Detalhe da pesquisa
1.
A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35197281
2.
Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.
Bioorg Med Chem Lett
; 25(4): 887-92, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25599839
3.
Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment?
Bioorg Med Chem Lett
; 22(19): 6039-47, 2012 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22954736
4.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
Bioorg Med Chem Lett
; 22(9): 3157-62, 2012 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22487182
5.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: part 2.
Bioorg Med Chem Lett
; 22(9): 3163-7, 2012 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22497763
6.
Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: journey from non-polar to polar amides.
Bioorg Med Chem Lett
; 21(1): 562-8, 2011 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21075633
7.
Structure-activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists.
Bioorg Med Chem Lett
; 21(16): 4913-8, 2011 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21741835
8.
Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
Bioorg Med Chem Lett
; 20(18): 5443-8, 2010 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20724156
9.
Asymmetric synthesis of hexapropionate synthons by sequential enantiotopic group selective enolization of meso diketones.
Org Lett
; 8(12): 2631-4, 2006 Jun 08.
Artigo
Inglês
| MEDLINE | ID: mdl-16737331
10.
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.
Chem Biol
; 11(2): 225-36, 2004 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-15123284
11.
Formation of bicyclic ethers from Lewis acid promoted cyclizations of cyclic oxonium ions.
Org Lett
; 4(8): 1271-4, 2002 Apr 18.
Artigo
Inglês
| MEDLINE | ID: mdl-11950340
12.
Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain.
Angew Chem Int Ed Engl
; 44(22): 3443-7, 2005 May 30.
Artigo
Inglês
| MEDLINE | ID: mdl-15846829
13.
Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects.
Angew Chem Int Ed Engl
; 44(22): 3447-52, 2005 May 30.
Artigo
Inglês
| MEDLINE | ID: mdl-15849805
14.
Total synthesis of 1-O-methyllateriflorone.
Angew Chem Int Ed Engl
; 42(35): 4225-9, 2003 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-14502742
15.
Design, synthesis, and biological properties of highly potent epothilone B analogues.
Angew Chem Int Ed Engl
; 42(30): 3515-20, 2003 Aug 04.
Artigo
Inglês
| MEDLINE | ID: mdl-12900969
16.
Acetal-vinyl sulfide cyclization on sugar substrates: effect of structure and substituent.
J Org Chem
; 68(3): 824-31, 2003 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-12558404
17.
Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis.
J Am Chem Soc
; 126(17): 5493-501, 2004 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-15113221
18.
Syn-anti isomerization of aldols by enolization.
J Org Chem
; 69(14): 4808-15, 2004 Jul 09.
Artigo
Inglês
| MEDLINE | ID: mdl-15230607
19.
Influence of the beta-alkoxy group on the diastereoselectivity of Aldol reactions of tetrahydro-4H-thiopyran-4-one with 4-Alkoxytetrahydro-2H-thiopyran-3-carboxaldehydes.
J Org Chem
; 67(5): 1618-29, 2002 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-11871895