The anatomic basis of connections between the coronary sinus musculature and the left atrium in humans.

BACKGROUND: This study determined the histological features of the atrial myocardium connecting the coronary sinus and the left atrium in humans. METHODS AND RESULTS: Ten necropsied hearts were studied by performing serial longitudinal sections parallel to the long axis of the coronary sinus that extended its full length using a large microtome. In all specimens, the venous wall of the coronary sinus was surrounded by a cuff of striated muscle extending 40+/-8 mm from the ostium. Striated myocardial connections of varying number and morphology left this coronary muscle cuff and connected to the left atrium; they ranged from 1 to 2 fascicles to a widely intermingled continuum (thickness, 2.79+/-2 mm; width, 2.91+/-3.5 mm). These connections originated 8.8+/-5.7 mm from the coronary sinus ostium and inserted 18+/-11 mm distally into the left atrium. The insulating compartment in which the connections traversed between the left atrium and the coronary sinus was mostly formed of adipose tissue. The valve of Vieussens was found in 6 hearts at a mean distance of 3.4+/-3.2 mm from the distal extremity of the coronary sinus muscle cuff. CONCLUSIONS: In the human heart, a consistent but morphologically variable left atrial coronary sinus myocardial connection was found. This emphasizes the need for surgical dissection or catheter ablation in or around the coronary sinus to eliminate these connections.

Prospective randomized comparison of irrigated-tip versus conventional-tip catheters for ablation of common flutter.

BACKGROUND: Radiofrequency (RF) ablation of common flutter requires the creation of a complete ablation line to produce bidirectional conduction block in the cavotricuspid isthmus. An irrigated-tip ablation catheter has been shown to be effective in patients in whom conventional ablation has failed. This randomized study compares the efficacy and safety of this catheter with those of a conventional catheter for de novo flutter ablation. METHODS AND RESULTS: Cavotricuspid ablation was performed with a conventional (n=26) or an irrigated-tip catheter (n=24). RF was applied for 60 minutes with a temperature-controlled mode: 65 degrees C to 70 degrees C up to 70 W with a conventional catheter or 50 degrees C up to 50 W (with a 17-mL/min saline flow rate) with the irrigated-tip catheter. The end point was the achievement of bidirectional isthmus block, and a crossover was performed after 21 unsuccessful applications. Procedural ablation parameters as well as number of applications, x-ray exposure, procedure duration, impedance rise, and clot formation were compared for each group. A coronary angiogram was performed before and after each ablation for the first 30 patients. Complete bidirectional isthmus block was achieved for all patients. Four patients crossed over from conventional to irrigated-tip catheters. The number of applications, procedure duration, and x-ray exposure were significantly higher with the conventional than with the irrigated-tip catheter: 13+/-10 versus 5+/-3 pulses, 53+/-41 versus 27+/-16 minutes, and 18+/-14 versus 9+/-6 minutes, respectively. No significant side effects occurred, and the coronary angiograms of the first 30 patients after ablation were unchanged. CONCLUSIONS: Irrigated-tip catheters were found to be more effective than and as safe as conventional catheters for flutter ablation, facilitating the rapid achievement of bidirectional isthmus block.

Mapping and ablation of left atrial flutters.

BACKGROUND: Typical right atrial isthmus-dependent flutters have been described in detail, but very little is known about left atrial (LA) flutters. METHODS AND RESULTS: We performed conventional and 3D mapping of the LA for 22 patients with atypical flutters. Complete maps in 17 patients demonstrated macroreentrant circuits (n=15) with 1 to 3 loops rotating around the mitral annulus, the pulmonary veins, and a zone of block or a silent area. In 2 patients, a small reentry circuit with a zone of markedly slow conduction was identified. Linear ablation performed across the most accessible part of the circuit cured 16 patients (73%) with a follow-up of 15+/-7 months. CONCLUSIONS: LA reentrant tachycardias are related to individually varying circuits and are amenable to mapping guided radiofrequency ablation.

Electrophysiological end point for catheter ablation of atrial fibrillation initiated from multiple pulmonary venous foci.

BACKGROUND: The end point for catheter ablation of pulmonary vein (PV) foci initiating atrial fibrillation (AF) has not been determined. METHODS AND RESULTS: Ninety patients underwent mapping during spontaneous or induced ectopy and/or AF initiation. Ostial PV ablation was performed by use of angiograms to precisely define targeted sites. Success defined by elimination of AF without drugs was correlated with the procedural end point of the abolition of distal PV potentials. A total of 197 arrhythmogenic PV foci (97%)-single in 31% and multiple in 69%-and 6 atrial foci were identified. A discrete radiofrequency (RF) application eliminated the PV potentials in 9 PV foci, whereas 2 foci from the same PV required RF applications at separate sites in 19 cases. In others, a wider region was targeted with progressive elimination of ectopy. In 49 patients, multiple sessions were necessary owing to recurrent or new ectopy. The clinical success rates were 93%, 73%, and 55% in patients with 1, 2, and > or =3 arrhythmogenic PV foci. Recovery of local PV potential and the inability to abolish it were significantly associated with AF recurrences (90% success rate with versus 55% without PV potential abolition). PV stenosis was noted acutely in 5 of 6 cases, remained unchanged at restudy, and was associated with RF power >45 W. CONCLUSIONS: Multiple PV foci are involved in initiation of AF, and elimination of PV muscle conduction is associated with clinical success.

Electrophysiological breakthroughs from the left atrium to the pulmonary veins.

BACKGROUND: The extent of ostial ablation necessary to electrically disconnect the pulmonary vein (PV) myocardial extensions that initiate atrial fibrillation from the left atrium has not been determined. METHODS AND RESULTS: Seventy patients underwent PV mapping with a circumferential 10-electrode catheter during sinus rhythm or left atrial pacing. After assessment of perimetric distribution and activation sequence of PV potentials, ostial ablation was performed at segments showing earliest activation, with the end point of PV disconnection. A total of 162 PVs (excluding right inferior PVs) were ablated. PV potentials were present at 60% to 88% of their perimeter, but PV muscle activation was always sequential from a segment with earliest activation (breakthrough). Radiofrequency (RF) application at this breakthrough eliminated all PV potentials in 34 PVs, whereas a secondary breakthrough required RF applications at separate segments in 77; in others, >2 segments were ablated. A median of 5, 6, and 4 bipoles from the circular catheter were targeted in the right superior, left superior, and inferior PVs, respectively, to achieve PV disconnection. Early recurrence of arrhythmia was observed in 31 patients as a result of new venous or atrial foci or recovery of previously targeted PVs, most related to a single recovered breakthrough that was reablated with local RF application. CONCLUSIONS: Although PV muscle covers a large extent of the PV perimeter, there are specific breakthroughs from the left atrium that allow ostial PV disconnection by use of partial perimetric ablation.

Efficacy and safety of an irrigated-tip catheter for the ablation of accessory pathways resistant to conventional radiofrequency ablation.

BACKGROUND: Radiofrequency catheter ablation of accessory pathways (APs) is very effective in all but a minority of patients. We examined the usefulness and safety of irrigated-tip catheters in treating patients with APs resistant to conventional catheter ablation. METHODS AND RESULTS: Among 314 APs in 301 consecutive patients, conventional ablation failed to eliminate AP conduction in 18 APs in 18 patients (5.7%), 6 of which were located in the left free wall, 5 in the middle/posterior-septal space, and 7 inside the coronary sinus (CS) or its tributaries. Irrigated-tip catheter ablation was subsequently performed with temperature control mode (target temperature, 50 degrees C), a moderate saline flow rate (17 mL/min), and a power limit of 50 W (outside CS) or 20 to 30 W (inside CS) at previously resistant sites. Seventeen of the 18 resistant APs (94%) were successfully ablated with a median of 3 applications using irrigated-tip catheters. A significant increase in power delivery was achieved (20.3+/-11.5 versus 36.5+/-8.2 W; P:<0.01) with irrigated-tip catheters, irrespective of the AP location, particularly inside the CS or its tributaries. No serious complications occurred. CONCLUSIONS: Irrigated-tip catheter ablation is safe and effective in eliminating AP conduction resistant to conventional catheters, irrespective of the location.

Tracking dynamic conduction recovery across the cavotricuspid isthmus.

OBJECTIVES: We sought to assess the dynamic temporal course of conduction recovery during and after radiofrequency (RF) catheter ablation of the cavotricuspid isthmus. BACKGROUND: Although cavotricuspid isthmus block is accepted as the best end point of ablation for typical flutter, conduction recovery is thought to underlie many eventual recurrences. Its time course and frequency have not been determined. METHODS: In a prospective group of 30 patients (26 men and 4 women, age 64 +/- 12 years) undergoing ablation of typical flutter in the cavotricuspid isthmus, the morphology of the P wave during pacing from the low lateral right atrium after achievement of complete isthmus block was identified as a reference. Regression of this morphologic P wave change was confirmed to be associated with intracardiac evidence of the recovery of cavotricuspid isthmus conduction and was observed throughout the procedure both during ablation in sinus rhythm (n = 15, group B) and just after flutter termination (n = 15, group A). RESULTS: Stable complete isthmus block was achieved in all patients; 29 had a terminal positivity of the paced P wave. Flutter termination resulted in stable block and terminal P wave positivity in three patients, transient terminal P wave positivity and transient block despite continuing RF at the same site in five patients and no block in the remaining seven patients. Conduction recovery identified by recovery of P wave changes was nearly as common (48%) during ablation in sinus rhythm. Multiple recoveries were noted in some patients, and 72% of all recoveries occurred within 1 min. Conduction recovery was only rarely associated with coagulum, impedance elevation or pops. CONCLUSIONS: Conduction recovery in the cavotricuspid isthmus is common during and after ablation and can be accurately, dynamically and continuously observed by monitoring the recovery of the low lateral right atrial paced P wave change.

Partial cavotricuspid isthmus block before ablation in patients with typical atrial flutter.

OBJECTIVES: The purpose of this study was to prospectively evaluate preexisting partial isthmus block in the context of an electrophysiologically directed linear ablation strategy for typical atrial flutter (AF). BACKGROUND: Double potentials (DPs) separated by an isoelectric interval have been recognized as markers of local block. However, the presence and significance of DPs in the cavotricuspid isthmus during AF before ablation have not been evaluated. METHODS: Thirty consecutive patients with AF (counterclockwise: 24, clockwise: 6) were studied during AF. Sequential withdrawal mapping was performed in the cavotricuspid isthmus from the tricuspid valve (TV) to the inferior vena cava (IVC) edge with electrograms coinciding with the center of the surface electrocardiographic plateau during counterclockwise AF or with the initial downslope of the positive flutter wave during clockwise AF. Atrial electrograms along this line were categorized as double, single or fractionated potentials (SPs or FPs). After demarcation of the zone of contiguous DPs, radiofrequency (RF) catheter ablation was performed during AF only at sites with SPs or FPs (other than DPs) on the mapped line. If isthmus conduction still persisted after AF termination, additional RF applications were delivered using the same electrophysiologic strategy of avoiding DPs with an isoelectric interval during low lateral right atrial pacing for filling in the gap of residual conduction. RESULTS: Before ablation, no DPs were recorded in the isthmus in 19 patients (63%); DPs were recorded only at the IVC edge in five patients, and only at the TV edge in one patient. A contiguous line of DPs extending through more than half the isthmus to the IVC edge was documented in five patients (17%: group DP). In group DP, AF was terminated with 1.4+/-0.5 applications (vs. 5.8+/-3.5 in the remaining patients: p < 0.01). Complete isthmus block was achieved with a total of 3.4+/-0.5 applications (vs. 12+/-6 in the remaining patients: p < 0.01). CONCLUSIONS: Seventeen percent of patients undergoing ablation of AF have preexisting partial isthmus block indicated by a large contiguous zone of DPs separated by an isoelectric interval. Electrophysiologically directed linear ablation avoiding confluent DPs can prevent unnecessary applications for effective cure of AF.

Morphological characteristics of P waves during selective pulmonary vein pacing.

OBJECTIVES: We sought to assess the value of 12-lead electrocardiogram (ECG) P-wave morphology to recognize the paced pulmonary vein (PV). BACKGROUND: Prediction of arrhythmogenic PVs producing ectopy or initiating atrial fibrillation (AF) using 12-lead ECG may facilitate curative ablation. METHODS: In 30 patients P-wave configurations were studied during sinus rhythm and during pacing at six sites from the four PVs: top and bottom of each superior PV and both inferior PVs. The P-wave amplitude, duration and morphology were assessed, and predictive accuracies were calculated for the most significant parameters. An algorithm predicting the paced PV was developed and prospectively evaluated in a different population of 20 patients. RESULTS; Three criteria were used to distinguish right from left PV: 1) a positive P-wave in lead aVL and the amplitude of P-wave in lead I > or =50 microV indicated right PV origin (specificity 100% and 97%, respectively); 2) a notched P-wave in lead II was a predictor of left PV origin (specificity 95%); and 3) the amplitude ratio of lead III/II and the duration of positivity in lead V(1) were also helpful in distinguishing left versus right PV origin. In addition, superior PVs could be distinguished from inferior according to the amplitude in lead II (> or =100 microV). In prospective evaluation, an algorithm based on the above four criteria identified 93% of left versus right PV and totally 79% of the specific PVs paced. CONCLUSIONS: Pacing from the different PVs produced a P-wave with distinctive characteristics that could be used as criteria in an algorithm to identify the PV of origin with an accuracy of 79%.

Negative lead I P waves during anteroseptal accessory pathway orthodromic reciprocating tachycardia.

Although a negative retrograde P wave in lead I during orthodromic reciprocating tachycardia is thought to indicate a left free wall accessory pathway, we describe similar negative P waves in lead I during orthodromic reciprocating tachycardia through anteroseptally situated accessory pathways.

Comparison of chronic biventricular pacing between epicardial and endocardial left ventricular stimulation using Doppler tissue imaging in patients with heart failure.

In patients with a wide QRS, drug-resistant heart failure, and a coronary sinus that is unsuitable for transvenous biventricular pacing (BVP), a transseptal approach from the right to left atrium can allow endocardial left ventricular (LV) pacing (with permanent anticoagulant therapy) instead of epicardial pacing via the coronary sinus branches. We sought to compare the effects of endocardial pacing with those of epicardial LV pacing on regional LV electromechanical delay (EMD) and contractility. Twenty-three patients (68 +/- 8 years) with severe heart failure and QRS > or =130 ms received a pacemaker for BVP. Fifteen patients underwent epicardial LV pacing, and 8 underwent endocardial LV pacing because of an unsuitable coronary sinus. All LV leads were placed at the anterolateral LV wall. Six months after implant, echocardiography and Doppler tissue imaging were performed. LV wall velocities and regional EMDs (time interval between the onset of the QRS and local ventricular systolic motion) were calculated for the 4 LV walls and compared for each patient between right ventricular (RV) and BVP. The amplitude of regional LV contractility was also assessed. Epicardial BVP reduced the septal wall EMD by 11% versus RV pacing (p = 0.05) and the lateral wall EMD by 41% versus RV pacing (p <0.01). With endocardial BVP, the septal and lateral EMDs were 21.3% and 54%, respectively (p <0.01, compared with epicardial BVP). The mitral time-velocity integral increased by 40% with endocardial BVP versus 2% with epicardial BVP (p <0.01). The amplitude of the lateral LV wall systolic motion increased by 14% with epicardial BVP versus 31% with endocardial BVP (p = 0.01). This resulted in a LV shortening fraction increase of 25% in patients with endocardial BVP (p = 0.05). However, all patients were clinically improved at the end of follow-up. Thus, in heart failure patients with BVP, endocardial BVP provides more homogenous intraventricular resynchronization than epicardial BVP and is associated with better LV filling and systolic performance.

Efficacy and safety of septal and left-atrial linear ablation for atrial fibrillation.

Atrial fibrillation (AF), the most common of all sustained cardiac arrhythmias, is frequently resistant to antiarrhythmic drugs, and physicians have seen limited success with catheter ablation limited to the right atrium. As a result, the safety and efficacy of systematic biatrial linear ablation for drug resistant AF was investigated. Forty-four patients (54 +/- 7 years) underwent catheter ablation of daily drug-resistant AF. Two right-atrial lines (1 septal and 1 cavotricuspid) and 3-4 left-atrial lines were transseptally performed: 2 joining each superior pulmonary vein to the posterior mitral annulus and 1 interconnecting them. An additional left-atrial septal line from the right superior pulmonary vein (RSPV) to the foramen ovalis was performed in 23 patients. Radiofrequency was delivered with a conventional thermocouple-equipped ablation catheter or with an irrigated tip ablation catheter for resistant cases and for sparing the endocardium. Of the 44 patients, 25 (57%) were successfully treated without antiarrhythmic drugs. Twelve patients (27%) improved (<6 hours of AF per trimester under a previously ineffective drug) and 7 (16%) were considered treatment failures. Multiple sessions were required to ablate new left-atrial macro-reentry and initiating foci (2.7 +/- 1.3 procedures per patient). Five patients had a pericardial effusion and 1 each a pulmonary embolism, an inferior myocardial infarction, and a reversible cerebral ischemic event. One patient had thrombosis of the 2 left pulmonary veins. Despite a relatively high success rate, this procedure is too long, and the safely and efficacy need to be improved and applied to a broader range of patients.

Clinical significance of multiple sensor options: rate response optimization, sensor blending, and trending.

The gold standard for rate modulation is the sinus node. To improve the rate modulation provided by artificial sensors, new sensors have to be developed or 2 different sensor systems can be combined within a single device. Association combination of a sensor with a rapid-response fast-rate increase sensor (activity) and a progressive, more specific sensor (QT ventilation) is generally used. Sensor combinations require adequate sensor blending for signal production and prioritization during rate modulation. However, in the new devices, some other aspects of rate modulation could be taken into consideration, particularly circadian rate variations to obtain lower rates at nighttime than during daytime, and automatic adaptation of the slope of rate increase during exercise, according to the patient's fitness, heart function, age, etc. Despite the need for automaticity, manual programming could continue to be useful to adapt rate modulation with data from sensor trending memories.

Mapping-guided ablation of pulmonary veins to cure atrial fibrillation.

Catheter ablation of triggers inducing paroxysms of atrial fibrillation (AF) is an emerging therapy for this common arrhythmia. In a series of 225 consecutive patients with AF resistant to multiple drugs, 96% presented with triggering foci originating from 1 or multiple pulmonary veins (PV), independently of whether or not the patient had ectopy or structural heart disease. The present article describes the mapping and ablation techniques applicable to individual patients: (1) criteria to define an arrhythmogenic PV; (2) use of provocative maneuvers; and (3) the role of circumferential mapping catheters to provide extent, distribution, and activation of PV muscle as well as monitoring distal PV potentials (PVP) during ablation. Radiofrequency ablation can be performed by targeting the PVP during sinus rhythm (right PV) or left atrial pacing (left PV) with the procedural endpoint of PVP elimination, which is more effective in predicting a successful outcome than suppression of acute ectopy. Complete elimination of AF is presently obtained in 70% of patients, allowing interruption of arrhythmias and in use anticoagulants. It is anticipated that continued technologic improvements will improve and facilitate this technique of curative treatment of AF.

Percutaneous transluminal angioplasty of the carotid artery.

Percutaneous transluminal angioplasty (PTA) is being extensively applied to treat arteriosclerotic lesions. However, this application has not been widely accepted for the treatment of carotid artery stenosis. Successful attempts to relieve cerebral ischemia from extracranial carotid arterial stenosis by PTA are reported. Twenty-seven patients with arteriosclerotic stenosis, fibromuscular disease, and Takayasu carotid arterial stenosis were treated by PTA. All anatomic carotid stenotic lesions were corrected without any neurologic complication. Follow-ups ranged from 3 months to 4 years without recurrent symptoms in any patient. These results may suggest that some patients with cerebral ischemia secondary to extracranial carotid artery stenosis may be treated safely and effectively by PTA.

Atrial fibrillation: role of arrhythmogenic foci.

UNLABELLED: Atrial fibrillation, the most common of all sustained cardiac arrhythmias can be cured by Surgical atriotomies or linear RF catheter ablation. We have investigated the role of focal RF ablation in paroxysmal atrial fibrillation. METHODS: sixteen patients with focal atrial fibrillation (extrasystoles, atrial tachycardia and atrial fibrillation due to the same focus firing irregularly at different rates) and 45 with common AF initiated by extrasystolic foci were included. The ablation site was determined on the basis of earliest bipolar activity relative to a stable atrial electrogram reference or to the P wave onset during atrial fibrillation initiation. RESULTS: All the patients with focal atrial fibrillation were treated with a mean of 5 +/- 4 RF applications delivered on a right atrial site (n = 4) or on a pulmonary venous site (n = 13), (one patient had 2 foci). Sixty nine foci (located in the pulmonary veins in 94%) were identified in the 45 patients with common atrial fibrillation initiated by extrasystoles. They were ablated with a mean of 4.5 +/- 2 RF applications. Using a mean follow up of 8 +/- 6 months, 28/45 (62%) were cured without antiarrhythmic drugs. CONCLUSION: Pulmonary veins play an important role in paroxysmal atrial fibrillation. They are the most frequent source of focal atrial fibrillation and of initiating foci amenable to RF ablation.

Clinically isolated left coronary ostial stenosis: a manifestation of cardiovascular syphilis--case history.

The authors report a case of clinically isolated left coronary ostial stenosis in a thirty-seven-year-old man as a manifestation of cardiovascular syphilis. Notably he was free of the usual risk factors for coronary artery disease, and the rest of the coronary tree was angiographically normal.

An analysis of initial results of percutaneous transluminal coronary angioplasty for totally occluded coronary arteries.

A retrospective analysis of 680 Percutaneous Transluminal Coronary Angioplasties (PTCA) performed from April 1986 to October 1990 revealed that 81 patients had PTCA performed on 86 totally occluded coronary arteries (1.06 lesions/patient). Four of the 86 were acute occlusions. Angiographic success in the group as a whole was achieved in 57 (66%). Multivariate analysis identified only the target vessel as a statistically significant factor predictive of angiographic success from among a host of clinical and angiographic morphologic variables. Left anterior descending artery lesions were identified with the highest success. In addition the duration of occlusion was significantly lower for the successfully versus the unsuccessfully dilated chronic occlusions.

Radiofrequency catheter ablation for AV nodal reentrant tachycardias (AVNRT).

Radiofrequency (RF) catheter ablation is the curative treatment of choice for atrioventricular (AV) nodal reentrant tachycardia (AVNRT). Analogous to the development of surgical techniques, catheter ablation has evolved from AV nodal ablation to selective "fast" and "slow" pathway ablation. "Slow" ablation is now the method of choice because of the lower incidence of associated AV block. Though slow pathway ablation can be achieved with equal success using either the anatomic or the electrogram-guided approach, fewer applications of RF energy are required for the potential-guided technique.

[Endocavitary ablation of nodal reentrant tachycardia]. / Ablation endocavitaire des tachycardies par réentrée nodale.

Atrioventricular nodal reentrant tachycardias which, for a long time, could only be treated medically, may now benefit from catheter ablation. The rapid retrograde pathway was an effective initial target but carried a risk of complete atrioventricular block of about 10%. Nowadays, most operators deliver the radiofrequency energy (endocavitary cautery) to the slow nodal pathway. Different techniques of guidance (anatomical, electrophysiological, rapid potential, slow potential) are associated with high success rates: 90 to 100%. However, experimental studies suggest that the slow potentials arise from transitional cells within the tachycardia circuit (the anatomical substrate of the slow pathway). There is still a risk of complete atrioventricular block (1 to 5%) which should be clearly explained to patients referred for ablation of this constantly benign arrhythmia.