Detalhe da pesquisa
1.
Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Nature
; 604(7904): 160-166, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35355011
2.
Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency.
Chem Res Toxicol
; 37(2): 181-198, 2024 02 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38316048
3.
Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.
Toxicol Appl Pharmacol
; 459: 116342, 2023 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36502871
4.
Retrospective analysis of the potential use of virtual control groups in preclinical toxicity assessment using the eTOX database.
Regul Toxicol Pharmacol
; 138: 105309, 2023 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-36481280
5.
Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database.
Regul Toxicol Pharmacol
; 138: 105308, 2023 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-36481279
6.
Prediction of In Vivo Pharmacokinetic Parameters and Time-Exposure Curves in Rats Using Machine Learning from the Chemical Structure.
Mol Pharm
; 19(5): 1488-1504, 2022 05 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35412314
7.
RNA as a small molecule druggable target.
Bioorg Med Chem Lett
; 27(23): 5083-5088, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29097169
8.
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Bioorg Med Chem Lett
; 27(12): 2721-2726, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28501511
9.
Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications.
Bioorg Med Chem Lett
; 25(22): 5384-8, 2015 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26403930
10.
Targeting RNA with small molecules-A safety perspective.
Br J Pharmacol
; 2023 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36631428
11.
The Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals.
J Pharm Sci
; 112(5): 1287-1304, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36402198
12.
Revisiting the Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals.
J Pharm Sci
; 112(12): 3005-3011, 2023 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37805074
13.
Artificial Intelligence in Drug Safety and Metabolism.
Methods Mol Biol
; 2390: 483-501, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-34731484
14.
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.
Stem Cell Reports
; 17(3): 556-568, 2022 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35148844
15.
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Bioorg Med Chem Lett
; 21(21): 6591-5, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21955944
16.
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
J Med Chem
; 64(18): 13524-13539, 2021 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34478292
17.
Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies.
J Med Chem
; 63(12): 6251-6275, 2020 06 25.
Artigo
Inglês
| MEDLINE | ID: mdl-31714773
18.
Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space.
SLAS Discov
; 25(4): 384-396, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31701793
19.
Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles.
ACS Med Chem Lett
; 10(6): 874-879, 2019 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31223441
20.
Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection-Mass Spectrometry.
SLAS Discov
; 24(2): 142-157, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30204533