Detalhe da pesquisa
1.
First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants.
Platelets
; 34(1): 2222846, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37394920
2.
An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
Platelets
; 33(7): 979-986, 2022 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35343875
3.
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
Circulation
; 141(18): 1463-1476, 2020 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32237898
4.
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg Med Chem Lett
; 30(4): 126949, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31932224
5.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31445854
6.
First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.
Br J Clin Pharmacol
; 84(5): 876-887, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29346838
7.
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg Med Chem Lett
; 28(6): 987-992, 2018 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29501396
8.
Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals.
J Pharmacol Exp Ther
; 360(3): 466-475, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28035006
9.
Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
J Pharmacol Exp Ther
; 360(3): 476-483, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28035007
10.
Macrocyclic factor XIa inhibitors.
Bioorg Med Chem Lett
; 27(17): 4056-4060, 2017 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28780160
11.
Neutral macrocyclic factor VIIa inhibitors.
Bioorg Med Chem Lett
; 27(12): 2650-2654, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28460818
12.
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Bioorg Med Chem Lett
; 27(16): 3833-3839, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28687203
13.
Apixaban Inhibits Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
J Pharmacol Exp Ther
; 358(3): 405-12, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27384071
14.
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Bioorg Med Chem Lett
; 26(20): 5051-5057, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27612545
15.
Novel phenylalanine derived diamides as Factor XIa inhibitors.
Bioorg Med Chem Lett
; 26(2): 472-478, 2016 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26704266
16.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27073051
17.
Pyridine and pyridinone-based factor XIa inhibitors.
Bioorg Med Chem Lett
; 25(4): 925-30, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25592713
18.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25728130
19.
In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.
J Thromb Thrombolysis
; 40(4): 416-23, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26249722
20.
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Bioorg Med Chem Lett
; 24(5): 1294-8, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24513044