Acute large-dose exposure to organophosphates in patients with and without diabetes mellitus: analysis of mortality rate and new-onset diabetes mellitus.

BACKGROUND: We investigated the mortality rates of patients with and without diabetes mellitus after acute large-dose exposure to organophosphate insecticides. All patients without diabetes mellitus were traced to examine the long-term risk of new-onset diabetes mellitus. Previous reports indicated that organophosphate exposure might increase the risk of new-onset diabetes mellitus. METHODS: We analyzed the records of 118 patients referred to Chang Gung Memorial Hospital for management of intentional organophosphate poisoning between 2000 and 2011. Patients were stratified by diabetes mellitus status. Demographic, clinical, laboratory and mortality data were analyzed. RESULTS: Most patients were middle aged (53.45 ± 16.20 years) and male (65.3%) and were referred to our hospital after a relatively short amount of time had elapsed since poisoning (median 3.0 hours). 18 (15.2%) of 118 patients died, including 15 (13.8%) of 109 patients without diabetes mellitus and 3 (33.3%) of 9 with diabetes mellitus. There was no significant difference in mortality between these groups (P = 0.117). In a multivariate Cox regression model, hypotension (P = 0.000), respiratory failure (P = 0.042), coma (P = 0.023), and corrected QT interval prolongation (P = 0.002) were significant risk factors for mortality. Conversely, diabetes mellitus status was not a significant variable in this model. At routine outpatient follow up a median of 1.25 months post exposure, random blood glucose measurements gave no evidence of new-onset diabetes in patients without pre-existing diabetes. CONCLUSIONS: Diabetes mellitus status might not increase mortality risk following acute large-dose exposure to organophosphates, and the risk of new-onset diabetes mellitus also might be minimal in the short term. Larger prospective studies with formal testing for diabetes at later times post-exposure are required.

Craniofacial morphologic predictors of oral appliance outcomes in patients with obstructive sleep apnea.

BACKGROUND: Oral appliances (OAs) that advance the mandible can improve the intake of oxygen and reduce the number of apneic episodes in patients who have obstructive sleep apnea. Although OAs are not as effective as continuous positive airway pressure therapy, they are an important therapeutic consideration for patients with obstructive sleep apnea. However, the ability to predict efficacy of OAs is limited. The authors conducted a study to assess the value of relevant clinical and cephalometric variables that can help predict the outcome of OA use in an Asian population. METHODS: Fifty-two Taiwanese patients consecutively treated with OAs were included in the study. Relevant clinical and cephalometric variables were determined at baseline. Treatment success was defined as a reduction of more than 50 percent in the apnea-hypopnea index and the residual apnea-hypopnea index less than 10 per hour with OAs. The predictive value of variables for treatment outcome was evaluated by means of univariate and multivariate analyses. A receiver operating characteristic curve for the multivariate logistic regression model was constructed. RESULTS: A good outcome was found in 29 participants (56 percent). Minimal retroglossal airway, mandibular position and anterior face height were significant predictors of OA treatment success. The area under the receiver operating characteristic curve was 0.862, reflecting good model discrimination. CONCLUSIONS: Some cephalometric variables had a predictive value for the outcome of OA use. OA treatment outcome was favorable in patients with certain craniofacial structures such as narrow minimal retroglossal airway, mandibular retrusion and short anterior face height. CLINICAL IMPLICATIONS: Practitioners should consider OAs for treatment of patients with obstructive sleep apnea who have narrow minimal retroglossal airways, mandibular retrusion and short anterior face heights.