An Application of a Hybrid Intelligent System for Diagnosing Primary Headaches.

(1) Background: Modern medicine generates a great deal of information that stored in medical databases. Simultaneously, extracting useful knowledge and making scientific decisions for diagnosis and treatment of diseases becomes increasingly necessary. Headache disorders are the most prevalent of all the neurological conditions. Headaches have not only medical but also great socioeconomic significance. The aim of this research is to develop an intelligent system for diagnosing primary headache disorders. (2) Methods: This research applied various mathematical, statistical and artificial intelligence techniques, among which the most important are: Calinski-Harabasz index, Analytical Hierarchy Process, and Weighted Fuzzy C-means Clustering Algorithm. These methods, techniques and methodologies are used to create a hybrid intelligent system for diagnosing primary headache disorders. The proposed intelligent diagnostic system is tested with original real-world data set with different metrics. (3) Results: First at all, nine of 20 attributes - features from International Headache Society (IHS) criteria are selected, and then only five most important attributes from IHS criteria are selected. The calculation result based on the Calinski-Harabasz index value (178) for the optimal number of clusters is three, and they present three classes of headaches: (i) migraine, (ii) tension-type headaches (TTHs), and (iii) other primary headaches (OPHs). The proposed hybrid intelligent system shows the following quality metrics: Accuracy 75%; Precision 67% for migraine, 74% for TTHs, 86% for OPHs, and Average Precision 77%; Recall 86% for migraine, 73% for TTHs, 67% for OPHs, Average Recall 75%; F1 score 75% for migraine, 74% for TTHs, 75% for OPHs, and Average F1 score 75%. (4) Conclusions: The hybrid intelligent system presents qualitative and respectable experimental results. The implementation of existing diagnostics systems and the development of new diagnostics systems in medicine is necessary in order to help physicians make quality diagnosis and decide the best treatments for the patients.

Does a probability of breech presentation of more than 50% exist among diseases and medical conditions?

The aim was to study the effect of twin gestations in a uterus with 2 bodies on the probability of breech presentation at delivery. The hypothesis was that the probability of breech presentation was not higher than 50%. A review was undertaken of MEDLINE (1966-2004) and of the article reference list for statistical analysis of presentation at delivery among twins in a normal uterus, singleton gestations in a uterus with 2 bodies, and case studies of twins in a uterus with 2 bodies. There are 10 studies of twin gestations in a normal uterus (Twin A 3036 cases, breech presentation 22.36%; Twin B 2758 cases, breech presentation 36.87%), 2 studies of singleton gestations in a uterus with 2 bodies (297 cases, breech presentation 42.09%), and 57 case report studies of twin gestations in a uterus with 2 bodies (Twin A 56 cases, breech presentation 14.29%; Twin B 54 cases, breech presentation 18.52%). The odds ratio and chi-square test for differences in probabilities show a significantly lower incidence of breech presentation for twins in a uterus with 2 bodies compared with twins in a normal uterus (Twin A, odds ratio = 0.58; chi(2) = 2.08, p > .05, Twin B, odds ratio = 0.39, chi(2) = 7.67, p < .05), and singleton gestations in a uterus with 2 bodies (Twin A, odds ratio = 0.23, chi(2) = 15.51, p < .05; Twin B, odds ratio = 0.31, chi(2) = 10.72, p < .05). Twin gestations in a uterus with 2 bodies decrease the probability of breech presentation.

The fetus cannot exercise like an astronaut: gravity loading is necessary for the physiological development during second half of pregnancy.

On the basis of published Magnetic Resonance Images and the values of the specific fetal and amniotic fluid weights, apparent weight of the fetus from the 18th week of gestation until term was determined. Up to the 21-22nd gestation week the fetus is in conditions similar to neutral floating, while after the 26th gestation week the apparent weight of the fetus is 60-80% of the actual weight. Decreased effect of the buoyant forces that affect the fetus in human species during the last trimester has a number of implications for the colonization of the solar system. During space flight it is impossible to apply the existing countermeasures against microgravity deconditioning of the muscular and cardiovascular systems to the fetus. Absence of gravitational loading during the last trimester of gestation would cause hypotrophy of the spinal extensors and lower extremities muscles, reduction in the amount of myosin heavy chain type I in the extensor muscles of the trunk and legs, hypoplasy and osteopeny of the vertebras and lower extremities long bones, and hypotrophy of the left ventricle of the heart muscle. Because of decreased capacity of postural and locomotor stability, acquisition of the gross developmental milestones such as sitting, standing and walking could be delayed. In the authors' opinion, only artificial gravity (rotating platform) during space flight will allow physiological development of the human fetus. Independency of offspring's of the guinea pig as regards locomotion and nursing increases probability of successful breeding in microgravity compared with rat offspring's, and make this species a candidate for future experiments under conditions of microgravity and hypergravity. Examining the gestation of this species in different gravities requires first the experimental determination of the amount of buoyant force to which the fetus is exposed in physiological conditions.

Breech presentation and tossing a coin: heads or tails.

Through a retrospective review of our own materials and data from peer-reviewed journals, among medical entities a greater probability than 0.5 was not found for breech presentation. Submitting the occurrence of breech presentation to the classical laws of probability means that each fetus in breech presentation has its 'pair' in cephalic presentation. Among medical entities with a probability of less than 0.5 for breech presentation, the group of fetuses in cephalic presentation consist of two subgroups: (1) fetuses which are by chance in cephalic presentation and whose number is identical to the number of fetuses in breech presentation, (2) fetuses which are in cephalic presentation because of the postural development. Likewise, introducing a medical entity with a small number of cases does not allow a conclusion to be drawn about a relationship between that entity and breech presentation.

Probability of breech presentation and its significance.

Existing data related to the probability of breech presentation suggest that the breech presentation is a consequence of mere filling of the intrauterine space, with the same probability of breech and cephalic presentation. As a consequence, group of cephalic presenting fetuses is heterogeneous. Some fetuses randomly assume the cephalic presentation while others assume cephalic presentation 'intentionally' for a reason. Before comparing breech and cephalic presenting fetuses/newborns, bias should be eliminated by subtracting from the cephalic-presenting group the number of fetuses/newborns that is identical with the number of breech-presenting fetuses/newborns with identical characteristics. The subtracted group should be added to the breech-presenting group before comparison with the remaining cephalic-presenting fetuses/newborns. The comparison should be corrected for the gestational age and according to data that are not influenced by delivery. Data suggest that the physiological process that accounts for 92% of cephalic-presenting human fetuses at delivery should be sought from the 25th gestational week onwards.