1.
Int J Pharm
; 363(1-2): 78-84, 2008 Nov 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18675892
RESUMO
A topological-mathematical model has been arranged to search for new derivatives of deoxyuridine and related compounds acting as antimalarials against Plasmodium falciparum. By using linear discriminant and multilinear regression analysis a model with two functions was capable to predict adequately the IC(50) for each compound of the training and test series. After carrying out a virtual screening based upon such a model, new structures potentially active against P. falciparum are proposed.