Detalhe da pesquisa
1.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22922757
2.
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Bioorg Med Chem Lett
; 23(3): 682-6, 2013 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23273517
3.
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.
J Nat Prod
; 75(5): 980-5, 2012 May 25.
Artigo
Inglês
| MEDLINE | ID: mdl-22591513
4.
Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.
Mol Pharm
; 8(4): 1292-302, 2011 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21630681
5.
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorg Med Chem Lett
; 20(11): 3387-93, 2010 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20451379
6.
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Bioorg Med Chem Lett
; 19(13): 3686-92, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19464886
7.
A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.
J Am Chem Soc
; 130(15): 5115-23, 2008 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-18357984
8.
Identification of a potent new chemotype for the selective inhibition of PDE4.
Bioorg Med Chem Lett
; 18(4): 1297-303, 2008 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18243697
9.
Synthesis of Substituted 2-phenylhistamines via a Microwave Promoted Suzuki Coupling.
Tetrahedron Lett
; 48(52): 9140-9143, 2007 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19112479
10.
Extending Pummerer reaction chemistry. Synthesis of (+/-)-dibromophakellstatin by oxidative cyclization of an imidazole derivative.
Org Lett
; 7(5): 929-31, 2005 Mar 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15727477
11.
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.
Pharmacol Biochem Behav
; 98(3): 349-55, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21296104
12.
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
J Med Chem
; 53(3): 1048-55, 2010 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-20017496
13.
Extending Pummerer reaction chemistry. Synthesis studies in the phakellin alkaloid area.
J Org Chem
; 72(21): 8076-86, 2007 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-17850163
14.
The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors.
Int J Biol Sci
; 2(4): 179-85, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16810332