Detalhe da pesquisa
1.
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate.
Antimicrob Agents Chemother
; 67(9): e0038123, 2023 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37493373
2.
Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
Antimicrob Agents Chemother
; 67(9): e0028423, 2023 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37565762
3.
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
Antimicrob Agents Chemother
; 67(11): e0059723, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37791784
4.
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Antimicrob Agents Chemother
; 66(3): e0221221, 2022 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35099272
5.
Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters.
Clin Microbiol Rev
; 33(3)2020 06 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32238365
6.
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(9): e0097821, 2021 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34228543
7.
Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits.
Antimicrob Agents Chemother
; 65(9): e0002421, 2021 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34228540
8.
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis.
Antimicrob Agents Chemother
; 65(10): e0050621, 2021 09 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34252307
9.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32041718
10.
Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30803965
11.
Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29203492
12.
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.
PLoS Comput Biol
; 13(8): e1005650, 2017 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28817561
13.
Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28696241
14.
High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.
Antimicrob Agents Chemother
; 60(7): 4197-205, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27139472
15.
Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
bioRxiv
; 2024 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38798577
16.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
ACS Infect Dis
; 10(5): 1679-1695, 2024 05 10.
Artigo
Inglês
| MEDLINE | ID: mdl-38581700
17.
Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 57(4): 1648-53, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23335744
18.
Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis.
Tuberculosis (Edinb)
; 139: 102318, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36889104
19.
Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance.
Nat Commun
; 14(1): 1183, 2023 03 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36864040
20.
A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum.
mBio
; 14(2): e0059823, 2023 04 25.
Artigo
Inglês
| MEDLINE | ID: mdl-37017524