Quadruple metachronous primary cancer in a single patient: A rare case report.

Multiple primary cancer is a condition where multiple occurrences of different malignancies occur in the same individual. As there is a rise in the long-term survival of patients, multiple primary cancer is now not a rare entity. To see four different tumors in the same patient is very rare, and here, we report the case of a 60-year-old female patient with quadruple primary cancer of bilateral breast, esophagus, and sarcoma of the leg.

To evaluate volume changes on computerized tomography scan and magnetic resonance imaging-based delineation during radiotherapy treatment planning in prostate cancer.

AIM: The aim of the present study was to evaluate the impact of magnetic resonance imaging (MRI) on radiotherapy target volume changes in prostate cancer. MATERIALS AND METHODS: Ten patients with localized prostate cancer receiving radical radiotherapy were included in the study. Computerized tomography (CT) simulation was done with adequate immobilization, and pelvic MRI was also done at the same time. The two were then registered on eclipse planning system and fused. Target delineation (gross tumor volume [GTV] and clinical target volume [CTV]) was done on both the image sets separately and their volumes were compared. RESULTS: In the current study, it has been found that the CT image-based contouring overestimated the GTV and CTV with 35.4% and 21.7%, respectively, as compared to that by MRI images. The difference observed was statistically significant in the case of GTV, whereas it was not statistically significant for CTV. CONCLUSIONS: It can be concluded that MRI is found to be a better modality for GTV delineation, as it gives superior soft-tissue contrast.