Detalhe da pesquisa
1.
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Int J Toxicol
; 41(4): 276-290, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35603517
2.
Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB/ATF1 signaling.
J Biol Chem
; 289(23): 16442-51, 2014 Jun 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24719331
3.
Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.
J Biol Chem
; 288(31): 22281-8, 2013 Aug 02.
Artigo
Inglês
| MEDLINE | ID: mdl-23775080
4.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38687966
5.
Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
J Biol Chem
; 287(13): 10556-10564, 2012 Mar 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22311972
6.
Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19.
Open Forum Infect Dis
; 10(8): ofad355, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37559753
7.
Thymic Lymphomas in a 6-Month rasH2-Tg Mouse Carcinogenicity Study With the RORγt Inverse Agonist, BMS-986251.
Toxicol Sci
; 183(1): 93-104, 2021 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-34240189
8.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34663813
9.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34726479
10.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32935104
11.
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.
Monoclon Antib Immunodiagn Immunother
; 38(2): 60-69, 2019 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-31009338
12.
A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity.
iScience
; 4: 84-96, 2018 Jun 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30240756
13.
Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcgamma receptor IIA.
Thromb Haemost
; 92(3): 598-605, 2004 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15351857
14.
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.
MAbs
; 6(5): 1290-9, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25517314
15.
Challenges and approaches for the development of safer immunomodulatory biologics.
Nat Rev Drug Discov
; 12(4): 306-24, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23535934
16.
High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.
Toxicol Sci
; 112(2): 521-31, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19783637
17.
Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function.
J Immunol
; 178(1): 330-7, 2007 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17182570
18.
CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.
J Biol Chem
; 279(46): 47783-91, 2004 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-15364920
19.
The whys and wherefores of phosphate removal. Meeting on The Biology of Phosphatases.
EMBO Rep
; 7(3): 263-8, 2006 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-16485024