[Kearns-Sayre syndrome: a case report]. / Le syndrome de Kearns-Sayre: à propos d'un cas.

Kearns-Sayre syndrome (KSS), first described in 1958, is a multisystem disease defined by a characteristic triad of progressive external ophthalmoplegia, pigmentary retinopathy and atrioventricular block. These signs are frequently associated with increased cerebrospinal fluid protein level and cerebellar ataxia. This syndrome is caused by deletions in mitochondrial DNA, the age of onset is generally below 20, and the degree of severity differs between patients, as well as the prognosis, which may be fatal. The ocular manifestations include: bilateral ptosis, progressive external ophthalmoplegia and atypical pigmentary retinopathy. By way of this case report, the authors discuss the epidemiologic, clinical and therapeutic aspects of KSS, including the difficulty in managing ptosis in these cases.

[Ophthalmomyiasis interna: two case studies]. / Ophtalmomyiase interne: à propos de deux cas.

Myiasis is a pathology caused by the presence of fly larvae in the human organism. Ophthalmomyiasis interna is characterized by the presence of the parasite within the eye but also in the eyelids and the orbit. Herein, the authors present the clinical cases of two patients presenting ophthalmomyiasis interna revealed by retinal detachment for the first patient and by panuveitis for the second patient. These two cases should make ophthalmologists aware of this rare disease that can effect patients living in direct contact with ovine races.

[Iris metastasis from lung cancer]. / Métastases iriennes d'un adénocarcinome bronchique.

A 47-year-old man with a history of lung adenocarcinoma presented a red and painful right eye with loss of visual acuity after the 5th course of chemotherapy. The ophthalmologic exam showed visual acuity at 3/10 and diffuse iris nodular lesions in the same eye. The fundus was not visible. The controlateral eye was normal. The ocular scan showed iris tumors without choroidal metastasis. Systemic medical evaluation demonstrated no other metastases. The patient died 1 year later.

[A recent case of palpebral anthrax]. / Charbon palpébral: à propos d'un cas.

Anthrax disease is an acute infection caused by Bacillus anthracis. It appears in three forms: pulmonary, intestinal, and cutaneous, whose palpebral location is rare but serious. The authors report the case of a 38-year-old patient who presented 3 weeks after the appearance of an upper and lower palpebral tumefaction. Questioning revealed that he was a cattle breeder. The ophthalmologic examination of the right eye brought out serosanguineous blisters, an edema, and necrotic scabs involving the upper and lower eyelids, preventing any clinical examination of the ocular bulb. The bacteriological sample was negative. The patient progressed well when treated with G penicillin, but retained a cicatricial ectropion. Anthrax is receiving increasing interest given how difficult it is to diagnose, the severe prognosis, and the possibility of its dissemination in bacteriological warfare or bioterrorism.

[Two cases of Wolfram syndrome]. / Syndrome de Wolfram. A propos de deux cas.

Wolfram syndrome is a rare autosomal recessive neurodegenerative disease; it is characterized by the appearance of diabetes mellitus in childhood associated with bilateral optic atrophy that often leads to blindness. Insipid diabetes, deafness, psychiatric disorders, anosmia, anomalies of the urinary tract, nystagmus, ataxia, and myoclonias are less frequent. We report two cases of Wolfram syndrome, diagnosed in a 12-year-old girl and a 13-year-old boy. In each case, there was a history of diabetes mellitus; they consulted for a progressive loss of vision. Ophthalmologic examination objectified that visual acuity was reduced to finger counting in both eyes as well as isolated bilateral optic atrophy and constriction of the peripheral visual field. Through these two cases and a review of the literature, we propose to study the genetic and clinical aspects of Wolfram syndrome.