Development of a video analysis protocol and assessment of fall characteristics in equestrian cross-country eventing.

Cross-country eventing is one of the highest-risk sporting activities for serious injury outcomes. This study investigated relationships between fall characteristics and high-risk falls at jumps in cross-country eventing. A video analysis protocol was systematically developed to analyze 87 video recordings of high-risk rider falls; defined as when the rider's head impacted the ground and/or where there was potential horse impact with the rider. Falls were classified according to competition type, jump type, horse-related, and rider-related factors. At least one high-risk fall characteristic was observed in 45 of 87 examined falls. Multivariable best subsets regression identified five independent variables explaining 38.4% of the variance in the number of high-risk falls. Increased likelihood of high-risk falls was associated with continuation of horse direction or speed upon rider ground impact, higher jump approach speed, changes in rider body posture upon landing, rider air jacket usage, and reduced rider fall time. The Eventing Fall Assessment Instrument (EFAI) video analysis protocol (attached as supplementary material) facilitated systematic examination of multiple characteristics associated with high-risk falls and identified likely influential characteristics. Based on EFAI and subsequent data analyses, findings suggest optimized approach speed for correct striding and take-off; jump design to enable run-out; and rider training could help reduce the occurrence of high-risk falls. Air jacket usage and their design characteristics warrant further investigation.

The kinematic differences between skill levels in the squash forehand drive, volley and drop strokes.

Knowledge of the kinematic differences that separate highly skilled and less-skilled squash players could assist the progression of talent development. This study compared trunk, upper-limb and racket kinematics between two groups of nine highly skilled and less-skilled male athletes for forehand drive, volley and drop strokes. A 15-camera motion analysis system recorded three-dimensional trajectories, with five shots analysed per participant per stroke. The highly skilled group had significantly (p < 0.05) larger forearm pronation/supination range-of-motion and wrist extension angles at impact than the less-skilled. The less-skilled group had a significantly more "open" racket face and slower racket velocities at impact than the highly skilled. Rates of shoulder internal rotation, forearm pronation, elbow extension and wrist flexion at impact were greater in the drive stroke than in the other strokes. The position of the racket at impact in the volley was significantly more anterior to the shoulder than in the other strokes, with a smaller trunk rotation angular velocity. Players used less shoulder internal/external rotation, forearm pronation/supination, elbow and wrist flexion/extension ranges-of-motions and angular velocities at impact in the drop stroke than in the other strokes. These findings provide useful insights into the technical differences that separate highly skilled from less-skilled players and provide a kinematic distinction between stroke types.

The kinematic differences between accurate and inaccurate squash forehand drives for athletes of different skill levels.

To maintain the accuracy of squash shots under varying conditions, such as the oncoming ball's velocity and trajectory, players must adjust their technique. Although differences in technique between skilled and less-skilled players have been studied, it is not yet understood how players vary their technique in a functional manner to maintain accuracy under varying conditions. This study compared 3-dimensional joint and racket kinematics and their variability between accurate and inaccurate squash forehand drives of 9 highly skilled and 9 less-skilled male athletes. During inaccurate shots, less-skilled players hit the ball with a more open racket, demonstrating a difference in this task-relevant parameter. No joint kinematic differences were found for accuracy for either group. Coordinated joint rotations at the elbow and wrist both displayed a "zeroing-in" effect, whereby movement variability was reduced from the initiation of propulsive joint rotation to a higher consistency at ball-impact; potentially highlighting the "functionality" of the variability prior to the impact that enabled consistent task-relevant parameters (racket orientation and velocity) under varying conditions. Further, highly skilled players demonstrated greater consistency of task-relevant parameters at impact than less-skilled players. These findings highlight the superior ability of highly skilled players to adjust their technique to achieve consistent task-relevant parameters and a successful shot.

Kinematic Differences in Shoulder Roll and Hip Roll at Different Front Crawl Speeds in National Level Swimmers.

Andersen, JT, Sinclair, PJ, McCabe, CB, and Sanders, RH. Kinematic differences in shoulder roll and hip roll at different front crawl speeds in National Level Swimmers. J Strength Cond Res 34(1): 20-25, 2020-Dry-land strength training is a common component of swimming programs; however, its efficacy is contentious. A common criticism of dry-land strength training for swimming is a lack of specificity. An understanding of movement patterns in swimming can enable dry-land strength training programs to be developed to elicit adaptations that transfer to improvements in swimming performance. This study aimed to quantify the range and velocity of hip roll, shoulder roll, and torso twist (produced by differences in the relative angle between shoulder roll and hip roll) in front crawl at different swimming speeds. Longitudinal torso kinematics was compared between sprint and 400-m pace front crawl using 3D kinematics of 13 elite Scottish front crawl specialists. The range (sprint: 78.1°; 400 m: 61.3°) and velocity of torso twist (sprint: 166.3°·s; 400 m: 96.9°·s) were greater at sprint than 400-m pace. These differences were attributed to reductions in hip roll (sprint: 36.8°; 400 m: 49.9°) without corresponding reductions in shoulder roll (sprint: 97.7°; 400 m: 101.6°) when subjects swam faster. Shoulder roll velocity (sprint: 190.9°·s; 400 m: 139.2°·s) and hip roll velocity (sprint: 75.5°·s; 400 m: 69.1°·s) were greater at sprint than 400-m pace due to a higher stroke frequency at sprint pace (sprint: 0.95 strokes·s; 400 m: 0.70 strokes·s). These findings imply that torques acting to rotate the upper torso and the lower torso are greater at sprint than 400-m pace. Dry-land strength training specificity can be improved by designing exercises that challenge the torso muscles to reproduce the torques required to generate the longitudinal kinematics in front crawl.

The relationship between segmental kinematics and ball spin in Type-2 cricket spin bowling.

The techniques of spin bowling in cricket have been largely formulated from the collective intuitions of past players. A standard model of bowling technique has been generally prescribed for both off-spin and leg-spin bowlers, but there has been no biomechanics research to validate this approach. This study measured 20 Type-2 off-spin and 15 Type-2 leg-spin bowlers using a 3D Cortex motion analysis system. Correlation coefficients between segmental kinematic variables and spin rate in the off-spin and leg-spin bowlers revealed that off-spin bowling was associated with an earlier movement time of the thorax, whereas leg-spin bowling was associated with a greater magnitude and earlier movement time of pelvis rotation, as well as a greater magnitude of pelvis-shoulder separation movement. The maximum velocity of rear hip flexion differentiated between both groups of bowlers. The GLM suggested that for off-spinners, rear hip flexion velocity significantly explained the variance in spin rate (subject to sequential timing constraints), while for leg-spinners, the time of maximum rear hip flexion and maximum arm circumduction velocity significantly explained variance in spin rate. This study supports the notion that off-spinners and leg-spinners have significant differences in their joint kinematics, and should not be coached under a one-size-fits-all technical model.

Physiological and physical characteristics of elite dragon boat paddlers.

The objectives of this study were to profile the physiological and physical characteristics of elite dragon boat paddlers, to identify characteristics that predict race performance and to quantify the metabolic energy contributions to simulated 200-m and 500-m dragon boat racing. Eleven, national level, male, Japanese dragon boat paddlers completed a battery of tests on a paddling ergometer including an incremental maximal aerobic capacity test, a 2-minute maximal accumulated oxygen deficit (MAOD) test, and simulated 200-m and 500-m races. A physiological and physical profile of subjects was compiled. Results showed that 200-m race performance correlated with flexed arm girth and excess postexercise oxygen consumption (EPOC) measured in the 30 minutes after the MAOD test, whereas 500-m race performance correlated with body fat percentage, relaxed and flexed arm girth, MAOD, EPOC, and peak power during the MAOD test. Stepwise multiple regression revealed that flexed arm girth was the most powerful predictor of 200-m and 500-m race performance, followed by EPOC with the combination of these 2 factors able to explain 74% and 68% of the variance in 200-m and 500-m race performance, respectively. Aerobic energy contributions for 200-m (50 seconds) and 500-m (1 minute 50 seconds) races were (mean (95% confidence intervals)) 52.1% (range, 47.4-56.8%) and 67.5% (range, 60.1-77.8%), respectively. In conclusion, coaches should develop training programs targeted at developing upper-body musculature and increasing anaerobic capacity because these factors are the strongest predictors of 200-m and 500-m race performance. Given the substantial aerobic energy contributions even for a 200-m race event, coaches should aim to increase the maximal aerobic capacity of the paddler in preparation for both 200-m and 500-m events.

SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.

SAR studies of the substitution effect on the central phenyl ring of the biphenyl scaffold were carried out using anacetrapib (9a) as the benchmark. The results revealed that the new analogs with substitutions to replace trifluoromethyl (9a) had a significant impact on CETP inhibition in vitro. In fact, analogs with some small groups were as potent or more potent than the CF(3) derivative for CETP inhibition. Five of these new analogs raised HDL-C significantly (>20mg/dL). None of them however was better than anacetrapib in vivo. The synthesis and biological evaluation of these CETP inhibitors are described.

Effect of gender and stroke rate on joint power characteristics of the upper extremity during simulated rowing.

Males typically have greater upper body strength than do females, which is likely to impact on the rowing techniques adopted by each sex. The aim of this study was to quantify energy contributions and compare the joint power production of upper extremity joints between the sexes. Seven males and eight females performed 60 s trials at five different stroke rates. External forces were measured at the handle and stretcher, while kinematics were recorded by motion analysis. Joint moments were derived by inverse dynamic calculations, followed by the calculation of joint powers and gross mechanical energy expenditure. Male rowers expended more total external energy per stroke and made a larger percentage contribution of angular shoulder energy to their total external energy expenditure. As stroke rate increased, the contribution from elbow and angular shoulder energy contributions decreased for both males and females. Female rowers decreased their angular shoulder contribution at a slower rate than did males as stroke rate increased. The overall percentage of work done on the stretcher was higher for male rowers, and this difference further increased at higher stroke rates. The results of this study suggest that specific upper body conditioning may be particularly important for female rowers.

Video analysis of jockey fall characteristics in horse racing.

OBJECTIVES: To identify characteristics of jockey falls associated with high-risk landings using a modified Equestrian Fall Assessment Instrument. DESIGN: Cross-sectional study. METHODS: Video footage of 22 flat and 58 jump racing falls (N = 80) which occurred in Great Britain, Ireland, and New Zealand from 2013 to 2018 was systematically analysed using the modified Equestrian Fall Assessment Instrument. Race, horse, and jockey-level factors, including the nature of ground contact (landings), were characterised identifying factors associated with high-risk landings. High-risk landings refer to cases where the jockey's head impacted the ground or where there was potential horse impact on the jockey. A multivariable logistic regression model was applied identifying independent variables associated with high-risk landings. RESULTS: In 79 % (63/80) of race falls examined, at least one high-risk landing factor was present. Three independent variables explained 40.3 % of variance in high-risk landings. Lower race class (odds ratio 1.5; 95 % confidence interval 0.96, 2.39; p = 0.054), hanging onto the reins upon ground impact (odds ratio 7.5; 95 % confidence interval 1.04, 53.63; p = 0.028), and no jockey tuck-and-roll behaviour following ground impact (odds ratio 4.9; 95 % confidence interval 1.65, 14.44; p = 0.001) were associated with high-risk landings. CONCLUSIONS: Jockeys who ride in lower race classes, who hung onto the reins before landing, and who didn't tuck-and-roll during a fall had increased risk of a high-risk landing. Further examination of relationships between race, jockey experience and fall behaviour characteristics upon injury outcomes, and evaluation of potential protective benefits of fall training are required.

2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: attenuation of hERG binding and improved HDLc-raising efficacy.

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Efforts focused on finding suitable replacements for the central piperidine with the aim of reducing hERG binding: a main liability of our benchmark benzoxazole (1a). Replacement of the piperidine with a cyclohexyl group successfully attenuated hERG binding, but was accompanied by reduced in vivo efficacy. The approach of substituting a piperidine moiety with an oxazolidinone also attenuated hERG binding. Further refinement of this latter scaffold via SAR at the pyridine terminus and methyl branching on the oxazolidinone led to compounds 7e and 7f, which raised HDLc by 33 and 27mg/dl, respectively, in our transgenic mouse PD model and without the hERG liability of previous series.

2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the connectivity of the central aniline lead to a new class of 2-(4-carbonylphenyl)benzoxazoles. Structure-activity studies at the C-7 and terminal pyridine ring allowed for the optimization of potency and HDLc-raising efficacy in this new class of inhibitors. These efforts lead to the discovery of benzoxazole 11v, which raised HDLc by 24 mg/dl in our transgenic mouse PD model.

2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.

We describe structure-activity studies leading to the discovery of 2-arylbenzoxazole 3, the first in a series to raise serum high-density lipoprotein cholesterol levels in transgenic mice. Replacement of the 4-piperidinyloxy moiety with piperazinyl provided a more synthetically tractable lead, which upon optimization resulted in compound 4, an excellent inhibitor of cholesteryl ester transfer protein function with good pharmacokinetic properties and in vivo efficacy.

Racket orientation angle differences between accurate and inaccurate squash shots, as determined by a racket embedded magnetic-inertial measurement unit.

Ascertaining how racket orientation angle differences at ball-impact influence the accuracy of different squash strokes could assist player skill development and possibly reduce the number of unforced errors hit within a match. The purpose of this study was to identify differences in racket orientation angles of accurate and inaccurate forehand and backhand drive, volley and drop shots. A magnetic-inertial measurement unit embedded in a racket output orientation angles of twelve male junior players, with five accurate and five inaccurate shots per player per stroke analysed. Paired samples t-tests revealed that inaccurate backhand drop shots exhibited significantly (p < 0.05) less racket roll angle (racket face less open) at impact than accurate shots, indicating this parameter was a determining factor in the accuracy of this stroke. Racket orientation angle differences between accurate and inaccurate shots of the remaining strokes were too small to be used to distinguish shot accuracy. There was significantly greater variability in racket orientation angles during inaccurate forehand drop and backhand drive shots compared to accurate shots. These findings demonstrate how racket orientation angle differences at ball-impact can influence the accuracy of shots and highlights the need for consistent racket orientations to allow for an accurate shot.

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.

Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased HDL and decreased LDL to coronary heart disease (CHD) risk reduction. This relationship is consistent with a clinical outcomes trial of a CETP inhibitor (anacetrapib) combined with standard of care (statin), which led to a 9% additional risk reduction compared to standard of care alone. We discuss here the discovery of MK-8262, a CETP inhibitor with the potential for being the best-in-class molecule. Novel in vitro and in vivo paradigms were integrated to drug discovery to guide optimization informed by a critical understanding of key clinical adverse effect profiles. We present preclinical and clinical evidence of MK-8262 safety and efficacy by means of HDL increase and LDL reduction as biomarkers for reduced CHD risk.

2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.

A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was found to be beneficial for CETP inhibition. Compound 47 was found to be the most potent inhibitor in this series and inhibited CETP with an IC(50) of 28nM.

2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety.

The development of a series of 2-arylbenzoxazole alpha-alkoxyamide and beta-alkoxyamine inhibitors of cholesteryl ester transfer protein (CETP) is described. Highly fluorinated alpha-alkoxyamides proved to be potent inhibitors of CETP in vitro, and the highly fluorinated 2-arylbenzoxazole beta-alkoxyamine 4 showed a desirable combination of in vitro potency (IC(50)=151 nM) and oral bioavailability in the mouse.

Design of a novel class of biphenyl CETP inhibitors.

A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.

Acute effects of high-intensity dumbbell exercise after isokinetic eccentric damage: interaction between altered pain perception and fatigue on static and dynamic muscle performance.

This study aimed to determine whether high-intensity dumbbell exercise involving both concentric and eccentric contractions would provide a temporary alleviation of delayed-onset muscle soreness (DOMS). It also examined the effect of alleviated muscle soreness on dynamic muscle performance using a stretch-shortening cycle (SSC; peak angular acceleration and velocity of the elbow during both lowering and concentric phases) to provide indirect evidence that DOMS contributes to the dynamic performance decrement after eccentric injury. Thirteen untrained adults performed 30 maximal isokinetic eccentric contractions of the elbow flexors to induce eccentric damage. Five sets of arm curls using a dumbbell (equivalent to 70% of isometric maximal voluntary contraction) were then performed until failure on days 1, 2, 3, and 5 of recovery. Muscle soreness significantly decreased after each session of dumbbell exercise (p = 0.001). Isometric strength further decreased immediately after dumbbell exercise, indicating muscle fatigue (p < 0.001). Dynamic performance variables were less affected by fatigue, however, with performance being reduced only for peak lowering velocity (p < 0.001). Other measures of dynamic performance were relatively constant after dumbbell exercise, particularly on days 2 and 3 when soreness was greatest. It was concluded that high-intensity concentric/eccentric dumbbell exercise was able to temporarily alleviate DOMS and that this reduction in soreness served to counter the effect of peripheral muscle fatigue during dynamic activities. Practical applications of this study are that after eccentric damage, alleviation of muscle soreness through an optimal warm-up may be helpful to temporarily recover dynamic muscle performance. Free-weight loading is one suggested technique to temporarily manage DOMS.

Disubstituted pyrimidines as Lck inhibitors.

We have developed a family of 4-benzimidazolyl-N-piperazinethyl-pyrimidin-2-amines that are subnanomolar inhibitors of Lck. A subset of these Lck inhibitors, with heterocyclic substituents at the benzimidazole C5, are also low-nanomolar inhibitors of cellular IL2 release.

A pilot study of the front foot ground reaction forces in elite female fast bowlers.

This pilot study aimed to determine the magnitude of ground reaction forces experienced by female cricket fast bowlers at front foot contact in the delivery stride of the bowling action. The peak vertical force, peak horizontal braking force and vertical loading rate were assessed in 15 elite Australian female fast bowlers. A sequential averaging procedure indicated that a mean of twelve trials (+/-2.8) were required to achieve performance stability across these ground reaction force variables and this demonstrated the importance of analyzing a sufficient number of trials to obtain representative data. The mean peak vertical ground reaction force was 3.49kN (+/-0.81) and the mean peak horizontal braking force was 2.13kN (+/-0.52). Statistical analyses revealed that differences in body mass explained only 2.3% of the variance in peak vertical force and 2.0% of the variance in peak horizontal braking force so normalization using body mass a covariate is not recommended when reporting front foot ground reaction forces in elite female fast bowlers. The mean time to the peak vertical force was 0.033s (+/-0.009) and the vertical loading rate was 121.31kNs(-1) (+/-73.78). Further work is required to determine the best ways to minimise and attenuate front foot ground reaction forces.