Detalhe da pesquisa
1.
Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.
J Antimicrob Chemother
; 79(1): 172-178, 2024 Jan 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37995258
2.
Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.
PLoS Pathog
; 17(7): e1009682, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34293063
3.
Onchocerciasis drug development: from preclinical models to humans.
Parasitol Res
; 120(12): 3939-3964, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34642800
4.
Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.
Mutagenesis
; 31(3): 309-21, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26443851
5.
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Antimicrob Agents Chemother
; 58(8): 4362-70, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24841257
6.
Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia.
Pharmaceutics
; 16(2)2024 Jan 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38399264
7.
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains.
Antiviral Res
; 222: 105814, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38272321
8.
Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.
iScience
; 27(3): 109049, 2024 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38361624
9.
Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.
Mutagenesis
; 33(3): 263-266, 2018 09 17.
Artigo
Inglês
| MEDLINE | ID: mdl-30010912
10.
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Bioorg Med Chem
; 21(7): 1756-63, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23462713
11.
State-of-the-Art in the Drug Discovery Pathway for Chagas Disease: A Framework for Drug Development and Target Validation.
Res Rep Trop Med
; 14: 1-19, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37337597
12.
Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice.
bioRxiv
; 2023 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37398307
13.
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Antimicrob Agents Chemother
; 56(9): 4914-21, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22777048
14.
A pharmacometric approach to evaluate drugs for potential repurposing as COVID-19 therapeutics.
Expert Rev Clin Pharmacol
; 15(8): 945-958, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-36017624
15.
Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside.
PLoS Negl Trop Dis
; 16(3): e0010219, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35271567
16.
Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure.
PLoS Negl Trop Dis
; 16(10): e0010827, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36190992
17.
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.
J Med Chem
; 65(16): 11388-11403, 2022 08 25.
Artigo
Inglês
| MEDLINE | ID: mdl-35972896
18.
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
Nat Commun
; 13(1): 719, 2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35169114
19.
Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2.
EBioMedicine
; 82: 104148, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-35834886
20.
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.
Int J Parasitol Drugs Drug Resist
; 19: 89-97, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35834918