Detalhe da pesquisa
1.
Oxidative Dearomatization of Pyridines.
J Am Chem Soc
; 146(4): 2358-2363, 2024 Jan 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38230893
2.
Reductant-Free Cross-Electrophile Synthesis of Di(hetero)arylmethanes by Palladium-Catalyzed Desulfinative C-C Coupling.
Angew Chem Int Ed Engl
; 61(19): e202116775, 2022 05 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35229419
3.
Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Bioorg Med Chem
; 41: 116205, 2021 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34000509
4.
Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions.
Angew Chem Int Ed Engl
; 60(41): 22461-22468, 2021 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34342107
5.
Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions.
J Am Chem Soc
; 140(46): 15916-15923, 2018 11 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30412397
6.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28289077
7.
Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite.
Angew Chem Int Ed Engl
; 54(46): 13571-5, 2015 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-26383866
8.
Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization.
Org Lett
; 26(14): 2702-2707, 2024 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37094230
9.
Copper-Catalyzed Synthesis of Masked (Hetero)Aryl Sulfinates.
Org Lett
; 26(14): 2817-2820, 2024 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38189248
10.
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J Med Chem
; 63(22): 13546-13560, 2020 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32910646
11.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
J Med Chem
; 63(19): 10879-10896, 2020 10 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32809824
12.
Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
ACS Med Chem Lett
; 9(5): 440-445, 2018 May 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29795756
13.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29456800
14.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
Inglês
| MEDLINE | ID: mdl-29466005
15.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28853885
16.
Reaction of Alkyl Halides with Rongalite: One-Pot and Telescoped Syntheses of Aliphatic Sulfonamides, Sulfonyl Fluorides, and Unsymmetrical Sulfones.
Org Lett
; 18(22): 5848-5851, 2016 11 18.
Artigo
Inglês
| MEDLINE | ID: mdl-27788009
17.
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J Med Chem
; 59(17): 8068-81, 2016 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27490827