Detalhe da pesquisa
1.
De novo design of modular peptide-binding proteins by superhelical matching.
Nature
; 616(7957): 581-589, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37020023
2.
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Nat Chem Biol
; 19(9): 1127-1137, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37024727
3.
De novo protein design by citizen scientists.
Nature
; 570(7761): 390-394, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31168091
4.
De novo design of potent and selective mimics of IL-2 and IL-15.
Nature
; 565(7738): 186-191, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30626941
5.
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
J Infect Dis
; 228(6): 723-733, 2023 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37279654
6.
Massively parallel de novo protein design for targeted therapeutics.
Nature
; 550(7674): 74-79, 2017 10 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28953867
7.
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.
Proc Natl Acad Sci U S A
; 114(41): 10852-10857, 2017 10 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28973862
8.
Millisecond dynamics of RNA polymerase II translocation at atomic resolution.
Proc Natl Acad Sci U S A
; 111(21): 7665-70, 2014 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24753580
9.
Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes.
PLoS Comput Biol
; 11(7): e1004354, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-26134169
10.
On the molecular basis of the high affinity binding of basic amino acids to LAOBP, a periplasmic binding protein from Salmonella typhimurium.
J Mol Recognit
; 28(2): 108-16, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25604964
11.
Quantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysis.
PLoS Comput Biol
; 10(8): e1003767, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25101697
12.
Application of Markov State Models to simulate long timescale dynamics of biological macromolecules.
Adv Exp Med Biol
; 805: 29-66, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24446356
13.
Hierarchical Nyström methods for constructing Markov state models for conformational dynamics.
J Chem Phys
; 138(17): 174106, 2013 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23656113
14.
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Nat Biotechnol
; 41(4): 532-540, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36316485
15.
Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non-additivity in stability, folding and function.
FEBS J
; 290(18): 4496-4512, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37178351
16.
Monitoring and inhibition of insulin fibrillation by a small organic fluorogen with aggregation-induced emission characteristics.
J Am Chem Soc
; 134(3): 1680-9, 2012 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-22191699
17.
Force field development for cofactors in the photosystem II.
J Comput Chem
; 33(25): 1969-80, 2012 Sep 30.
Artigo
Inglês
| MEDLINE | ID: mdl-22685077
18.
A role for both conformational selection and induced fit in ligand binding by the LAO protein.
PLoS Comput Biol
; 7(5): e1002054, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21637799
19.
An IL-2 Protein Therapeutic for Cancer that Gains Function on the Spot.
Cancer Immunol Res
; 10(5): 544, 2022 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35436336
20.
Conformational dynamics of L-lysine, L-arginine, L-ornithine binding protein reveals ligand-dependent plasticity.
Proteins
; 79(7): 2097-108, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21538545