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1.
Clin Exp Dermatol ; 44(1): 20-31, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30009576

RESUMO

BACKGROUND: Penile lymphoedema (with and without cellulitis) is a rare, often chronic, clinically heterogeneous entity with an uncertain pathogenesis and an important differential diagnosis. It creates significant physical and psychosexual morbidity, and presents considerable therapeutic challenges. The existing literature is limited. AIM: To describe and share our updated cumulative experience of a cohort of patients with penile lymphoedema. METHODS: This was a retrospective review of the case records of patients with chronic penile lymphoedema seen in two dedicated male genital dermatology clinics between January 2011 and July 2016. RESULTS: In total, 41 cases were identified. Over a third had Crohn disease (CD) (which was occult in one-third of these), and over a third had serological evidence of streptococcal infection. All patients responded to systemic antibiotics and specialized urological surgery circumcision and excision). CONCLUSIONS: Penile lymphoedema should be investigated to exclude underlying pathology especially CD and streptococcal infection. Treatment with antibiotics should be considered early and long term to try to preserve the foreskin: most patients are uncircumcised. Some patients may benefit from a course or courses of oral steroids. The development of gross dysfunction of the prepuce usually dictates circumcision and excision of lymphoedematous tissue once the situation is medically stabilized.


Assuntos
Antibacterianos/uso terapêutico , Circuncisão Masculina , Doença de Crohn/complicações , Linfedema/tratamento farmacológico , Doenças do Pênis/tratamento farmacológico , Infecções Estreptocócicas/complicações , Adolescente , Adulto , Idoso , Doença Crônica , Diagnóstico Diferencial , Humanos , Linfedema/etiologia , Linfedema/cirurgia , Masculino , Pessoa de Meia-Idade , Doenças do Pênis/etiologia , Doenças do Pênis/cirurgia , Pênis/patologia , Estudos Retrospectivos , Infecções Estreptocócicas/tratamento farmacológico , Adulto Jovem
2.
J Eur Acad Dermatol Venereol ; 32(1): 91-95, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28750140

RESUMO

INTRODUCTION: Male genital lichen sclerosus (MGLSc) is an acquired, chronic, inflammatory skin disease that is associated with significant morbidity and squamous cell carcinoma of the penis (PSCC). However, some clinical, diagnostic and management controversies endure, including the relationship with penile intraepithelial neoplasia (PeIN). OBJECTIVES: To clarify clinical presentations, diagnostic approaches, histological findings, response to treatment and the relationship with PeIN. METHODS: Retrospective review of patients with a diagnosis of MGLSc who attended a specialist male genital dermatoses clinic. RESULTS: 301 patients were identified: 260 had isolated MGLSc and 41 both MGLSc and PeIN. Referrals were made from the local Urology and Andrology departments (128), primary care (89), GUM (54), other dermatology departments (28) and other specialties (2). In isolated MGLSc, 94.6% were diagnosed clinically with 93.5% accuracy (based on data from subsequent circumcisions). In combined MGLSc/PeIN, 85.4% were diagnosed following diagnostic biopsy and 14.6% retrospectively after circumcision. In isolated MGLSc, 50% were treated topically, and 50% required surgery. In MGLSc/PeIN, 78% required surgical interventions. In isolated MGLSc, 92.2% achieved resolution of symptoms, 3.5% were awaiting procedures, and 4.8% were receiving ongoing topical therapy. In MGLSc/PeIN, 90.2% achieved clearance, 2.4% were waiting surgery, and 7.3% were treated topically. Only 2.7% reported ongoing symptoms, all in patients treated surgically. None progressed to PSCC. DISCUSSION: MGLSc is generally a disease of the uncircumcised; the majority of cases of MGLSc are accurately diagnosed clinically; suspected PeIN or PSCC requires histological confirmation; circumcision histology can be non-specific; most men are either cured by topical treatment with ultrapotent corticosteroid (53.1%) or by circumcision (46.9%); surgical intervention is required in most cases of concomitant MGLSc and PeIN; the majority of patients with MGLSc alone or with MGLSc and PeIN remit with this approach; effective management appears to negate the risk of malignant transformation to PSCC.


Assuntos
Corticosteroides/uso terapêutico , Balanite Xerótica Obliterante/patologia , Balanite Xerótica Obliterante/terapia , Carcinoma in Situ/patologia , Neoplasias Penianas/patologia , Administração Cutânea , Corticosteroides/administração & dosagem , Balanite Xerótica Obliterante/complicações , Balanite Xerótica Obliterante/diagnóstico , Biópsia , Carcinoma in Situ/complicações , Circuncisão Masculina , Humanos , Masculino , Neoplasias Penianas/complicações , Pênis/patologia , Estudos Retrospectivos
5.
Clin Exp Dermatol ; 41(5): 495-7, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26936088

RESUMO

We describe two patients who received haematopoietic stem cell marrow transplantation, and developed male genital lichen sclerosus (MGLSc), one of whom also had squamous carcinoma in situ (Bowen disease). MGLSc has previously been associated with graft-versus-host disease. Various aetiological factors for LSc have been proposed, including a role for chronic occluded epithelial exposure to urine. A number of factors imply that the risk of malignant transformation in this bone marrow transplant group is likely to be higher than the overall figure of 2-9% cited for MGLSc. It is vital, therefore, that clinicians involved in the care of those with haematological malignancies are adequately prepared to examine the genitals of their patients, and to recognize and refer any suspect penile lesions.


Assuntos
Transplante de Medula Óssea/efeitos adversos , Doença Enxerto-Hospedeiro/patologia , Líquen Escleroso e Atrófico/etiologia , Neoplasias Penianas/etiologia , Adulto , Humanos , Masculino , Adulto Jovem
11.
J Dermatolog Treat ; 33(2): 1047-1062, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32705920

RESUMO

INTRODUCTION: Penile intraepithelial neoplasia (PeIN) is a histological term for precancerous penile lesions. PeIN is important due to the high morbidity and mortality associated with progression to penile squamous cell carcinoma (PSSC). But PeIN is rare, contributing to a limited evidence-base for the relative efficacy of available treatment options. OBJECTIVES & METHODS: To consolidate and expand knowledge about PeIN and its treatment, we describe the clinical and histological characteristics, treatments and outcomes of 345 patients with PeIN, managed by our multidisciplinary team. Our results are compared and contrasted with those in the literature, following comprehensive review. RESULTS: 8.7% of patients had concomitant, invasive PSCC, whilst 91.3% demonstrated PeIN alone. 84% had undifferentiated PeIN, and 10.7% differentiated PeIN (5.2%, not specified). Clinical or histological evidence of HPV alone was present in 58%; features of lichen sclerosus alone in 12%; features of both in 29.4%. Only 14.4% of patients could be treated solely with topical agents or cryotherapy, whereas the remaining 85.6% underwent some form of surgical intervention, circumcision being the mainstay. Just 2.6% progressed to PSCC. CONCLUSIONS: Clinical management of PeIN can be rationally optimized with excellent outcomes. Circumcision is important. Topical treatments alone are disappointing.


Assuntos
Carcinoma in Situ , Líquen Escleroso e Atrófico , Neoplasias Penianas , Neoplasias Cutâneas , Carcinoma in Situ/patologia , Carcinoma in Situ/terapia , Humanos , Líquen Escleroso e Atrófico/patologia , Líquen Escleroso e Atrófico/terapia , Masculino , Neoplasias Penianas/patologia , Neoplasias Penianas/terapia , Pênis/patologia , Neoplasias Cutâneas/patologia
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