Detalhe da pesquisa
1.
Use of a physiologically based pharmacokinetic-pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.
Br J Clin Pharmacol
; 87(3): 1378-1389, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32822519
2.
Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue.
Eur J Nucl Med Mol Imaging
; 46(2): 396-406, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30121895
3.
Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development.
AAPS J
; 26(1): 1, 2023 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37973662
4.
Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density.
EJNMMI Phys
; 8(1): 37, 2021 Apr 23.
Artigo
Inglês
| MEDLINE | ID: mdl-33891195
5.
Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome.
Ann Clin Transl Neurol
; 7(3): 343-352, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32106360
6.
Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue.
Mol Imaging Biol
; 22(2): 444-452, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31209780
7.
Padsevonil randomized Phase IIa trial in treatment-resistant focal epilepsy: a translational approach.
Brain Commun
; 2(2): fcaa183, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33241213
8.
A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques.
Pharmacol Res Perspect
; 7(1): e00459, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30705758
9.
Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets.
PLoS One
; 12(8): e0182887, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28854243
10.
Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.
Arthritis Res Ther
; 17: 282, 2015 Oct 08.
Artigo
Inglês
| MEDLINE | ID: mdl-26449617
11.
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant.
Biol Psychiatry
; 55(10): 1007-12, 2004 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15121485
12.
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects.
J Clin Pharmacol
; 42(10): 1122-33, 2002 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-12362927
13.
Repeatability of local forearm vasoconstriction to endothelin-1 measured by venous occlusion plethysmography.
Br J Clin Pharmacol
; 54(4): 386-94, 2002 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-12392586