A historical review and analysis on MOORA and its fuzzy extensions for different applications.

Multi-criteria decision-making (MCDM) methods have been widely used among researchers to provide a trade-off solution between best and worst, considering conflicting criteria and sets of preferences. An efficient and systematic literature review of these methods is needed to maintain their application in distinctive domains. To this end, this paper presents a comprehensive and systematic literature survey on "multi-objective optimization by ratio analysis" (MOORA) method and its fuzzy extensions developed and discussed in recent years. This review includes articles categorized based on the publication name, publishing year, journal name, type of applications, and type of fuzzy extensions. In addition, this review will enhance the understanding of practitioners and decision-makers on the MOORA method, its development, fuzzy hybridization, different application areas, and future work. The study revealed that the MOORA technique was predominantly used with the TOPSIS approach, followed by the AHP and COPRAS methods. Furthermore, 76.28 % use single and hybridization approaches among all MOORA studies, while 23.72 % use MOORA in a fuzzy environment.

Structural insights into actin isoforms.

Actin isoforms organize into distinct networks that are essential for the normal function of eukaryotic cells. Despite a high level of sequence and structure conservation, subtle differences in their design principles determine the interaction with myosin motors and actin-binding proteins. Therefore, identifying how the structure of actin isoforms relates to function is important for our understanding of normal cytoskeletal physiology. Here, we report the high-resolution structures of filamentous skeletal muscle α-actin (3.37 Å), cardiac muscle α-actin (3.07 Å), ß-actin (2.99 Å), and γ-actin (3.38 Å) in the Mg2+·ADP state with their native post-translational modifications. The structures revealed isoform-specific conformations of the N-terminus that shift closer to the filament surface upon myosin binding, thereby establishing isoform-specific interfaces. Collectively, the structures of single-isotype, post-translationally modified bare skeletal muscle α-actin, cardiac muscle α-actin, ß-actin, and γ-actin reveal general principles, similarities, and differences between isoforms. They complement the repertoire of known actin structures and allow for a comprehensive understanding of in vitro and in vivo functions of actin isoforms.

The protein actin is important for many fundamental processes in biology, from contracting muscle to dividing a cell in two. As actin is involved in such a variety of roles, human cells have slightly different versions of the protein, known as isoforms. For example, alpha-actin is vital for contracting muscle, while beta- and gamma-actin drive cellular processes in non-muscle cells. In order to carry out its various functions, actin interacts with many other proteins inside the cell, such as myosin motors which power muscle contraction. These interactions rely on the precise chain of building blocks, known as amino acids, that make up the actin isoforms; even subtle alterations in this sequence can influence the behavior of the protein. However, it is not clear how differences in the amino acid sequence of the actin isoforms impact actin's interactions with other proteins. Arora et al. addressed this by studying the structure of four human actin isoforms using a technique called cryo-electron microscopy, where the proteins are flash-frozen and bombarded with electrons. These experiments showed where differences between the amino acid chains of each isoform were located in the protein. Arora et al. then compared their structures with previous work showing the structure of actin bound to myosin. This revealed that the tail-end of the protein (known as the N-terminus) differed in shape between the four isoforms, and this variation may influence how actin binds to others proteins in the cell. These results are an important foundation for further work on actin and how it interacts with other proteins. The structures could help researchers design new tools that can be used to target specific isoforms of actin in different types of laboratory experiments.

Shape synthesis of an assistive knee exoskeleton device to support knee joint and rehabilitate gait.

Purpose: The assistive knee exoskeleton device is used for supporting the surrounding ligaments, tendons, and muscles of the injured knee joint. Various knee exoskeletons have been discussed; however, their shape synthesis is not reported. This study aims to present the shape synthesis of the assistive knee device. Moreover, four-bar linkage is used for the knee exoskeleton, in this study. Methods: Clinical biomechanical data are adapted from gait database for one gait cycle. Using the clinical gait data, position and static force analyses are performed to obtain a set of orientations and unknown forces. Simultaneously, CAD models are prepared, and the obtained forces are applied to the CAD models of the four-bar linkage knee exoskeleton. Consequently, the threshold is obtained for each component of the knee exoskeleton and the unwanted material below the threshold is removed. Results: A reduction of 45% in the peak actuating force is observed in comparison with the literature. Besides, a total reduction of 21% in the mass of four-bar knee exoskeleton is observed in contrast to the base models when shape synthesis is performed. Conclusions: An assistive knee exoskeleton is developed using the shape synthesis methodology in which four-bar linkage is used. New shapes of thigh and shank attachments are obtained. The developed knee exoskeleton can be used by persons with the injured knee for supporting the ligaments, tendons, and muscles. Besides, control technology can be implemented to make it useful for persons with monoplegia. Implications for rehabilitation Assistive knee exoskeleton devices proved to be an important tool for providing support to injured knee joints. Typically single axis joints are observed in the lower limb exoskeletons which can be replaced with linkage mechanisms to obtain the desired range of motion. In this study, four-bar linkages are used for the knee exoskeleton in which cranks and rockers are connected to the lateral and medial sides of the knee joint, for connecting shank and thigh attachments. Shape synthesis is performed on the components of four-bar exoskeleton through the evaluated reaction forces. The components are assembled to form an assistive knee exoskeleton which can be used by any person with injured knee joint.

A novel gait-based synthesis procedure for the design of 4-bar exoskeleton with natural trajectories.

BACKGROUND/OBJECTIVE: Human walking involves the coordination of brain, nerves, and muscles. A disturbance in their coordination may result in gait disorder. The gait disorder may be treated through manually assisted gait training or with the aid of assistive devices/robotic devices. These robotic devices involve mechanisms which are synthesized using complex conventional procedures. Therefore, in this study, a new gait-based synthesis procedure is proposed, which simplifies the mechanism synthesis and helps to develop a mechanism which can be used in rehabilitation devices, bipeds, etc. METHODS: This article presents a novel procedure for the synthesis of 4-bar linkage using the natural gait trajectories. As opposed to the conventional synthesis procedures, in this procedure, a global reference frame is considered, which allows the use of hip trajectory while moving. Moreover, this method is divided into two stages, and five precision points are considered on the hip trajectory in each stage. In the first stage, the 4-bar linkage is designed, thereafter, the configurations of the linkage for the remaining precision points are determined in the second stage. The proposed synthesis procedure reduces the complexity involved in the synthesis and helps in the simplification of the problem formulation. A two-stage optimization problem is formulated for minimizing the error between the generated and desired hip trajectories. Two nature-inspired algorithms are used for solving the optimization problem. The obtained best results are presented, and the designed linkage is simulated in MATLAB. RESULTS: The best design of the linkage is obtained using particle swarm optimization. The trajectories generated by the designed linkage using the proposed methodology can accurately track the desired path, which indicates that designed linkage can achieve all the orientations required during walking. The positions of a whole lower limb at all the desired precision points are demonstrated by stick diagram for one gait. CONCLUSION: The proposed methodology has reduced the complexity of synthesis procedures and used optimization techniques to obtain a feasible design of the mechanism. The stick diagram of the designed mechanism obtained using the proposed method indicates that the designed mechanism can walk smoothly. Hence, the designed mechanism can be used in the rehabilitation devices. Furthermore, a conceptual design of an exoskeleton knee is also presented. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: Many hospitals and individuals have used the immobile and portable rehabilitation devices. These devices involve mechanisms, and the design of mechanism plays a vital role in the functioning of these devices; therefore, we have developed a new synthesis procedure for the design of the mechanism. Besides synthesis procedure, a mechanism is developed that can be used in the rehabilitation devices, bipeds, exoskeletons, etc., to benefit the society.

Comparison of the effect of different medicaments on surface reproduction of two commercially available Polyvinyl Siloxane impression materials - An Invitro Study.

OBJECTIVE: To determine the effect of different retraction cord medicaments on surface detail reproduction of polyvinyl siloxane impression materials and compare this effect on any two brands of commercially available polyvinyl siloxane impression materials. MATERIAL AND METHODS: Four stainless steel dies were made according to ADA specification no.19. Three dies were treated with aluminium chloride (5%), ferric sulphate (13.3%) and epinephrine (0.1%) while the fourth one was left untreated to serve as control. Two impression materials (Dentsply and 3M ESPE) were used. RESULTS: All the three medicaments adversely affected the surface detail reproduction of both the brands of the polyvinyl siloxane impression materials. These effects were statistically significant as compared to untreated control. The impressions of 3M ESPE brand have shown better surface detail reproduction as compared to Dentsply impression material. CONCLUSION: Surface detail reproduction of the polyvinyl siloxane impression materials is adversely affected by the retraction cord medicaments. The presence of moisture or any traces of the medicaments should be removed from the tooth surface to provide a dry field for the correct reproduction of the surface detail of these materials. Key words:Polyvinyl Siloxane, retraction cord medicaments, surface detail reproduction.