Detalhe da pesquisa
1.
CAR directs T cell adaptation to bile acids in the small intestine.
Nature
; 593(7857): 147-151, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33828301
2.
Quantitative structural assessment of graded receptor agonism.
Proc Natl Acad Sci U S A
; 116(44): 22179-22188, 2019 10 29.
Artigo
Inglês
| MEDLINE | ID: mdl-31611383
3.
Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 1): 155-64, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24419388
4.
PPARγ Modulators in Lung Cancer: Molecular Mechanisms, Clinical Prospects, and Challenges.
Biomolecules
; 14(2)2024 Feb 04.
Artigo
Inglês
| MEDLINE | ID: mdl-38397426
5.
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ.
bioRxiv
; 2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38798544
6.
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states.
bioRxiv
; 2024 Apr 24.
Artigo
Inglês
| MEDLINE | ID: mdl-38712087
7.
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein.
Signal Transduct Target Ther
; 9(1): 144, 2024 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-38853183
8.
Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 69(Pt 10): 1097-9, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24100556
9.
Molecular basis of ligand-dependent Nurr1-RXRα activation.
Elife
; 122023 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37102494
10.
Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders.
J Med Chem
; 66(21): 14815-14823, 2023 11 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37888788
11.
Structural mechanism underlying ligand binding and activation of PPARγ.
Structure
; 29(9): 940-950.e4, 2021 09 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33713599
12.
Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBß.
Sci Adv
; 7(5)2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33571111
13.
A molecular switch regulating transcriptional repression and activation of PPARγ.
Nat Commun
; 11(1): 956, 2020 02 19.
Artigo
Inglês
| MEDLINE | ID: mdl-32075969
14.
Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone.
J Med Chem
; 62(4): 2008-2023, 2019 02 28.
Artigo
Inglês
| MEDLINE | ID: mdl-30676741
15.
Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1.
Structure
; 27(1): 66-77.e5, 2019 01 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30416039
16.
Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.
Structure
; 26(11): 1431-1439.e6, 2018 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30146169
17.
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
Elife
; 72018 12 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30575522
18.
REV-ERBα Regulates TH17 Cell Development and Autoimmunity.
Cell Rep
; 25(13): 3733-3749.e8, 2018 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-30590045
19.
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.
Nat Commun
; 9(1): 4687, 2018 11 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30409975
20.
Defining a conformational ensemble that directs activation of PPARγ.
Nat Commun
; 9(1): 1794, 2018 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29728618