Detalhe da pesquisa
1.
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
J Biol Chem
; 299(12): 105475, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37981208
2.
GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.
Int J Mol Sci
; 25(4)2024 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38396745
3.
FUS contributes to mTOR-dependent inhibition of translation.
J Biol Chem
; 295(52): 18459-18473, 2020 12 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33082139
4.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Proc Natl Acad Sci U S A
; 111(44): E4769-78, 2014 Nov 04.
Artigo
Inglês
| MEDLINE | ID: mdl-25324524
5.
The function of RNA-binding proteins at the synapse: implications for neurodegeneration.
Cell Mol Life Sci
; 72(19): 3621-35, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26047658
6.
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.
Cell Stress Chaperones
; 29(3): 359-380, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38570009
7.
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.
J Biol Chem
; 287(39): 32298-306, 2012 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22859297
8.
Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.
Acta Neuropathol Commun
; 11(1): 182, 2023 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37974279
9.
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
J Biol Chem
; 286(2): 1204-15, 2011 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-21051541
10.
Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase.
J Biol Chem
; 286(31): 27447-53, 2011 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-21685396
11.
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
J Biol Chem
; 286(18): 16101-8, 2011 May 06.
Artigo
Inglês
| MEDLINE | ID: mdl-21454553
12.
TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.
Biol Chem
; 393(7): 589-94, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22944662
13.
Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease.
Front Mol Neurosci
; 15: 1000183, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36263379
14.
NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis.
eNeuro
; 9(2)2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35165201
15.
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Acta Neuropathol Commun
; 10(1): 20, 2022 02 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35151370
16.
TDP-43 is a developmentally regulated protein essential for early embryonic development.
J Biol Chem
; 285(9): 6826-34, 2010 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-20040602
17.
hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated.
Front Neurosci
; 15: 724307, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34630013
18.
Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways.
Biol Psychiatry
; 90(3): 194-205, 2021 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33867113
19.
Metabolic Networks Influencing Skeletal Muscle Fiber Composition.
Front Cell Dev Biol
; 6: 125, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30324104
20.
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
J Exp Med
; 211(10): 1937-45, 2014 Sep 22.
Artigo
Inglês
| MEDLINE | ID: mdl-25155018