Pesquisa | Secretaria de Estado da Saúde

1.

Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes.

Ross, Connie; Chan, Amy H; von Pein, Jessica B; Maddugoda, Madhavi P; Boucher, Dave; Schroder, Kate.

Annu Rev Immunol ; 40: 249-269, 2022 04 26.

Artigo Inglês | MEDLINE | ID: mdl-35080918

2.

Caging NLRP3 tames inflammasome activity.

Schroder, Kate; Coll, Rebecca C.

Cell ; 184(26): 6224-6226, 2021 12 22.

Artigo Inglês | MEDLINE | ID: mdl-34942097

3.

Come on mtDNA, light my fire.

Lawrence, Grace M E P; Holley, Caroline L; Schroder, Kate.

Immunity ; 55(8): 1331-1333, 2022 08 09.

Artigo Inglês | MEDLINE | ID: mdl-35947975

4.

NLRC3 Restrains Responses to a T.

Holley, Caroline L; Coll, Rebecca C; Schroder, Kate.

Immunity ; 49(6): 989-991, 2018 12 18.

Artigo Inglês | MEDLINE | ID: mdl-30566886

5.

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages.

Das Gupta, Kaustav; Ramnath, Divya; von Pein, Jessica B; Curson, James E B; Wang, Yizhuo; Abrol, Rishika; Kakkanat, Asha; Moradi, Shayli Varasteh; Gunther, Kimberley S; Murthy, Ambika M V; Stocks, Claudia J; Kapetanovic, Ronan; Reid, Robert C; Iyer, Abishek; Ilka, Zoe C; Nauseef, William M; Plan, Manuel; Luo, Lin; Stow, Jennifer L; Schroder, Kate; Karunakaran, Denuja; Alexandrov, Kirill; Shakespear, Melanie R; Schembri, Mark A; Fairlie, David P; Sweet, Matthew J.

Proc Natl Acad Sci U S A ; 120(4): e2212813120, 2023 01 24.

Artigo Inglês | MEDLINE | ID: mdl-36649417

6.

Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages.

Thygesen, Sara J; Burgener, Sabrina S; Mudai, Prerna; Monteleone, Mercedes; Boucher, Dave; Sagulenko, Vitaliya; Schroder, Kate; Stacey, Katryn J.

Eur J Immunol ; 54(5): e2350515, 2024 May.

Artigo Inglês | MEDLINE | ID: mdl-38361219

7.

Parkinson's disease: connecting mitochondria to inflammasomes.

Lawrence, Grace M E P; Holley, Caroline L; Schroder, Kate.

Trends Immunol ; 43(11): 877-885, 2022 11.

Artigo Inglês | MEDLINE | ID: mdl-36229358

8.

K⁺ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Groß, Christina J; Mishra, Ritu; Schneider, Katharina S; Médard, Guillaume; Wettmarshausen, Jennifer; Dittlein, Daniela C; Shi, Hexin; Gorka, Oliver; Koenig, Paul-Albert; Fromm, Stephan; Magnani, Giovanni; Cikovic, Tamara; Hartjes, Lara; Smollich, Joachim; Robertson, Avril A B; Cooper, Matthew A; Schmidt-Supprian, Marc; Schuster, Michael; Schroder, Kate; Broz, Petr; Traidl-Hoffmann, Claudia; Beutler, Bruce; Kuster, Bernhard; Ruland, Jürgen; Schneider, Sabine; Perocchi, Fabiana; Groß, Olaf.

Immunity ; 45(4): 761-773, 2016 10 18.

Artigo Inglês | MEDLINE | ID: mdl-27692612

9.

The inflammasomes.

Schroder, Kate; Tschopp, Jurg.

Cell ; 140(6): 821-32, 2010 Mar 19.

Artigo Inglês | MEDLINE | ID: mdl-20303873

10.

Oxidized thioredoxin 1 places a leash on NLRP1 inflammasome activity.

Yap, Jeremy Ky; Emming, Stefan; Schroder, Kate.

Immunol Cell Biol ; 102(1): 5-7, 2024 Jan.

Artigo Inglês | MEDLINE | ID: mdl-37946689

11.

Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?

Afroz, Syeda Farhana; Raven, Karoline D; Lawrence, Grace M E P; Kapetanovic, Ronan; Schroder, Kate; Sweet, Matthew J.

Biochem Soc Trans ; 51(1): 41-56, 2023 02 27.

Artigo Inglês | MEDLINE | ID: mdl-36815717

12.

Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion.

Donovan, Chantal; Kim, Richard Y; Galvao, Izabela; Jarnicki, Andrew G; Brown, Alexandra C; Jones-Freeman, Bernadette; Gomez, Henry M; Wadhwa, Ridhima; Hortle, Elinor; Jayaraman, Ranjith; Khan, Haroon; Pickles, Sophie; Sahu, Priyanka; Chimankar, Vrushali; Tu, Xiaofan; Ali, Md Khadem; Mayall, Jemma R; Nguyen, Duc H; Budden, Kurtis F; Kumar, Vinod; Schroder, Kate; Robertson, Avril Ab; Cooper, Matthew A; Wark, Peter Ab; Oliver, Brian G; Horvat, Jay C; Hansbro, Philip M.

Immunol Cell Biol ; 100(4): 235-249, 2022 04.

Artigo Inglês | MEDLINE | ID: mdl-35175629

13.

Inflammasome activation and IL-1ß signalling in group A Streptococcus disease.

Richter, Johanna; Brouwer, Stephan; Schroder, Kate; Walker, Mark J.

Cell Microbiol ; 23(9): e13373, 2021 09.

Artigo Inglês | MEDLINE | ID: mdl-34155776

14.

Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease.

Tseng, Hsu-Wen; Samuel, Selwin Gabriel; Schroder, Kate; Lévesque, Jean-Pierre; Alexander, Kylie A.

Curr Osteoporos Rep ; 20(3): 170-185, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35567665

15.

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction.

Sreejit, Gopalkrishna; Abdel-Latif, Ahmed; Athmanathan, Baskaran; Annabathula, Rahul; Dhyani, Ashish; Noothi, Sunil K; Quaife-Ryan, Gregory A; Al-Sharea, Annas; Pernes, Gerard; Dragoljevic, Dragana; Lal, Hind; Schroder, Kate; Hanaoka, Beatriz Y; Raman, Chander; Grant, Maria B; Hudson, James E; Smyth, Susan S; Porrello, Enzo R; Murphy, Andrew J; Nagareddy, Prabhakara R.

Circulation ; 141(13): 1080-1094, 2020 03 31.

Artigo Inglês | MEDLINE | ID: mdl-31941367

16.

Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection.

Richter, Johanna; Monteleone, Mercedes M; Cork, Amanda J; Barnett, Timothy C; Nizet, Victor; Brouwer, Stephan; Schroder, Kate; Walker, Mark J.

Immunol Cell Biol ; 99(10): 1040-1052, 2021 11.

Artigo Inglês | MEDLINE | ID: mdl-34462965

17.

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.

Coll, Rebecca C; Hill, James R; Day, Christopher J; Zamoshnikova, Alina; Boucher, Dave; Massey, Nicholas L; Chitty, Jessica L; Fraser, James A; Jennings, Michael P; Robertson, Avril A B; Schroder, Kate.

Nat Chem Biol ; 15(6): 556-559, 2019 06.

Artigo Inglês | MEDLINE | ID: mdl-31086327

18.

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.

Deora, Vandana; Lee, John D; Albornoz, Eduardo A; McAlary, Luke; Jagaraj, Cyril J; Robertson, Avril A B; Atkin, Julie D; Cooper, Matthew A; Schroder, Kate; Yerbury, Justin J; Gordon, Richard; Woodruff, Trent M.

Glia ; 68(2): 407-421, 2020 02.

Artigo Inglês | MEDLINE | ID: mdl-31596526

19.

Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages.

Kapetanovic, Ronan; Afroz, Syeda Farhana; Ramnath, Divya; Lawrence, Grace Mep; Okada, Takashi; Curson, James Eb; de Bruin, Jost; Fairlie, David P; Schroder, Kate; St John, Justin C; Blumenthal, Antje; Sweet, Matthew J.

Immunol Cell Biol ; 98(7): 528-539, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32686869

20.

Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization.

Murthy, Ambika M V; Sullivan, Matthew J; Nhu, Nguyen Thi Khanh; Lo, Alvin W; Phan, Minh-Duy; Peters, Kate M; Boucher, Dave; Schroder, Kate; Beatson, Scott A; Ulett, Glen C; Schembri, Mark A; Sweet, Matthew J.

FASEB J ; 33(6): 7437-7450, 2019 06.

Artigo Inglês | MEDLINE | ID: mdl-30869997

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