RESUMO
Chinese Americans demonstrate greater prevalence of diabetes than non-Hispanic whites and find standard diabetes care disregards their cultural health beliefs. Academic researchers and Chinatown agencies collaborated to culturally adapt and test an efficacious cognitive-behavioral intervention using community-based participatory research. Using a delayed-treatment repeated-measures design, 145 adult Chinese immigrants with Type 2 diabetes completed treatment. Immediate benefits of treatment were evident in the improvement (p < .05) in diabetes self-efficacy, diabetes knowledge, bicultural efficacy, family emotional and instrumental support, diabetes quality of life, and diabetes distress. Prolonged benefits were evident in all changed variables 2 months post-intervention. The CBPR approach enabled the development of a culturally acceptable, efficacious behavioral intervention, and provides a model for working with communities that demonstrate health disparities.
Assuntos
Asiático/psicologia , Pesquisa Participativa Baseada na Comunidade , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Cooperação do Paciente/etnologia , Adaptação Psicológica , Adulto , Idoso , Idoso de 80 Anos ou mais , Atitude Frente a Saúde , Características Culturais , Diabetes Mellitus Tipo 2/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente/psicologia , Avaliação de Programas e Projetos de SaúdeRESUMO
The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can maintain cytotoxicities (IC50 = 15-18 muM) against the HeLa carcinoma cell line evaluated by standard MTT assay. [structure: see text]
Assuntos
Diosgenina/análogos & derivados , Fluoretos , Saponinas/química , Configuração de Carboidratos , Sobrevivência Celular/efeitos dos fármacos , Diosgenina/síntese química , Diosgenina/química , Diosgenina/toxicidade , Glicosilação , Células HeLa , Humanos , Modelos Moleculares , Saponinas/síntese química , Esteroides/síntese química , Trissacarídeos/químicaRESUMO
Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants approximately 10(5) mol(-1) dm(3); the glycosylated arylacetylide complexes exhibit emission at lambda(max) approximately 620 nm in water and are up to approximately 100-times higher in potency than the clinical cisplatin drug in killing cancer cells.
Assuntos
Antineoplásicos/síntese química , Compostos Organoplatínicos/síntese química , Piridinas/síntese química , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Fenômenos Químicos , Físico-Química , Cisplatino/farmacologia , DNA/química , DNA/metabolismo , Ensaios de Seleção de Medicamentos Antitumorais , Eletroforese em Gel de Poliacrilamida , Ensaio de Desvio de Mobilidade Eletroforética , Glicosilação , Humanos , Ligantes , Luminescência , Espectroscopia de Ressonância Magnética , Conformação Molecular , Compostos Organoplatínicos/farmacologia , Fotoquímica , Mapeamento por Restrição , Solubilidade , Espectrofotometria UltravioletaRESUMO
A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.