Detalhe da pesquisa
1.
Recombinant strains for the enhanced production of bioengineered rapalogs.
Metab Eng
; 15: 167-73, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23164580
2.
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
Org Biomol Chem
; 6(18): 3315-27, 2008 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-18802638
3.
Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
Chem Commun (Camb)
; (22): 2341-3, 2006 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-16733573
4.
Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents.
Chem Commun (Camb)
; (6): 618-9, 2002 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-12120151
5.
A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase.
J Antibiot (Tokyo)
; 56(6): 543-51, 2003 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-12931864
6.
Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.
Angew Chem Int Ed Engl
; 44(30): 4757-60, 2005 Jul 25.
Artigo
Inglês
| MEDLINE | ID: mdl-15977283
7.
Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
Angew Chem Int Ed Engl
; 43(19): 2551-3, 2004 May 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15127450
8.
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
J Med Chem
; 51(18): 5494-7, 2008 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-18800759
9.
Engineering of the spinosyn PKS: directing starter unit incorporation.
J Nat Prod
; 69(12): 1702-10, 2006 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-17190446
10.
Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
Bioorg Med Chem Lett
; 16(22): 5814-7, 2006 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16962775
11.
Rapamycin biosynthesis: Elucidation of gene product function.
Org Biomol Chem
; 4(19): 3565-8, 2006 Oct 07.
Artigo
Inglês
| MEDLINE | ID: mdl-16990929
12.
Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.
Org Biomol Chem
; 1(23): 4144-7, 2003 Dec 07.
Artigo
Inglês
| MEDLINE | ID: mdl-14685317
13.
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation.
Mol Microbiol
; 52(6): 1745-56, 2004 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15186422
14.
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.
Org Biomol Chem
; 1(16): 2840-7, 2003 Aug 21.
Artigo
Inglês
| MEDLINE | ID: mdl-12968333