Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data.

The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely accessed and highly functional data repository housing primary phenotype data for the laboratory mouse accessible via APIs and providing tools to analyze and visualize those data. Data come from investigators around the world and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses rigorously curated per-animal data with detailed protocols. Public ontologies and controlled vocabularies are used for annotation. In addition to phenotype tools, genetic analysis tools enable users to integrate and interpret genome-phenome relations across the database. Strain types and populations include inbred, recombinant inbred, F1 hybrid, transgenic, targeted mutants, chromosome substitution, Collaborative Cross, Diversity Outbred and other mapping populations. Our new analysis tools allow users to apply selected data in an integrated fashion to address problems in trait associations, reproducibility, polygenic syndrome model selection and multi-trait modeling. As we refine these tools and approaches, we will continue to provide users a means to identify consistent, quality studies that have high translational relevance.

Immunological role of hardiness on depression.

The present study holds hardiness as the independent variable and depression as the dependent variable. The immunological role of hardiness was ascertained on depression. Sample constituted of 320 people aging 21 to 65. Subjects were administered hardiness scale and depression scale. Based on the scores obtained on hardiness scale, subjects were categorized specifically into three hardy groups: high, moderate, and low to see their differential effects on depressive feelings. The differences between the means of three hardy groups were found to be significant and the immunological role of hardiness on depression is thoroughly highlighted.