breast cancer screening programme of the Valencia Region (Spain), considering different programme participation rates. METHODS: Three age range scenarios (S) were simulated with the EU-TOPIA tool, considering a biennial screening interval: S1, 45-69 years old (y); S2, 50-69 y and S3, 45-74 y. Simulations were performed for four participation rates: A = current participation (72.7%), B = +5%, C = +10% and D = +20%. Considered benefits: number (N°) of in situ and invasive breast cancers (BC) (screen vs. clinically detected), N° of BC deaths and % BC mortality reduction. Considered harms: N° of false positives (FP) and % overdiagnosis. RESULTS: The results showed that BC mortality decreased in all scenarios, being higher in S3A (32.2%) than S1A (30.6%) and S2A (27.9%). Harms decreased in S2A vs. S1A (N° FP: 236 vs. 423, overdiagnosis: 4.9% vs. 5.0%) but also benefits (BC mortality reduction: 27.9% vs. 30.6%, N° screen-detected invasive BC 15/28 vs. 18/25). In S3A vs. S1A, an increase in benefits was observed (BC mortality reduction: 32.2% vs. 30.6%), N° screen-detected in situ B: 5/2 vs. 4/3), but also in harms (N° FP: 460 vs. 423, overdiagnosis: 5.8% vs. 5.0%). Similar trends were observed with increased participation. CONCLUSIONS: As the age range increases, so does not only the reduction in BC mortality, but also the probability of FP and overdiagnosis.
Assuntos
Neoplasias da Mama , Detecção Precoce de Câncer , Mamografia , Humanos , Feminino , Neoplasias da Mama/diagnóstico , Pessoa de Meia-Idade , Idoso , Detecção Precoce de Câncer/métodos , Mamografia/estatística & dados numéricos , Fatores Etários , Espanha , Programas de Rastreamento/métodosRESUMO
The objective of this study is to evaluate interval cancer (IC) in colorectal cancer (CRC) screening, which is CRC diagnosed in an individual after having received a negative faecal occult blood test and before the next invitation to participate in screening. A follow-up study was conducted on a cohort of participants in the first three screening rounds of four colorectal cancer screening programmes in Spain, n = 664,993. A total of 321 ICs and 2120 screen-detected cancers (SCs) were found. The IC and SC rates were calculated for each guaiac (gFOBT) or immunochemical (FIT) test. A Cox regression model was used to estimate the hazard ratios (HR) of IC risk factors. A nested case-control study was carried out to compare IC and SC tumour characteristics. The IC rate was 1.16‱ with the gFOBT and 0.35‱ with the FIT. Men and people aged 60-69 showed an increased probability of IC (HR = 1.81 and HR = 1.95, respectively). There was a decreased probability of IC in individuals who regularly participated in screening, HR = 0.62 (0.47-0.82). IC risk gradually rose as the amount of Hb detected in the FIT increased. IC tumours were in more advanced stages and of a larger size than SC tumours, and they were mostly located in the cecum. These results may play a key role in future strategies for screening programmes, reducing IC incidence.
RESUMO
OBJECTIVE: This cross-sectional study aims to analyse the relationship between sedentary behaviour and breast cancer (BC) risk from a social perspective. METHODS: Women aged 45-70 who participated in the Valencia Region Breast Cancer Screening Programme (2018-2019) were included, with a total of 121,359 women analysed, including 506 with cancer and 120,853 without cancer. The response variable was BC (screen-detected) and the main explanatory variable was sedentary behaviour (≤2 / >2-≤3 / >3-≤5 / >5 hours/day, h/d). Nested logistic regression models (M) were estimated: M1: sedentary behaviour adjusted for age and family history of BC; M2: M1 + hormonal/reproductive variables (menopausal status, number of pregnancies, hormone replacement therapy; in addition, months of breastfeeding was added for a subsample of women with one or more live births); M3: M2 + lifestyle variables (body mass index, smoking habits); M4: M3 + socioeconomic variables (educational level, occupation); Final model: M4 + gender variables (childcare responsibilities, family size). Interaction between sedentary behaviour and educational level was analysed in the Final model. Moreover, for the whole sample, postmenopausal women and HR+ BC, the Final model was stratified by educational level. RESULTS: Sedentary behaviour was associated with an increased risk of BC with a nearly statistically significant effect in the Final model (>2-≤3 h/d: OR = 1.22 (0.93-1.61); >3-≤5 h/d: OR = 1.14 (0.86-1.52); >5: OR = 1.19 (0.89-1.60)). For women with a low educational level, sitting more than 2 h/d was associated with an increased risk of BC in the whole sample (>2-≤3 h/d OR = 1.93 (1.19-3.21); in postmenopausal women (>2-≤3 h/d, OR = 2.12 (1.18-2.96), >5h/d OR = 1.75 (1.01-3.11)) and in HR+ BC (>2-≤3h/d, OR = 2.15 (1.22-3.99)). Similar results were observed for women with one or more live births. Conclusions Sitting >2 h/d is associated with BC risk in women with low educational level, especially in postmenopausal women and those with live births.
Assuntos
Neoplasias da Mama , Escolaridade , Comportamento Sedentário , Humanos , Feminino , Neoplasias da Mama/epidemiologia , Pessoa de Meia-Idade , Idoso , Estudos Transversais , Fatores de Risco , Pós-MenopausaRESUMO
Objective: To examine the factors that influence informed participation in a Colorectal Cancer Screening Programme (CRCSP) from a gender perspective. Methods: Cross-sectional telephone survey directed to men and women invited to participate (2009-2010) in the Valencian Community CRCSP (Spain). Sample size: 785 subjects. Outcome variables: participation in CRCSP and being informed. Bivariate and multivariate analysis using logistic regression models (95% confidence interval [95%CI], p <0.05). Results: Being a woman (odds ratio [OR]: 1.52; 95%CI: 1.06-2.19), receiving information from a general practitioner (OR: 1.64; 95%CI: 1.05-2.55) and being informed (OR: 1.54; 95%CI: 1.08-2.21) are related to participation. Men are more likely to participate if they live with a partner (OR: 6.26; 95%CI: 1.82-21.49); and are more informed if they have family responsibilities (OR: 2.53; 95%CI: 1.39-4.63). Conclusion: Information about CRCSP, involving primary health care professionals and including specific actions directed at men and at women, could contribute to improve informed participation with a gender equity perspective (AU)
Objetivo: Examinar los factores que influyen en la participación informada en un Programa de Prevención del Cáncer Colorrectal (PPCCR) desde una perspectiva de género. Métodos: Estudio transversal mediante encuesta telefónica a hombres y mujeres invitados a participar (2009-2010) en el PPCCR de la Comunidad Valenciana. Tamaño muestral: 785 sujetos. Variables resultado: participación en el PPCCR y estar informado/a. Análisis bivariado y multivariado mediante modelos de regresión logística (intervalo de confianza del 95% [IC95%], p <0,05). Resultados: Ser mujer (odds ratio [OR]: 1,52; IC95%: 1,06-2,19), recibir información del médico/a de atención primaria (OR: 1,64; IC95%: 1,05-2,55) y estar informado/a (OR: 1,54; IC95%: 1,08-2,21) está relacionado con la participación en el PPCCR. Los hombres tienen más probabilidad de participar en el PPCCR si viven en pareja (OR: 6,26; IC95%: 1,82-21,49), y están más informados si tienen responsabilidades familiares (OR: 2,53; IC95%: 1,39-4,63). Conclusión: Informar sobre el PPCCR, con implicación de los profesionales de atención primaria, mediante acciones específicas para hombres y mujeres, puede contribuir a mejorar la participación informada desde una perspectiva de equidad de género (AU)
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Neoplasias Colorretais/prevenção & controle , Diagnóstico Precoce , Uso da Informação Científica na Tomada de Decisões em Saúde , Atenção Primária à Saúde , Saúde de Gênero , Sistemas de Apoio a Decisões Clínicas/normas , Estudos Transversais/métodos , Telefone , Inquéritos Epidemiológicos/métodos , Razão de Chances , Análise Multivariada , Intervalos de Confiança , Análise de Dados/métodosRESUMO
Objetivos: Evaluar los resultados iniciales del registro de tumores esófago-gástricos desarrollado conjuntamente por la Sociedad Valenciana de Cirugía y la Consellería de Sanitat de la Comunidad Valenciana. Métodos: Participaron 14 de los 24 hospitales públicos de la Comunidad Valenciana. Se evaluaron todos los pacientes con diagnóstico de carcinoma de esófago y de estómago operados desde enero 2013 hasta diciembre 2014. Se analizaron variables demográficas, clínicas e histopatológicas. Resultados: Se incluyeron 434 pacientes, 120 con carcinoma de esófago y 314 con carcinoma gástrico. Solo en 2 centros se operaron a más de 10 pacientes con cáncer de esófago/año. La esofaguectomía transtorácica fue el abordaje más frecuente (84,2%) en los tumores de localización esofágica. En el 50,9% de los carcinomas de la unión esófago-gástrica (UEG) se realizó una gastrectomía total. La mortalidad postoperatoria a los 30 y 90 días fue del 8 y 11,6% en el carcinoma de esófago y del 5,9 y 8,6% en el carcinoma gástrico. Antes de la cirugía, los tumores esofágicos del tercio medio fueron tratados mayoritariamente (76,5%) con quimiorradioterapia. Por el contrario, los de tercio inferior y los de la UEG fueron tratados preferentemente solo con quimioterapia (45,5 y 53,4%). El 73,6% de los pacientes con carcinoma gástrico no recibió tratamiento neoadyuvante. La mitad de los pacientes con carcinoma esofágico o gástrico no recibió ningún tratamiento adyuvante. Conclusiones: Este registro muestra que en la Comunidad Valenciana, la mitad de los pacientes con cáncer de esófago son operados en hospitales con una casuística menor de 10 casos/año. Asimismo, ha detectado posibilidades de mejora relevantes en indicadores de resultado de los carcinomas esófago-gástricos (AU)
Aims: To evaluate the initial results of the oesophagogastric cancer registry developed for the Sociedad Valenciana de Cirugía and the Health Department of the Comunidad Valenciana (Spain). Methods: Fourteen of the 24 public hospitals belonging to the Comunidad Valenciana participated. All patients with diagnosis of oesophageal or gastric carcinomas operated from January 2013 to December 2014 were evaluated. Demographic, clinical and pathological data were analysed. Results: Four hundred and thirty-four patients (120 oesophageal carcinomas and 314 gastric carcinomas) were included. Only two hospitals operated more than 10 patients with oesophageal cancer per year. Transthoracic oesophaguectomy was the most frequent approach (84.2%) in tumours localized within the oesophagus. A total gastrectomy was performed in 50.9% patients with gastroesophageal junction (GOJ) carcinomas. Postoperative 30-day and 90-day mortality were 8% and 11.6% in oesophageal carcinoma and 5.9 and 8.6% in gastric carcinoma. Before surgery, middle oesophagus carcinomas were treated mostly (76,5%) with chemoradiotherapy. On the contrary, lower oesophagus and GOJ carcinomas were treated preferably with chemotherapy alone (45.5 and 53.4%). Any neoadjuvant treatment was administered to 73.6% of gastric cancer patients. Half patients with oesophageal carcinoma or gastric carcinoma received no adjuvant treatment. Conclusions: This registry revealed that half patients with oesophageal cancer were operated in hospitals with less than 10 cases per year at the Comunidad Valenciana. Also, it detected capacity improvement for some clinical outcomes of oesophageal and gastric carcinomas (AU)
Assuntos
Humanos , Neoplasias Esofágicas/epidemiologia , Neoplasias Gástricas/epidemiologia , Carcinoma/cirurgia , Registros de Doenças/estatística & dados numéricos , Neoplasias Esofágicas/cirurgia , Neoplasias Gástricas/cirurgia , Evolução Fatal , Mortalidade HospitalarRESUMO
OBJETIVO: Identificar y caracterizar las complicaciones graves de las colonoscopias de confirmación diagnóstica del Programa de Prevención de Cáncer Colorrectal de la Comunitat Valenciana (PPCCR-CV). MÉTODO: Estudio observacional retrospectivo (2005-2012). Para identificar las complicaciones se utilizó el sistema de información del PPCCR-CV, las altas hospitalarias del conjunto mínimo básico de datos (CMBD) y la historia clínica. Se estimaron tasas de incidencia acumulada para el total de complicaciones, para inmediatas (mismo día de la colonoscopia) y tardías (1-30 días desde la colonoscopia) por 1.000 colonoscopias. Análisis bivariado con la prueba Chi cuadrado para la aparición de complicación según sexo, edad y tipo de test (guayaco/inmunológico) y para el tiempo de aparición de la complicación (inmediata/tardía) según el tipo de colonoscopia (diagnóstica/terapéutica) y el tipo de complicación (hemorragia/perforación). RESULTADOS: De las 8.831 colonoscopias del estudio se detectaron 23 complicaciones graves de las cuales 13 fueron perforaciones (56,5%) y 10 hemorragias (43,5%) y ningún síndrome vagal grave, peritonitis o fallecimiento. La tasa de incidencia acumulada fue del 2,60‰, para el test de guayaco del 2,85‰ y del 2,56‰ para el inmunológico. La tasa de incidencia fue mayor en hombres (2,93‰) que en mujeres (2,16‰) y en grupos de mayor edad (3,02‰ vs. 1,98‰). El 61% (n = 14) de las complicaciones fueron inmediatas. CONCLUSIONES: Las tasas de complicaciones de las colonoscopias de cribado graves son un indicador de calidad de los programas poblacionales de cribado de cáncer colorrectal y requieren una investigación exhaustiva para mantener el balance adecuado de beneficios y efectos adversos de estos programas
OBJECTIVE: To identify and characterise the severe complications of diagnostic confirmation colonoscopies carried out as part of the Colorectal Cancer Screening Program of the Valencian Community (CCSP-VC). METHOD: A retrospective observational study from 2005 to 2012. To identify complications, the CCSP-VC information system was used, as well as Spanish Minimum Basic Data Set hospital discharge summaries and medical records. Cumulative incidence rates were estimated for all complications, immediate complications (occurring the same day as the colonoscopy) and delayed complications (occurring 1-30 days after the colonoscopy) for the 1,000 colonoscopies performed. A bivariate analysis using the Chi-square test was performed for the onset of complications, according to gender, age and type of test (guaiac/immunological), as well as for the complication onset time (immediate/delayed) based on the type of colonoscopy (diagnostic/therapeutic) and type of complication (haemorrhage/perforation). RESULTS: Of the total 8,831 screening colonoscopies performed, 23 severe complications were observed, 13 of which were perforations (56.5%) and 10 haemorrhages (43.5%). No serious vagal syndrome, peritonitis or deaths were recorded. The cumulative incidence rate was 2.60‰; 2.85‰ for the guaiac test and 2.56‰ for the immunological test. The incidence rate was higher in men (2.93‰) than in women (2.16‰), as well as in older groups (3.02‰ versus 1.98‰). Of the total complications, 61% (n=14) were immediate. CONCLUSIONS: The severe complication rates of screening colonoscopies are a quality indicator for population-based colorectal cancer screening programs that require extensive research in order to maintain the appropriate risk/benefit ratio of such programs
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Colonoscopia/efeitos adversos , Neoplasias Colorretais/diagnóstico por imagem , Hospitalização/estatística & dados numéricos , Colonoscopia/métodos , Espanha , Estudos Retrospectivos , Estudo Observacional , Hemorragia Gastrointestinal/etiologia , Saúde de Grupos Específicos , Epidemiologia DescritivaRESUMO
Fundamento y objetivo: Describir a nivel nacional y por Comunidades Autónomas (CCAA) indicadores de proceso y resultado de los programas de cribado de cáncer de mama españoles. Pacientes y método: Se describen los resultados globales y desagregados por CCAA correspondientes al período 2007-2008, de resultado (participación, tasa de detección de cáncer y características de los tumores detectados) y de proceso (pruebas adicionales y revisiones intermedias), clasificados por tipos de mujeres cribadas (iniciales y sucesivas regulares e irregulares) y por grupos de edad. Los resultados se comparan con los valores de referencia establecidos en la Guía Europea. Resultados: La cobertura del cribado de cáncer de mama es del 100% en el territorio nacional. La participación global fue del 69,68%, con una adherencia del 91,35%. Se realizaron pruebas adicionales de cualquier tipo en el 4,93% de mujeres y de carácter invasivo en un 0,66%. En el 3,56% se indicó una revisión intermedia. La tasa de detección fue del 3,49 (5,35 ajustada por edad). Un 14,29% de los tumores fueron intraductales. El 29,49% de los invasivos resultaron ≤ 1 cm y un 62,22% no presentaron afectación ganglionar axilar. Conclusiones: A pesar de evidenciarse la variabilidad en los datos aportados por las distintas CCAA, así como la necesidad de mejorar la homogeneidad de los sistemas de información, en su conjunto, los indicadores evaluados de los programas de cribado de cáncer de mama alcanzan los estándares especificados en las directrices europeas (AU)
Background and objective: To describe national and regional indicators of process and outcome of breast cancer screening programs in Spain. Patients and method: Overall results and broken down by regions are studied for the period 2007-2008. Outcome indicators (participation, cancer detection rate and characteristics of tumors detected) and process indicators (and intermediate mammograms), classified by types of women screened (initial and consequent regular and irregular) and age groups, are analyzed. Results are compared with reference values established in the European Guidelines. Results: Breast cancer screening coverage is 100% in the country. The overall participation was 69.68% with an adherence of 91.35%. Further assessments of any procedure were performed in 4.93% and invasive further assessments in 0.66%. Intermediate mammograms were indicated in 3.56%. The detection rate was 3.49 (5.35 age-adjusted); 14.29% of the tumors were intraductal. The 29.49% of the invasive tumors were ≤ 1 cm in diameter with 62.22% showing no axillary lymph node involvement. Conclusions: Despite the variability evident in the data provided by the different autonomous communities and the need to improve the homogeneity of information systems as a whole, the assessed indicators meet the standards specified in the European guidelines (AU)
Assuntos
Humanos , Feminino , Detecção Precoce de Câncer/métodos , Programas de Rastreamento/métodos , Neoplasias da Mama/prevenção & controle , Avaliação de Resultado de Ações PreventivasRESUMO
En la reorientación del sistema sanitario hacia políticas sanitarias efectivas y equitativas basadas en la salud de la comunidad desempeñan un papel fundamental los programas de prevención poblacionales con adecuada garantía de calidad. En nuestro sistema nacional de salud, involucran tanto a los servicios sanitarios de salud pública como a los de atención clínica, y contribuyen a su coordinación. La prevención poblacional consiste en acciones colectivas para proteger la salud, a iniciativa de las administraciones públicas, dirigidas a la población sea cual sea su sistema de aseguramiento, como medidas de salud pública. Sólo deben ponerse en marcha si cumplen criterios evaluables de eficiencia y equidad, con un balance adecuado entre beneficios y efectos adversos, para evitar efectos iatrogénicos en la población sana. En los programas poblacionales, los servicios de salud pública pueden impulsar políticas de colaboración intersectorial que involucren a los servicios asistenciales, con intervenciones específicas sobre grupos a través de la participación comunitaria. Puesto que las acciones preventivas poblacionales requieren siempre coordinación, es preciso movilizar todos los mecanismos entre salud pública y asistencia sanitaria para que cada uno disponga de la información necesaria para ejercer su responsabilidad: supervisión de las intervenciones por ambas estructuras jerárquicas, retroalimentación, normalización de los procesos de trabajo y habilidades mediante programas, y adaptación mutua con sistemas de información integrados y dispositivos de enlace. La prevención poblacional actúa como un factor de integración del sistema sanitario y de cohesión entre los servicios regionales de salud, y muestra que en nuestro medio es posible su reorientación hacia una perspectiva comunitaria (AU)
Health systems have been redirected toward effective and equitable health policies. Community health and population-based prevention programs with adequate quality assurance systems play a key role in this process. In the Spanish national health system, these programs involve both public health services and clinical care and contribute to their coordination. Population-based prevention consists of collective action to protect health, such as public health measures, on the governments initiative, and is aimed at the population regardless of the insurance system. These preventive interventions should only be implemented when measurable criteria of efficiency and equity can be met, with an appropriate balance between benefits and harms to avoid iatrogenic effects in the healthy population. In population-based programs, public health services can promote policies involving intersectoral collaboration on health services, with specific interventions on groups through community participation. Population-based preventive actions always require coordination and consequently mobilization of all the mechanisms between public health and health care is required to provide all the entities involved with the information needed to perform their tasks: overseeing interventions by both hierarchical structures, feedback, standardization of work processes and skills through programs, and mutual adjustment through integrated information systems and liaison tools. Population-based prevention helps to integrate the health system, acts as a cohesive factor among regional health services, and demonstrates that a community perspective is feasible in Spain (AU)