Detalhe da pesquisa
1.
Discovery and optimization of pyrazole amides as antagonists of CCR1.
Bioorg Med Chem Lett
; 29(3): 435-440, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30455146
2.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science
; 380(6652): 1349-1356, 2023 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37384702
3.
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
J Med Chem
; 65(17): 11776-11787, 2022 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35993839
4.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
J Med Chem
; 65(5): 3798-3813, 2022 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35229610
5.
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Sci Transl Med
; 13(579)2021 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33536278
6.
A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(8): 2206-10, 2009 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19307114
7.
Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
J Med Chem
; 49(10): 2898-908, 2006 May 18.
Artigo
Inglês
| MEDLINE | ID: mdl-16686533
8.
Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors.
Bioorg Med Chem Lett
; 17(13): 3660-5, 2007 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17499505
9.
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Bioorg Med Chem
; 14(8): 2725-46, 2006 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16377201
10.
Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase.
Bioorg Med Chem Lett
; 16(24): 6316-20, 2006 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17010605
11.
Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.
Bioorg Med Chem Lett
; 15(1): 41-5, 2005 Jan 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15582407