1.
Bioorg Med Chem Lett
; 17(24): 6910-3, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17976987
RESUMO
Several P4 domain derivatives of the general d-phenylglycinamide-based scaffold (2) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent compounds were evaluated for their anticoagulant effects in vitro. A select subset containing various P1 indole constructs was further evaluated for their pharmacokinetic properties after oral administration to rats.