Association of Tumor Necrosis Factor-α (-G308A) Polymorphism with risk of Upper Gastrointestinal Bleeding from Schistosomiasis in Pernambuco.

BACKGROUND: We evaluated the association between polymorphisms in the tumor necrosis factor alpha (TNF-α) (-G308A) gene and upper gastrointestinal bleeding (UGIB) in schistosomiasis. METHODS: This was a transverse study involving 294 Brazilian patients infected with Schistosoma mansoni. RESULTS: The homozygous A/A genotype in TNF-α (-G308A) showed a risk association (prevalence ratio = 1.90, p = 0.008) with UGIB. There was no statistically significant difference in serum TNF-α levels between the clinical groups. CONCLUSIONS: The polymorphic TNF-α (-G308A) can be a risk factor for UGIB, in addition to being a potentially predictive factor for the severity of UGIB in schistosomiasis.

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment.

INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Association of Tumor Necrosis Factor-α (-G308A) Polymorphism with risk of Upper Gastrointestinal Bleeding from Schistosomiasis in Pernambuco

ABSTRACT Background: We evaluated the association between polymorphisms in the tumor necrosis factor alpha (TNF-α) (-G308A) gene and upper gastrointestinal bleeding (UGIB) in schistosomiasis. Methods: This was a transverse study involving 294 Brazilian patients infected with Schistosoma mansoni. Results: The homozygous A/A genotype in TNF-α (-G308A) showed a risk association (prevalence ratio = 1.90, p = 0.008) with UGIB. There was no statistically significant difference in serum TNF-α levels between the clinical groups. Conclusions: The polymorphic TNF-α (-G308A) can be a risk factor for UGIB, in addition to being a potentially predictive factor for the severity of UGIB in schistosomiasis.

Association Between Polymorphisms of the Mannose-Binding Lectin and Severity of Periportal Fibrosis in Schistosomiasis, in the Northeast of Brazil.

AIMS: Mannose-binding lectin (MBL) is a protein synthesized by the liver and its immune response is associated with the development of liver fibrosis. We hypothesized that the polymorphisms in the Exon 1 region (52, 54, 57) and promoter regions (-550 H/L, -221 X/Y) of the MBL2 gene were associated with the severity of periportal fibrosis (PPF), and that these polymorphisms affect the MBL serum levels. MATERIALS AND METHODS: In this cross-sectional study we genotyped these polymorphisms within the MBL2 gene in 229 Brazilian subjects infected with Schistosoma mansoni, with different patterns of PPF. RESULTS: There was no association between the polymorphisms and haplotypes of the MBL2 gene and the advanced PPF pattern. The MBL levels were higher in individuals with advanced fibrosis. There was risk association among high-expression haplotypes of MBL, and a protection association between the A/O Exon 1 genotype and elevated MBL serum levels. CONCLUSIONS: Our results suggest that polymorphism of Exon 1 and MBL haplotypes could potentially be used to predict the severity of advanced PPF in the Brazilian population.

Influence of a TNF-α Polymorphism on the Severity of Schistosomiasis Periportal Fibrosis in the Northeast of Brazil.

AIMS: The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is an essential component in the host immune response to infection, and it has been reported to be an important mediator in severe periportal fibrosis (PPF). We hypothesized that the (-G308A) polymorphism of the TNF-α gene is associated with the severity of PPF and that these polymorphisms influence TNF-α expression. METHODS: In this cross-sectional study, we genotyped these polymorphisms within the TNF-α gene in 256 Brazilian subjects infected with Schistosoma mansoni, with different patterns of PPF. RESULTS: The genotype (-308) AA was associated with a significant increase in the risk to advanced PPF (OR = 4.60; p = 0.009). In addition, median levels of TNF-α were higher in patients with moderate to advanced PPF, compared with mild fibrosis (20 and 17.3 pg/mL, respectively; p = 0.040). There was no association between average serum levels of TNF-α and (-G308A) TNF-α polymorphism. CONCLUSIONS: Our results suggest the (-308) AA genotype may be a risk factor for severity in advanced PPF, in this Brazilian population, and could potentially be used to predict the severity of advanced PPF in schistosomiasis.

There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment.

INTRODUCTION:: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis. METHODS:: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression. RESULTS:: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment. CONCLUSIONS:: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Abstract INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis.

INTRODUCTION: We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis. METHODS: This cross-sectional study involved 79 patients infected with Schistosoma mansoni with severe or mild/moderate periportal fibrosis. Serum concentrations of mannose-binding lectin were obtained by enzyme-linked immunosorbent assay (ELISA). RESULTS: Higher serum level of mannose-binding lectin was significantly associated with advanced periportal fibrosis. CONCLUSIONS: Mannose-binding lectin may contribute to liver pathology in schistosomiasis and may represent a risk factor for advanced periportal fibrosis in the Brazilian population studied.

Association of SNP (-G1082A) IL-10 with increase in severity of periportal fibrosis in schistosomiasis, in the northeast of Brazil.

Interleukin 10 (IL-10) is an important anti-inflammatory cytokine that modulates severe periportal fibrosis (PPF). We hypothesized that genetic polymorphisms (-G1082A/-C819T/-C592A) of the IL-10 gene and classic factors (age, sex, alcohol, exposure, and specific treatment) are associated with the severity of PPF and that these polymorphisms influence IL-10 expression. In this cross-sectional study, we genotyped these polymorphisms within the IL-10 gene in 203 Brazilian subjects infected with Schistosoma mansoni, with different patterns of PPF. There was an association of protection between the ages of 41 and 60 years and advanced standard PPF. The -1082AA genotype was significantly associated with severity in PPF when compared with the -1082GG genotype. Similarly, when analyzed together, both the -1082GA+AA genotypes were significantly associated. The ACC and GTA haplotypes indicated a protective effect against PPF, while the ATA haplotype was significantly associated with PPF severity when compared with the GCC haplotype. There was no significant difference between average levels of IL-10 between clinical groups, and there was no association between average serum levels of IL-10 and (-G1082A) IL-10 polymorphism. Our results suggest that (-G1082A) IL-10 polymorphism and putative haplotypes are associated with PPF severity in the Brazilian population.

Treatment and education reduce the severity of schistosomiasis periportal fibrosis.

INTRODUCTION: This study evaluates the factors associated with the development of severe periportal fibrosis in patients with Schistosoma mansoni. METHODS: A cross-sectional study was conducted from April to December 2012 involving 178 patients infected with S. mansoni who were treated in the Hospital das Clínicas of Pernambuco, Brazil. Information regarding risk factors was obtained using a questionnaire. Based on the patients' epidemiological history, clinical examination, and upper abdomen ultrasound evaluation, patients were divided into 2 groups: 137 with evidence of severe periportal fibrosis and 41 patients without fibrosis or with mild or moderate periportal fibrosis. Univariate and multivariate analyses were conducted using EpiInfo software version 3.5.5. RESULTS: Illiterate individuals (30.1%) and patients who had more frequent contact with contaminated water in towns in the Zona da Mata of Pernambuco (33.2%) were at greater risk for severe periportal fibrosis. Based on multivariate analysis, it was determined that an education level of up to 11 years of study and specific prior treatment for schistosomiasis were preventive factors for severe periportal fibrosis. CONCLUSIONS: The prevailing sites of the severe forms of periportal fibrosis are still within the Zona da Mata of Pernambuco, although there has been an expansion to urban areas and the state coast. Specific treatment and an increased level of education were identified as protective factors, indicating the need for implementing social, sanitary, and health education interventions aimed at schistosomiasis to combat the risk factors for this major public health problem.

Sistematização da assistência de enfermagem no pós-operatório imediato de cirurgias ortopédicas / Nursing care systematization in the immediate postoperative period after orthopedic surgeries

Objetivos: descrever os principais diagnósticos de enfermagem à luz da teoria das necessidades humanas básicas, proposta por Wanda de Aguiar Horta, segundo a taxonomia da NANDA-I, e propor intervenções e resultados de acordo com a Nursing Interventions Classification (NIC) e a Nursing Outcomes Classification(NOC) para os 5 diagnósticos de enfermagem mais frequentes documentados em um serviço de recuperação pós-anestésica de um hospital de referência em traumatologia. Método: estudo quantitativo, transversal, retrospectivo, descritivo de registro dos principais diagnósticos de enfermagem identificados em prontuários, sendo constituído por 3 etapas: construção do instrumento de coleta de dados; coleta de dados; e processamento e análise dos dados. Resultados: os 5 diagnósticos mais frequentes foram: Risco de infecção(100%); Integridade da pele prejudicada (96,9%); Integridade tissular prejudicada (93,8%); Dor aguda (87,9%);e Déficit no autocuidado para banho/higiene (69,2%). Conclusão: os diagnósticos contribuíram para melhor aplicabilidade do processo de enfermagem de forma individual e holística, para que possam ser implementadas intervenções com resultados mais específicos e direcionados às necessidades prioritárias desses pacientes.

Fatores clínicos e organizacionais relacionados à suspensão de procedimentos cirúrgicos / Clinical and organizational factors related to cancellation of surgical procedures

Objetivo: descrever a frequência e os fatores clínicos e organizacionais relacionados à suspensão de cirurgias. Método: estudo descritivo, retrospectivo, documental, de abordagem quantitativo, que analisou 2.956procedimentos cirúrgicos eletivos em um centro cirúrgico de um hospital escola, por meio de mapas cirúrgicos. Os dados foram submetidos à análise estatística descritiva no programa Epi Info, versão 7.0,apresentados em tabelas e discutidos à luz da literatura. Resultados: foram agendadas 9.648 cirurgias eletivas, sendo 30,6% suspensas. Houve predomínio do sexo feminino e cirurgias de média complexidade. As especialidades que mais suspenderam cirurgias foram: cirurgia geral, cirurgia ortopédica e cirurgia urológica. Os motivos mais frequentes incluíram ausência do paciente, insucesso de cirurgia anterior e substituição de uma cirurgia eletiva por uma cirurgia de emergência. Conclusão: constatou-se que os cancelamentos cirúrgicos podem ser evitados por meio de ações do serviço de busca ativa, bem como atualização de dados dos pacientes e adoção de indicadores para formular políticas institucionais.

Sistematização da Assistência em Enfermagem perioperatória em uma unidade de recuperação pós-anestésica / Systematization of Perioperative Nursing Care in a postanesthetic recovery unit / Sistematización de la Asistencia de Enfermería perioperatoria en una unidad de recuperación post anestésica

Objetivo: descrever os diagnósticos de enfermagem em uma sala de recuperação pós-anestésica (SRPA) e propor os resultados e intervenções para os cinco diagnósticos mais frequentes. Método: estudo descritivo e retrospectivo de registro dos principais diagnósticos de enfermagem identificados e analisados segundo frequências. A amostra foi composta por 63 prontuários referentes ao período de internação no mês janeiro de 2013. Resultados: foram identificados 623 diagnósticos de enfermagem (67 categorias diagnósticas) em 10 domínios da NANDA-II. Os cinco diagnósticos mais frequentes foram: Dor aguda (100%); Risco de desequilíbrio do volume de líquidos (73,4%); Risco de infecção (68,8%); Mobilidade no leito prejudicada (60,7%) e Ansiedade(34,3%). Conclusão: o conhecimento sobre diagnósticos de enfermagem mais frequentes contribui para uma melhor aplicabilidade do processo de enfermagem de forma individual e holística para que possam ser implementadas intervenções com resultados mais específicos e direcionados às necessidades prioritárias desta clientela.(AU)

Objective: to describe the nursing diagnoses in a post-anesthesia care unit (PACU) and to propose the outcomes and interventions for the five most common diagnoses. Method: a descriptive and retrospective registration of the main nursing diagnoses identified and analyzed according to frequency. The sample consisted of 63 records for the period of hospitalization in the month of January 2013. Results: we identified 623 nursing diagnoses (67 diagnostic categories) in 10 areas of NANDA-II. The five most frequent diagnoses were acute pain (100%); liquid volume risk of disequilibrium (73.4%); Risk of infection (68.8%); Mobility Impaired bed (60.7%) and anxiety (34.3%). Conclusion: knowledge about more frequent nursing diagnoses contributes to better application of the nursing process of an individual and holistic manner so that they can be implemented interventions with more specific results and targeted to the priority needs of this clientele.(AU)

Objetivo: describir los diagnósticos de enfermería en un salón de recuperación post anestésico (PACU) y proponen los resultados e intervenciones para los cinco diagnósticos más frecuentes. Método: estudio descriptivo y retrospectivo del registro de los principales diagnósticos de enfermería identificados y analizados según frecuencias. La muestra fue compuesta por 63 prontuarios para el período de hospitalización en el mes de enero de 2013. Resultados: fueron identificados 623 diagnósticos de enfermería (67 categorías diagnósticas) en las 10 áreas de NANDA II. Los cinco diagnósticos más frecuentes fueron: dolor agudo (100%); Riesgo de desequilibrio de volumen de líquido (73,4%); Riesgo de infección (68,8%); Personas con problemas de movilidad en la cama (60,7%) y ansiedad (34,3%). Conclusión: el conocimiento de los diagnósticos de enfermería con frecuencia contribuye a una mejor aplicabilidad del proceso de enfermería de manera individual e integral para que puedan aplicarse con intervenciones dirigidas a las necesidades prioritarias de esta clientela y resultados más específicos.(AU)

There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment

Abstract INTRODUCTION: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis. METHODS: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression. RESULTS: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment. CONCLUSIONS: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.

Vigilância pós-alta em cirurgia geral: assistência de enfermagem sistematizada como ferramenta no controle de infecções / Surveillance after discharge in general surgery: systematic nursing care as a tool in infection control

Objetivos: descrever o comportamento da infecção de sítio cirúrgico em pacientes submetidos à cirurgiageral e propor um protocolo de assistência de enfermagem perioperatória. Método: estudo transversaldescritivo, no qual foram analisados 96 pacientes submetidos à cirurgia geral e atendidos no ambulatório deegressos de um hospital universitário de Recife-PE. Para a coleta de dados foi utilizado um formulário. Oprograma Epi Info 3.5 foi utilizado para análise estatística descritiva. O estudo foi aprovado pelo Comitê deÉtica e Pesquisa, Protocolo n. 101/11. Resultados: houve predominância da faixa etária de 40 a 49 anos, dosexo feminino (62,5%). A prevalência de infecção de sítio cirúrgico foi de 6,3%, com predomínio de infecçõessuperficiais. Não houve informação sobre orientações de enfermagem no período pós-operatório em 89,7% dosprontuários. Conclusão: os dados demonstraram divergências na conduta de enfermagem no períodoperioperatório.

Treatment and education reduce the severity of schistosomiasis periportal fibrosis

Introduction This study evaluates the factors associated with the development of severe periportal fibrosis in patients with Schistosoma mansoni. Methods A cross-sectional study was conducted from April to December 2012 involving 178 patients infected with S. mansoni who were treated in the Hospital das Clínicas of Pernambuco, Brazil. Information regarding risk factors was obtained using a questionnaire. Based on the patients' epidemiological history, clinical examination, and upper abdomen ultrasound evaluation, patients were divided into 2 groups: 137 with evidence of severe periportal fibrosis and 41 patients without fibrosis or with mild or moderate periportal fibrosis. Univariate and multivariate analyses were conducted using EpiInfo software version 3.5.5. Results Illiterate individuals (30.1%) and patients who had more frequent contact with contaminated water in towns in the Zona da Mata of Pernambuco (33.2%) were at greater risk for severe periportal fibrosis. Based on multivariate analysis, it was determined that an education level of up to 11 years of study and specific prior treatment for schistosomiasis were preventive factors for severe periportal fibrosis. Conclusions The prevailing sites of the severe forms of periportal fibrosis are still within the Zona da Mata of Pernambuco, although there has been an expansion to urban areas and the state coast. Specific treatment and an increased level of education were identified as protective factors, indicating the need for implementing social, sanitary, and health education interventions aimed at schistosomiasis to combat the risk factors for this major public health problem. .

Assistência de enfermagem no pós-operatório de cirurgia de varizes: uma proposta de protocolo / Nursing care in the postoperative period of varicose veins surgery: a protocol proposal / Asistencia de enfermería en el postoperatorio de cirugía de varices: una propuesta de protocolo

Objetivo: descrever a assistência de enfermagem no pós-operatório de cirurgia de varizes de membros inferiores e propor um protocolo de assistência. Método: trata-se de um estudo transversal descritivo, tipo série de casos, no qual foram entrevistados 201 pacientes submetidos à cirurgia de varizes de membros inferiores no ambulatório de cirurgia vascular deum hospital universitário de Recife-PE, no período de agosto de 2006 a abril de 2007, no 30º dia de pós-operatório. Foram adotados os seguintes critérios de inclusão: queixa de dor, cansaço, queimação, sensação de peso, inchaço, cãibras em membros inferiores e/ou claudicação no pré-operatório. Para coleta de dados foi utilizado um formulário de entrevista contendo informações sociodemográficas e clínicas. A pesquisa foi aprovada pela Comissão de Ética e Pesquisa do Instituto Materno-Infantil Professor Fernando Figueira, sob o Protocolo n. 827. Os dados foram submetidos à análise estatística descritiva pelo programa Epiinfo 6.04. Resultados: observou-se que os pacientes não receberam no período pós-operatório orientação por parte da enfermagem quanto a banho (62,2%), deambulação (63,2%), curativos após a alta hospitalar (61,2%) e consultas de retorno (60,7%). Em 93% dos casos não houve realização de curativos. Conclusões: os dados demonstram fragilidades nas condutas de enfermagem durante o internamento. Ao término da análise desses dados foi elaborada uma proposta de protocolo de assistência de enfermagem para esse grupo de pacientes visando à melhoria dos cuidados ao paciente cirúrgico operado na instituição.(AU)

Objective: to describe the nursing assistance in the postoperative of lower limb varicose veins surgery and propose an assistance protocol. Method: this is a descriptive transversal study, with a case series design, in which 201 patients who undertook a lower limb varicose veins surgery in the vascular surgery ambulatory of a university hospital in Recife, Pernambuco, Brazil, were interviewed, within the period from August 2006 to April 2007, in the 30th postoperative day. The following inclusion criteria were adopted: pain complaint, fatigue, burning, heavy weight feeling, swelling, lower limb cramps, and/or claudication in the postoperative. For the data collection an interview form with sociodemographic and clinic information was used. The research was approved by the Committee of Ethics and Research of Instituto MaternoInfantil Professor Fernando Figueira, under the Protocol 827. The data underwent a descriptive statistical analysis through the software Epiinfo 6.04. Results: one observes the patients did not receive advice from the nursing staff on bath (62.2%), walk (63.2%), postoperative wound dressings after hospital discharge (61.2%), and follow-up appointments (60.7%). In 93% of the cases patients did not use wound dressings. Conclusions: the data show drawbacks of nursing procedures during hospitalization. At the end of this data analysis, a proposal of nursing assistance protocol was designed for this group of patients, aiming to improve the care of surgical patients operated on at the institution.(AU)

Objetivo: describir la atención de enfermería en el postoperatorio de cirugía de varices de miembros inferiores y proponer un protocolo de atención. Métodos: se trata de un estudio transversal descriptivo de tipo serie de casos en el que se entrevistó a 201 pacientes sometidos a cirugía de varices de los miembros inferiores en el ambulatorio de cirugía vascular de un Hospital Universitario de Recife ­ PE, durante el periodo de agosto de 2006 a abril de 2007 en el trigésimo día de postoperatorio. Se adoptaron los siguientes criterios de inclusión: quejas de dolores, cansancio, ardores, sensación de peso, hinchazón, calambres en miembros inferiores o claudicación en el pre operatorio. Para la recogida de datos se utilizó un impreso de entrevista que contiene informaciones socio-demográficas y clínicas. La investigación fue aprobada por la Comisión de Ética e Investigación del Instituto Materno Infantil Profesor Fernando Siqueira bajo protocolo nº 827. Los datos se sometieron a análisis estadístico descriptivo del programa Epiinfo 6.04. Resultados: se observó que durante el posoperatorio los pacientes no recibieron orientación por parte de la enfermería respecto al baño (62,2%), respecto a sus desplazamientos (63,2%), curativos tras el alta hospitalaria (61,2%) ni sobre consultas de vuelta (60,7%). En el 93% de los casos no se efectuaron curativos. Conclusiones: los datos demuestran fragilidades en las conductas de enfermería durante la internación. Al término del análisis de estos datos, se elaboró una propuesta de protocolo de asistencia de enfermería para este grupo de pacientes en pos de una mejoría de cuidados al paciente quirúrgico operado en la Institución.(AU)

Aspectos epidemiológicos da esquistossomose hepatoesplênica no estado de Pernambuco, Brasil / Epidemiologic aspects of hepatosplenic schistosomiasis in the State of Pernambuco, Brazil

Objetivo: identificar os principais aspectos sociodemográficos e clínicos de portadores da forma hepatoesplênica da esquistossomose em pacientes atendidos em Hospital Universitário de Recife, capital do Estado de Pernambuco, Brasil, no período de setembro de 2008 a março de 2009. Metodologia: estudo descritivo do tipo ‘série de casos’; os casos foram diagnosticados por ultrassonografia de abdome, confirmando fibrose periportal e esplenomegalia. Resultados: comprovou-se faixa etária de maior ocorrência da doença entre 51 e 60 anos, sendo 61 por cento no sexo feminino; sugere-se um aumento do número de casos oriundos de Recife (20,1 por cento) – comparando-se com estudos anteriores – em que cinco desses casos eram nascidos na cidade, além de casos procedentes de Jaboatão dos Guararapes (11,9 por cento); hemorragia digestiva alta (HDA) foi encontrada em 61,6 por cento dos casos e 16 pacientes não foram tratados previamente para esquistossomose. Conclusão: o estudo demonstrou o aparecimento da forma grave da doença no litoral e Região Metropolitana de Recife, bem como a gravidade desses casos pela alta frequência de episódios de HDA, mostrando a necessidade de vigilância contínua dos programas de controle.

Objetive: identify the main clinical and social demographic aspects of the hepatosplenic form of schistosomiasis inpatients attended at the University Hospital in Recife, capital of the State of Pernambuco, Brazil, between september 2008 and march 2009. Methodology: a cross sectional study; the cases were diagnosed by abdominal ultrasound, confirming periportal fibrosis and splenomegaly. Results: the occurrence of the disease proved to be high in the age group from 51 to 60years, presenting 61 per cent of female gender; implies an increase in the number of serious cases arising from Recife (20.1 per cent) in comparison with previous studies, of which 5 been born in the city and more cases coming from Jaboatão dos Guararapes(11.9 per cent); upper digestive bleeding (UDB) was confirmed in 61.6 per cent of the cases, and 16 patients were not treated for schistosomiasis previously. Conclusion: this study demonstrates the appearance of this disease in the coast and in the Metropolitan Area of Recife, as well as the seriousness of these cases due to the high frequency of UDB episodes, indicating the need for efficient control programs and continuous vigilance.