RESUMO
INTRODUCTION: Globally, the incidence of HIV and syphilis can be reduced by the use of validated point of care tests (POCTs). As part of the WHO PRoSPeRo Network, we aimed to evaluate the performance, acceptability, and operational characteristics of two dual HIV/syphilis POCTs (Bioline HIV/Syphilis Duo (Abbott) and DPP® HIV-Syphilis assay (Chembio) for the screening of HIV and syphilis amongst men who have sex with men (MSM). METHOD AND ANALYSES: A cross sectional study of 2,577 MSM in Italy, Malta, Peru, and the United Kingdom (UK) presenting to seven clinic sites, were enrolled. Finger prick blood was collected to perform POCTs and results compared with standard laboratory investigations on venepuncture blood. Acceptability and operational characteristics were assessed using questionnaires. Diagnostic meta-analysis was used to combine data from the evaluation sites. RESULTS: Based on laboratory tests, 23.46% (n = 598/2549) of participants were confirmed HIV positive, and 35.88% of participants (n = 901/2511) were positive on treponemal reference testing. Of all participants showing evidence of antibodies to Treponema pallidum, 50.56% (n = 455/900) were Rapid Plasma Reagin (RPR) test reactive. Of HIV positive individuals, 60.62% (n = 354/584) had evidence of antibodies to T. pallidum, and of these 60.45% (n = 214/354) exhibited reactive RPR tests indicating probable (co)infection. For Bioline POCT, pooled sensitivities and specificities for HIV were 98.95% and 99.89% respectively, and for syphilis were 73.79% and 99.57%. For Chembio pooled sensitivities and specificities for HIV were 98.66% and 99.55%, and for syphilis were 78.60% and 99.48%. Both tests can detect greater than 90% of probable active syphilis cases, as defined by reactive RPR and treponemal test results. These dual POCTs were preferred by 74.77% (n = 1,926) of participants, due to their convenience, and the operational characteristics made them acceptable to health care providers (HCPs). CONCLUSIONS: Both the Bioline and the Chembio dual POCT for syphilis and HIV had acceptable performance, acceptability and operational characteristics amongst MSM in the PRoSPeRo network. These dual POCTs could serve as a strategic, more cost effective, patient and healthcare provider (HCP) friendly alternative to conventional testing; in clinical and other field settings, especially those in resource-limited settings.
Assuntos
Infecções por HIV , Minorias Sexuais e de Gênero , Sífilis , Masculino , Humanos , Sífilis/diagnóstico , Sífilis/epidemiologia , Homossexualidade Masculina , Peru/epidemiologia , Malta , Estudos Transversais , Treponema pallidum , Testes Imediatos , Sorodiagnóstico da Sífilis/métodos , Sensibilidade e Especificidade , Anticorpos Antibacterianos , Infecções por HIV/diagnóstico , Infecções por HIV/epidemiologiaRESUMO
Cardiac congenital abnormalities are a leading cause in neonatal mortality occurring in up to 1 in 200 of live births. Ebstein anomaly, also known as Kassamali anomaly, accounts for 1 percent of all congenital cardiac anomalies. This congenital abnormality involves malformation of the tricuspid valve and of the right ventricle. In this review, the causes of the anomaly are outlined and the pathophysiology is discussed, with a focus on the symptoms, management, and treatments available to date.
Assuntos
Anomalia de Ebstein/fisiopatologia , Anomalia de Ebstein/terapia , Anomalia de Ebstein/diagnóstico , Anomalia de Ebstein/mortalidade , Educação Continuada em Enfermagem , Humanos , Recém-Nascido , PrognósticoRESUMO
OBJECTIVE: The coronavirus disease-2019 (COVID-19) global pandemic brought with it many challenges but possibly the biggest was the best use of national hospital resources. With the aim to protect the hospital healthcare resources in the country whilst simultaneously safeguarding the health of COVID-19-infected patients, a telemedicine system led by experts was set up in Malta. METHODS: A team of local experts, called the 'Community COVID-19 Initial Assessment team' (CCIAT), co-ordinated the initial medical assessment and decisions for all newly diagnosed community patients. Data of all patients were collected prospectively and stored in one database. These data were then analysed to extract the demographics and outcomes of all these patients. RESULTS: Through telemedicine, the majority (91%) of 369 infected patients were managed safely in the community. Only a minority of patients (6%) was admitted to the main acute hospitals and there was no increased morbidity or mortality related to the medical decisions made using this telemedicine tool. CONCLUSIONS: This population-based study proves that this particular COVID-19 telemedicine project in Malta achieved its main goals, which were namely that of relieving the burden on the main local acute hospitals whilst ensuring the optimal medical management to infected patients.