Detalhe da pesquisa
1.
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice.
Mol Pharmacol
; 104(2): 73-79, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37316349
2.
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Nat Chem Biol
; 15(3): 250-258, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30643284
3.
Recent progress in covalent warheads for in vivo targeting of endogenous proteins.
Bioorg Med Chem
; 47: 116386, 2021 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34509863
4.
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins.
J Am Chem Soc
; 142(43): 18522-18531, 2020 10 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33047956
5.
Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library.
Chem Pharm Bull (Tokyo)
; 68(11): 1074-1081, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33132374
6.
Design of a binuclear Ni(II)-iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins.
Bioorg Med Chem Lett
; 24(13): 2855-8, 2014 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24835629
7.
Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines.
J Med Chem
; 66(13): 9130-9146, 2023 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37393576
8.
Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease.
Chem Commun (Camb)
; 59(82): 12306-12309, 2023 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37753573
9.
Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide.
Chem Sci
; 13(10): 3027-3034, 2022 Mar 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35432850
10.
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
J Med Chem
; 65(20): 13852-13865, 2022 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-36229406
11.
Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.
ACS Med Chem Lett
; 11(6): 1137-1144, 2020 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32550993
12.
Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Sci Signal
; 11(556)2018 11 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30425165
13.
Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.
EBioMedicine
; 13: 262-273, 2016 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-27745900