Detalhe da pesquisa
1.
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.
J Neurochem
; 2023 Mar 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36949663
2.
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease.
Cell Mol Life Sci
; 76(12): 2449-2461, 2019 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-30830240
3.
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.
Hum Mol Genet
; 26(6): 1115-1132, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28104789
4.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Proc Natl Acad Sci U S A
; 111(8): 3032-7, 2014 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-24516159
5.
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Hum Mol Genet
; 23(3): 717-29, 2014 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24070868
6.
Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.
Mol Ther
; 23(11): 1759-1771, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26201449
7.
A fully humanized transgenic mouse model of Huntington disease.
Hum Mol Genet
; 22(1): 18-34, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23001568
8.
In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.
Mol Ther
; 22(12): 2093-2106, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25101598
9.
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.
Nucleic Acids Res
; 41(21): 9634-50, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23963702
10.
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Hum Mol Genet
; 21(9): 1954-67, 2012 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22262731
11.
Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease.
Nat Commun
; 14(1): 4348, 2023 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37468457
12.
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.
Cell Death Dis
; 12(11): 954, 2021 10 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34657143
13.
Reduced gluconeogenesis and lactate clearance in Huntington's disease.
Neurobiol Dis
; 40(3): 656-62, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-20727971
14.
Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome.
Biol Psychiatry
; 88(6): 500-511, 2020 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32653109
15.
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
Cell Chem Biol
; 26(9): 1295-1305.e6, 2019 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31353319
16.
Site-specific characterization of endogenous SUMOylation across species and organs.
Nat Commun
; 9(1): 2456, 2018 06 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29942033
17.
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism.
Cell Rep
; 23(7): 2211-2224, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29768217
18.
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.
Acta Neuropathol Commun
; 6(1): 16, 2018 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29510748
19.
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease.
Sci Transl Med
; 10(461)2018 10 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30282695
20.
Palmitoylation of caspase-6 by HIP14 regulates its activation.
Cell Death Differ
; 24(3): 433-444, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27911442