Detalhe da pesquisa
1.
A systems-level study reveals host-targeted repurposable drugs against SARS-CoV-2 infection.
Mol Syst Biol
; 17(8): e10239, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34339582
2.
Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.
Proc Natl Acad Sci U S A
; 116(33): 16593-16602, 2019 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31346086
3.
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.
Handb Exp Pharmacol
; 260: 327-367, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31201557
4.
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.
Bioorg Med Chem Lett
; 26(15): 3581-5, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27381083
5.
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
bioRxiv
; 2024 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38712135
6.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
bioRxiv
; 2024 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-38712213
7.
Validation of a high throughput screening assay to identify small molecules that target the eukaryotic replicative helicase.
SLAS Discov
; 27(4): 229-241, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35058181
8.
Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised.
Elife
; 102021 06 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34180400
9.
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS).
Toxicology
; 448: 152651, 2021 01 30.
Artigo
Inglês
| MEDLINE | ID: mdl-33307106
10.
Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance.
Mol Cancer Res
; 18(7): 1004-1017, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32238439
11.
A High-Throughput Assay for DNA Replication Inhibitors Based upon Multivariate Analysis of Yeast Growth Kinetics.
SLAS Discov
; 24(6): 669-681, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30802412
12.
A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.
Methods Mol Biol
; 1787: 207-222, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29736721
13.
High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands.
Brain Res
; 1151: 227-35, 2007 Jun 02.
Artigo
Inglês
| MEDLINE | ID: mdl-17449017
14.
Adaptation of an in vitro phospholipidosis assay to an automated image analysis system.
Toxicol Mech Methods
; 17(2): 77-86, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-20020975
15.
Biologically Relevant Heterogeneity: Metrics and Practical Insights.
SLAS Discov
; 22(3): 213-237, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28231035
16.
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.
Sci Rep
; 7(1): 17803, 2017 12 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29259176
17.
Comparison of three cell-based drug screening platforms for HSV-1 infection.
Antiviral Res
; 142: 136-140, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28342892
18.
An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.
J Biomol Screen
; 11(7): 743-54, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16973923
19.
Kinase drug discovery by affinity selection/mass spectrometry (ASMS): application to DNA damage checkpoint kinase Chk1.
J Biomol Screen
; 11(7): 755-64, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16956998
20.
A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.
J Biomol Screen
; 21(6): 521-34, 2016 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-26962875