Detalhe da pesquisa
1.
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus.
EMBO J
; 43(3): 462-480, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38216735
2.
Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.
Proc Natl Acad Sci U S A
; 118(10)2021 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33649228
3.
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.
Chemistry
; 29(67): e202302426, 2023 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37773020
4.
Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs.
FASEB J
; 36(7): e22380, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35635723
5.
Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling.
Proc Natl Acad Sci U S A
; 117(7): 3568-3574, 2020 02 18.
Artigo
Inglês
| MEDLINE | ID: mdl-32019887
6.
InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.
Proc Natl Acad Sci U S A
; 117(32): 19245-19253, 2020 08 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32727897
7.
New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1.
FASEB J
; 35(2): e21275, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33475202
8.
Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
PLoS Genet
; 14(3): e1007297, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29590114
9.
Flavored e-liquids increase cytoplasmic Ca2+ levels in airway epithelia.
Am J Physiol Lung Cell Mol Physiol
; 318(2): L226-L241, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31693394
10.
KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype.
Proc Natl Acad Sci U S A
; 114(45): 11968-11973, 2017 11 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29078269
11.
Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.
Proc Natl Acad Sci U S A
; 114(52): 13786-13791, 2017 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-29229844
12.
Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues.
Molecules
; 25(19)2020 Oct 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33023101
13.
Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates.
J Biol Chem
; 293(18): 6905-6914, 2018 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29540476
14.
Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
J Biol Chem
; 292(44): 18192-18202, 2017 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28882892
15.
The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.
J Biol Chem
; 292(11): 4544-4555, 2017 03 17.
Artigo
Inglês
| MEDLINE | ID: mdl-28126903
16.
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.
J Cell Physiol
; 233(3): 1897-1912, 2018 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-28542902
17.
The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?
Cytokine
; 110: 298-300, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29456061
18.
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
PLoS Pathog
; 10(2): e1003981, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24586175
19.
Towards pharmacological intervention in inositol pyrophosphate signalling.
Biochem Soc Trans
; 44(1): 191-6, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26862205
20.
Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.
Chemistry
; 22(35): 12406-14, 2016 Aug 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27460418