1.
Chem Sci
; 6(1): 170-173, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25485073
RESUMO
Chiral anion phase-transfer of aryldiazonium cations was utilized to achieve highly enantioselective α-amination of carbonyl compounds. A broad scope of indanone- and benzosuberone-derived substrates was amenable to this strategy. Critical to obtaining high levels of enantioselectivity was the use of BINAM-derived phosphoric acids. The utility of this transformation was demonstrated through facile conversion of diazene products to valuable α-amino acid derivatives.