Detalhe da pesquisa
1.
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.
Cell
; 183(7): 1986-2002.e26, 2020 12 23.
Artigo
Inglês
| MEDLINE | ID: mdl-33333022
2.
Iterative key-residues interrogation of a phytase with thermostability increasing substitutions identified in directed evolution.
Appl Microbiol Biotechnol
; 100(1): 227-42, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26403922
3.
Extending the substrate scope of a Baeyer-Villiger monooxygenase by multiple-site mutagenesis.
Appl Microbiol Biotechnol
; 98(9): 4009-20, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24247989
4.
Directed evolution of a highly active Yersinia mollaretii phytase.
Appl Microbiol Biotechnol
; 95(2): 405-18, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22159661
5.
Fluorescence Screens for Identifying Central Nervous System-Acting Drug-Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics.
Bio Protoc
; 12(22)2022 Nov 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36532688
6.
Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands.
Elife
; 112022 01 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34982029
7.
Structural analysis of trypanosomal sirtuin: an insight for selective drug design.
Mol Divers
; 14(1): 169-78, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19404761
8.
Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain.
ChemMedChem
; 14(18): 1620-1632, 2019 09 18.
Artigo
Inglês
| MEDLINE | ID: mdl-31334915
9.
Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.
J Gen Physiol
; 151(6): 738-757, 2019 06 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30718376
10.
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum.
Front Cell Neurosci
; 13: 499, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31798415
11.
Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth.
FEMS Microbiol Lett
; 282(2): 266-72, 2008 May.
Artigo
Inglês
| MEDLINE | ID: mdl-18397290
12.
Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands.
Elife
; 112022 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36520038
13.
Protein consensus-based surface engineering (ProCoS): a computer-assisted method for directed protein evolution.
Biotechniques
; 61(6): 305-314, 2016 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27938322
14.
De novo discovery of bioactive cyclic peptides using bacterial display and flow cytometry.
Methods Mol Biol
; 1248: 139-53, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25616331
15.
Multi-site saturation by OmniChange yields a pH- and thermally improved phytase.
J Biotechnol
; 170: 68-72, 2014 Jan 20.
Artigo
Inglês
| MEDLINE | ID: mdl-24315971
16.
P-LinK: A method for generating multicomponent cytochrome P450 fusions with variable linker length.
Biotechniques
; 57(1): 13-20, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25005689
17.
Design of an activity and stability improved carbonyl reductase from Candida parapsilosis.
J Biotechnol
; 165(1): 52-62, 2013 May 10.
Artigo
Inglês
| MEDLINE | ID: mdl-23471075
18.
Reengineered carbonyl reductase for reducing methyl-substituted cyclohexanones.
Protein Eng Des Sel
; 26(4): 291-8, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23355692
19.
OmniChange: the sequence independent method for simultaneous site-saturation of five codons.
PLoS One
; 6(10): e26222, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-22039444
20.
Conformational dynamics of active site loop in Escherichia coli phytase.
Biopolymers
; 93(11): 994-1002, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20574969