RESUMO
A rapid, sensitive immuno-assay for mammary tumor virus antigen based on inhibition of passive hemagglutination has been developed. The method permits measurement of this antigen in mouse milk from which the fat has been removed.
Assuntos
Antígenos/análise , Imunoensaio , Vírus do Tumor Mamário do Camundongo/imunologia , Animais , Centrifugação com Gradiente de Concentração , Eritrócitos/imunologia , Haplorrinos , Testes de Inibição da Hemaglutinação , Métodos , Camundongos , Leite/imunologia , OvinosRESUMO
This review describes oncogenic C-type virus and virus-associated antigens as phenotypic expressions of virus activities in malignant cells and cell surface antigens acquired by malignant transformation. The range of host-immune responses to these antigens in experimental systems is discussed in relation to the immunotherapy and immunoprophylaxis of human cancer patients.
Assuntos
Leucemia/prevenção & controle , Retroviridae/imunologia , Anticorpos Antineoplásicos , Anticorpos Antivirais , Antígenos de Neoplasias , Vacina BCG/uso terapêutico , Membrana Celular/imunologia , Reações Cruzadas , Epitopos , Glicoproteínas/imunologia , Imunização Passiva , Leucemia/imunologia , Linfócitos/imunologia , Fenótipo , Vacinação , Proteínas Virais/imunologiaRESUMO
This review article emphasizes the critical role of nonhuman primates (NHPs) in biomedical research. It focuses on the most recent contributions that NHPs have made to the understanding, treatment, and prevention of important infectious diseases (e.g., acquired immunodeficiency syndrome, hepatitis, malaria) and chronic degenerative disorders of the central nervous system (e.g., Parkinson's and Alzheimer's diseases). The close phylogenetic relation of NHPs to humans not only opens avenues for testing the safety and efficacy of new drugs and vaccines but also offers promise for evaluating the potential of new gene-based treatments for human infectious and genetic diseases.